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Urb2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) [ Mus musculus (house mouse) ]

Gene ID: 382038, updated on 5-Mar-2024

Summary

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Official Symbol
Urb2provided by MGI
Official Full Name
URB2 ribosome biogenesis 2 homolog (S. cerevisiae)provided by MGI
Primary source
MGI:MGI:2681124
See related
Ensembl:ENSMUSG00000031976 AllianceGenome:MGI:2681124
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0133
Summary
Predicted to be involved in ribosome biogenesis. Predicted to be located in aggresome and midbody. Predicted to be active in nucleolus. Is expressed in glossopharyngeal ganglion and trigeminal ganglion. Orthologous to human URB2 (URB2 ribosome biogenesis homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 13.3), thymus adult (RPKM 5.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 E2; 8 72.33 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (124748236..124775244)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (124021497..124048505)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family B member 10 Neighboring gene predicted gene, 53469 Neighboring gene STARR-seq mESC enhancer starr_22990 Neighboring gene TATA-box binding protein associated factor 5 like Neighboring gene STARR-seq mESC enhancer starr_22991 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene microRNA 1967 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:126581223-126581424 Neighboring gene predicted gene, 29897 Neighboring gene predicted gene, 30005

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
  2. ALS-linked loss of Cyclin-F function affects HSP90. Siebert A, et al. Life Sci Alliance, 2022 Sep 16. PMID 36114006, Free PMC Article
  3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0133

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in ribosome biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in aggresome ISO
Inferred from Sequence Orthology
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
unhealthy ribosome biogenesis protein 2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029876.2 → NP_001025047.1  unhealthy ribosome biogenesis protein 2 homolog

    See identical proteins and their annotated locations for NP_001025047.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC139575
    Consensus CDS
    CCDS22768.1
    UniProtKB/TrEMBL
    B9EKU4, E9Q7L1
    Conserved Domains (1) summary
    pfam10441
    Location:1321 → 1516
    Urb2; Urb2/Npa2 family

  2. NM_001368414.1 → NP_001355343.1  unhealthy ribosome biogenesis protein 2 homolog

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC139575
    Consensus CDS
    CCDS22768.1
    UniProtKB/TrEMBL
    B9EKU4, E9Q7L1
    Related
    ENSMUSP00000034457.9, ENSMUST00000034457.9
    Conserved Domains (1) summary
    pfam10441
    Location:1321 → 1516
    Urb2; Urb2/Npa2 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    124748236..124775244
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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