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Sertad2 SERTA domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 58172, updated on 18-Apr-2024

Summary

Official Symbol
Sertad2provided by MGI
Official Full Name
SERTA domain containing 2provided by MGI
Primary source
MGI:MGI:1931026
See related
Ensembl:ENSMUSG00000049800 AllianceGenome:MGI:1931026
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sei2; SEI-2; Kiaa0127; TRIP-Br2; MNCb-1504; mKIAA0127
Summary
Enables transcription coactivator activity. Acts upstream of or within positive regulation of transcription, DNA-templated. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including 1st branchial arch; early conceptus; genitourinary system; nervous system; and sensory organ. Orthologous to human SERTAD2 (SERTA domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 23.4), lung adult (RPKM 9.5) and 28 other tissues See more
Orthologs
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Genomic context

Location:
11 A3.1; 11 13.03 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (20493166..20603023)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (20543166..20653023)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39606 Neighboring gene predicted gene, 39607 Neighboring gene predicted gene, 32142 Neighboring gene STARR-positive B cell enhancer ABC_E5208 Neighboring gene ribosomal protein L15 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6957 Neighboring gene aftiphilin Neighboring gene RIKEN cDNA 4930434J08 gene Neighboring gene STARR-seq mESC enhancer starr_28821 Neighboring gene STARR-seq mESC enhancer starr_28822 Neighboring gene STARR-positive B cell enhancer mm9_chr11:20694243-20694543 Neighboring gene predicted gene, 32213

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Gene trapped (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISA
Inferred from Sequence Alignment
more info
PubMed 

General protein information

Preferred Names
SERTA domain-containing protein 2
Names
PHD zinc finger- and bromodomain-interacting protein 2
transcriptional regulator interacting with the PHD-bromodomain 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038625.1NP_001033714.1  SERTA domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001033714.1

    Status: VALIDATED

    Source sequence(s)
    AK146621, AL663115
    Consensus CDS
    CCDS24458.1
    UniProtKB/Swiss-Prot
    Q8C609, Q91WL3, Q925E5, Q9JJG5
    UniProtKB/TrEMBL
    Q3UGZ1
    Related
    ENSMUSP00000105215.3, ENSMUST00000109586.3
    Conserved Domains (1) summary
    pfam06031
    Location:4075
    SERTA; SERTA motif
  2. NM_001362867.1NP_001349796.1  SERTA domain-containing protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK147674, AL663115
    Conserved Domains (1) summary
    pfam06031
    Location:4681
    SERTA; SERTA motif
  3. NM_021372.3NP_067347.2  SERTA domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_067347.2

    Status: VALIDATED

    Source sequence(s)
    AK142268, AK147674, AL663115
    Consensus CDS
    CCDS24458.1
    UniProtKB/Swiss-Prot
    Q8C609, Q91WL3, Q925E5, Q9JJG5
    UniProtKB/TrEMBL
    Q3UGZ1
    Related
    ENSMUSP00000090981.5, ENSMUST00000093292.11
    Conserved Domains (1) summary
    pfam06031
    Location:4075
    SERTA; SERTA motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    20493166..20603023
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156871.1XP_036012764.1  SERTA domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8C609, Q91WL3, Q925E5, Q9JJG5
    UniProtKB/TrEMBL
    Q3UGZ1
    Conserved Domains (1) summary
    pfam06031
    Location:4075
    SERTA; SERTA motif
  2. XM_006514766.5XP_006514829.1  SERTA domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006514829.1

    UniProtKB/Swiss-Prot
    Q8C609, Q91WL3, Q925E5, Q9JJG5
    UniProtKB/TrEMBL
    Q3UGZ1
    Related
    ENSMUSP00000105214.2, ENSMUST00000109585.2
    Conserved Domains (1) summary
    pfam06031
    Location:4075
    SERTA; SERTA motif