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SERTAD2 SERTA domain containing 2 [ Homo sapiens (human) ]

Gene ID: 9792, updated on 5-Aug-2022

Summary

Official Symbol
SERTAD2provided by HGNC
Official Full Name
SERTA domain containing 2provided by HGNC
Primary source
HGNC:HGNC:30784
See related
Ensembl:ENSG00000179833 MIM:617851; AllianceGenome:HGNC:30784
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Sei-2; TRIPBR2; TRIP-Br2
Summary
Predicted to enable transcription coactivator activity. Acts upstream of or within negative regulation of cell growth. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 29.6), esophagus (RPKM 11.9) and 24 other tissues See more
Orthologs
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Genomic context

See SERTAD2 in Genome Data Viewer
Location:
2p14
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (64631621..64653913, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (64641067..64663350, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (64858755..64881047, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene aftiphilin Neighboring gene uncharacterized LOC105374773 Neighboring gene RNA, U6 small nuclear 100, pseudogene Neighboring gene long intergenic non-protein coding RNA 2579 Neighboring gene uncharacterized LOC105374775 Neighboring gene Sharpr-MPRA regulatory region 66 Neighboring gene uncharacterized LOC124907776 Neighboring gene ribosomal protein S10 pseudogene 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126688, MGC126690

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
SERTA domain-containing protein 2
Names
transcriptional regulator interacting with the PHD-bromodomain 2
transcriptional regulator interacting with the PHS-bromodomain 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014755.3NP_055570.1  SERTA domain-containing protein 2

    See identical proteins and their annotated locations for NP_055570.1

    Status: VALIDATED

    Source sequence(s)
    AC007365, BQ017415
    Consensus CDS
    CCDS33210.1
    UniProtKB/Swiss-Prot
    Q14140, Q53TS2
    Related
    ENSP00000326933.3, ENST00000313349.3
    Conserved Domains (1) summary
    pfam06031
    Location:4077
    SERTA; SERTA motif

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    64631621..64653913 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    64641067..64663350 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)