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SERTAD2 SERTA domain containing 2 [ Homo sapiens (human) ]

Gene ID: 9792, updated on 4-May-2020

Summary

Official Symbol
SERTAD2provided by HGNC
Official Full Name
SERTA domain containing 2provided by HGNC
Primary source
HGNC:HGNC:30784
See related
Ensembl:ENSG00000179833 MIM:617851
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Sei-2; TRIPBR2; TRIP-Br2
Expression
Ubiquitous expression in bone marrow (RPKM 29.6), esophagus (RPKM 11.9) and 24 other tissues See more
Orthologs

Genomic context

See SERTAD2 in Genome Data Viewer
Location:
2p14
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (64631621..64751086, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (64858755..64978048, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene aftiphilin Neighboring gene uncharacterized LOC105374772 Neighboring gene long intergenic non-protein coding RNA 2579 Neighboring gene uncharacterized LOC105374775 Neighboring gene ribosomal protein S10 pseudogene 9 Neighboring gene uncharacterized LOC105374777 Neighboring gene uncharacterized LOC105374776

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126688, MGC126690

Gene Ontology Provided by GOA

Function Evidence Code Pubs
transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
 
transcription regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
chromatin-mediated maintenance of transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
SERTA domain-containing protein 2
Names
transcriptional regulator interacting with the PHD-bromodomain 2
transcriptional regulator interacting with the PHS-bromodomain 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014755.3NP_055570.1  SERTA domain-containing protein 2

    See identical proteins and their annotated locations for NP_055570.1

    Status: VALIDATED

    Source sequence(s)
    AC007365, BQ017415
    Consensus CDS
    CCDS33210.1
    UniProtKB/Swiss-Prot
    Q14140
    Related
    ENSP00000326933.3, ENST00000313349.3
    Conserved Domains (1) summary
    pfam06031
    Location:4077
    SERTA; SERTA motif

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    64631621..64751086 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264669.3XP_005264726.1  SERTA domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005264726.1

    UniProtKB/Swiss-Prot
    Q14140
    Conserved Domains (1) summary
    pfam06031
    Location:4077
    SERTA; SERTA motif
  2. XM_011533205.2XP_011531507.1  SERTA domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011531507.1

    UniProtKB/Swiss-Prot
    Q14140
    Conserved Domains (1) summary
    pfam06031
    Location:4077
    SERTA; SERTA motif
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