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URB2 URB2 ribosome biogenesis homolog [ Homo sapiens (human) ]

Gene ID: 9816, updated on 9-Aug-2018

Summary

Official Symbol
URB2provided by HGNC
Official Full Name
URB2 ribosome biogenesis homologprovided by HGNC
Primary source
HGNC:HGNC:28967
See related
Ensembl:ENSG00000135763 Vega:OTTHUMG00000039464
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NPA2; NET10; KIAA0133
Expression
Ubiquitous expression in testis (RPKM 4.6), lymph node (RPKM 2.3) and 25 other tissues See more
Orthologs

Genomic context

See URB2 in Genome Data Viewer
Location:
1q42.13
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (229626216..229660200)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (229761981..229795946)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 19 Neighboring gene TATA-box binding protein associated factor 5 like Neighboring gene KIAA1191 pseudogene Neighboring gene high mobility group box 1 pseudogene 26

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Phenotypes

NHGRI GWAS Catalog

Description
Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines.
NHGRI GWA Catalog
Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0133, MGC138837, MGC138838

Gene Ontology Provided by GOA

Process Evidence Code Pubs
ribosome biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
aggresome IDA
Inferred from Direct Assay
more info
 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
unhealthy ribosome biogenesis protein 2 homolog
Names
URB2 ribosome biogenesis 2 homolog
nucleolar preribosomal-associated protein 1
nucleolar preribosomal-associated protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050743.1 RefSeqGene

    Range
    5012..38996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001314021.1NP_001300950.1  unhealthy ribosome biogenesis protein 2 homolog

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AW611528, BC114559, DC369323
    Consensus CDS
    CCDS31052.1
    UniProtKB/Swiss-Prot
    Q14146
    Conserved Domains (1) summary
    pfam10441
    Location:13221516
    Urb2; Urb2/Npa2 family
  2. NM_014777.3NP_055592.2  unhealthy ribosome biogenesis protein 2 homolog

    See identical proteins and their annotated locations for NP_055592.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AW611528, D50923, DC369323
    Consensus CDS
    CCDS31052.1
    UniProtKB/Swiss-Prot
    Q14146
    Related
    ENSP00000258243.2, OTTHUMP00000037473, ENST00000258243.6, OTTHUMT00000095232
    Conserved Domains (1) summary
    pfam10441
    Location:13221516
    Urb2; Urb2/Npa2 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    229626216..229660200
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005273360.3XP_005273417.1  unhealthy ribosome biogenesis protein 2 homolog isoform X1

    Conserved Domains (1) summary
    pfam10441
    Location:12851478
    Urb2; Urb2/Npa2 family
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