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TOMM20 translocase of outer mitochondrial membrane 20 [ Homo sapiens (human) ]

Gene ID: 9804, updated on 7-Dec-2018

Summary

Official Symbol
TOMM20provided by HGNC
Official Full Name
translocase of outer mitochondrial membrane 20provided by HGNC
Primary source
HGNC:HGNC:20947
See related
Ensembl:ENSG00000173726 MIM:601848
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAS20; MOM19; TOM20
Expression
Ubiquitous expression in thyroid (RPKM 101.1), brain (RPKM 96.3) and 25 other tissues See more
Orthologs

Genomic context

See TOMM20 in Genome Data Viewer
Location:
1q42.3
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (235109341..235128941, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (235272656..235292256, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985746 Neighboring gene long intergenic non-protein coding RNA 1348 Neighboring gene uncharacterized LOC105379283 Neighboring gene small nucleolar RNA, H/ACA box 14B Neighboring gene RNA binding motif protein 34 Neighboring gene AT-rich interaction domain 4B Neighboring gene microRNA 4753

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Biological, clinical and population relevance of 95 loci for blood lipids.
NHGRI GWA Catalog
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 encephalitis infection upregulates TOM20 and TOM40 protein levels in post-mortem brain samples PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 ADA Env (gp120) relocalizes TOM20 into puncta on the dendrites of rat cortical neurons PubMed
env HIV-1 Env (gp120) upregulates TOM20 and TOM40 protein levels in transgenic mouse neurons PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Deubiquitination, organism-specific biosystem (from REACTOME)
    Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Mitochondrial protein import, organism-specific biosystem (from REACTOME)
    Mitochondrial protein import, organism-specific biosystemA human mitochondrion contains about 1500 proteins, more than 99% of which are encoded in the nucleus, synthesized in the cytosol and imported into the mitochondrion. Proteins are targeted to four lo...
  • Mitophagy, organism-specific biosystem (from REACTOME)
    Mitophagy, organism-specific biosystemMitophagy is a specific form of autophagy where mitochondria are specifically targeted for degradation by autophagolysosomes.. In mammals there are a number of known mechanisms of mitophagy. One insu...
  • Pink/Parkin Mediated Mitophagy, organism-specific biosystem (from REACTOME)
    Pink/Parkin Mediated Mitophagy, organism-specific biosystemThis is the process of selective removal of damaged mitochondria by autophagosomes and subsequent catabolism by lysosomes. In healthy mitochondria, PINK1 is imported to the inner mitochondrial membra...
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Ub-specific processing proteases, organism-specific biosystem (from REACTOME)
    Ub-specific processing proteases, organism-specific biosystemUb-specific processing proteases (USPs) are the largest of the DUB families with more than 50 members in humans. The USP catalytic domain varies considerably in size and consists of six conserved mo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0016, MGC117367

Gene Ontology Provided by GOA

Function Evidence Code Pubs
P-P-bond-hydrolysis-driven protein transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
P-P-bond-hydrolysis-driven protein transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion targeting sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to protein transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
unfolded protein binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
mitochondrial outer membrane translocase complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
protein import into mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein targeting to mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
response to 3,3',5-triiodo-L-thyronine IEA
Inferred from Electronic Annotation
more info
 
response to muscle activity IEA
Inferred from Electronic Annotation
more info
 
tRNA import into mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Mitochondria-associated ER Membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial outer membrane TAS
Traceable Author Statement
more info
 
mitochondrial outer membrane translocase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial outer membrane translocase complex NAS
Non-traceable Author Statement
more info
PubMed 
mitochondrial outer membrane translocase complex TAS
Traceable Author Statement
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mitochondrial import receptor subunit TOM20 homolog
Names
mitochondrial 20 kDa outer membrane protein
outer mitochondrial membrane receptor Tom20
translocase of outer mitochondrial membrane 20 homolog type II

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014765.3NP_055580.1  mitochondrial import receptor subunit TOM20 homolog

    See identical proteins and their annotated locations for NP_055580.1

    Status: VALIDATED

    Source sequence(s)
    AK289810, BC009886, BC100286, D13641
    Consensus CDS
    CCDS1603.1
    UniProtKB/Swiss-Prot
    Q15388
    UniProtKB/TrEMBL
    A0A024R3W2
    Related
    ENSP00000355566.4, ENST00000366607.4
    Conserved Domains (1) summary
    pfam02064
    Location:13124
    MAS20; MAS20 protein import receptor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    235109341..235128941 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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