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RNF144A ring finger protein 144A [ Homo sapiens (human) ]

Gene ID: 9781, updated on 1-Jun-2020

Summary

Official Symbol
RNF144Aprovided by HGNC
Official Full Name
ring finger protein 144Aprovided by HGNC
Primary source
HGNC:HGNC:20457
See related
Ensembl:ENSG00000151692
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hUIP4; RNF144; UBCE7IP4
Summary
This gene encodes a member of a family of RING finger domain-containing E3 ubiquitin ligases that also includes parkin and parc. The expression of this gene is induced by DNA damage. The encoded protein interacts with the cytoplasmic DNA-dependent protein kinase, catalytic subunit (DNA-PKcs) and promotes its degradation through ubiquitination. The orthologous mouse protein has been shown to interact with a ubiquitin-conjugating enzyme involved in embryonic development. [provided by RefSeq, Mar 2017]
Expression
Ubiquitous expression in adrenal (RPKM 4.0), endometrium (RPKM 3.6) and 24 other tissues See more
Orthologs

Genomic context

See RNF144A in Genome Data Viewer
Location:
2p25.1
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (6917412..7076886)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (7057523..7209011)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene negative regulator of interferon response Neighboring gene cytidine/uridine monophosphate kinase 2 Neighboring gene radical S-adenosyl methionine domain containing 2 Neighboring gene glycosaminoglycan regulatory associated long non-coding RNA Neighboring gene Sharpr-MPRA regulatory region 7427/13434 Neighboring gene uncharacterized LOC101929452 Neighboring gene RN7SK pseudogene 112 Neighboring gene cyclin-dependent kinase 2-associated protein 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0161

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase activity EXP
Inferred from Experiment
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination TAS
Traceable Author Statement
more info
 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
endosome membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNF144A
Names
UbcM4-interacting protein 4
probable E3 ubiquitin-protein ligase RNF144A
ring finger protein 144
ubiquitin conjugating enzyme 7 interacting protein 4
NP_001336110.1
NP_001336111.1
NP_001336112.1
NP_001336113.1
NP_001336114.1
NP_001336115.1
NP_055561.2
XP_005246259.1
XP_016860887.1
XP_016860889.1
XP_016860890.1
XP_016860891.1
XP_016860892.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001349181.2NP_001336110.1  E3 ubiquitin-protein ligase RNF144A isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC017076, AC019048, AC068481, KF456627
    Conserved Domains (3) summary
    smart00647
    Location:91156
    IBR; In Between Ring fingers
    pfam01485
    Location:177216
    IBR; IBR domain, a half RING-finger domain
    cd16777
    Location:1972
    mRING-HC-C4C4_RBR_RNF144A; Modified RING finger, HC subclass (C4C4-type), found in RING finger protein 144A (RNF144A)
  2. NM_001349182.2NP_001336111.1  E3 ubiquitin-protein ligase RNF144A isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' and 3' UTRs and the 3' coding region compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1. Variants 2-5 encode the same isoform (2).
    Source sequence(s)
    AC068481, KF456627
    Consensus CDS
    CCDS1657.1
    Conserved Domains (3) summary
    smart00647
    Location:91156
    IBR; In Between Ring fingers
    pfam01485
    Location:177216
    IBR; IBR domain, a half RING-finger domain
    cd16777
    Location:1972
    mRING-HC-C4C4_RBR_RNF144A; Modified RING finger, HC subclass (C4C4-type), found in RING finger protein 144A (RNF144A)
  3. NM_001349183.2NP_001336112.1  E3 ubiquitin-protein ligase RNF144A isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' and 3' UTRs and the 3' coding region compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1. Variants 2-5 encode the same isoform (2).
    Source sequence(s)
    AC068481, KF456627
    Consensus CDS
    CCDS1657.1
    Conserved Domains (3) summary
    smart00647
    Location:91156
    IBR; In Between Ring fingers
    pfam01485
    Location:177216
    IBR; IBR domain, a half RING-finger domain
    cd16777
    Location:1972
    mRING-HC-C4C4_RBR_RNF144A; Modified RING finger, HC subclass (C4C4-type), found in RING finger protein 144A (RNF144A)
  4. NM_001349184.1NP_001336113.1  E3 ubiquitin-protein ligase RNF144A isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' and 3' UTRs and the 3' coding region compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1. Variants 2-5 encode the same isoform (2).
    Source sequence(s)
    AC017076, AC068481, AW662667, KF456627
    Consensus CDS
    CCDS1657.1
    Conserved Domains (3) summary
    smart00647
    Location:91156
    IBR; In Between Ring fingers
    pfam01485
    Location:177216
    IBR; IBR domain, a half RING-finger domain
    cd16777
    Location:1972
    mRING-HC-C4C4_RBR_RNF144A; Modified RING finger, HC subclass (C4C4-type), found in RING finger protein 144A (RNF144A)
  5. NM_001349185.2NP_001336114.1  E3 ubiquitin-protein ligase RNF144A isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 3' coding region and 3' UTR compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC017076, AC019048, AC068481, KF456627
    Conserved Domains (3) summary
    smart00647
    Location:91156
    IBR; In Between Ring fingers
    pfam01485
    Location:177216
    IBR; IBR domain, a half RING-finger domain
    cd16777
    Location:1972
    mRING-HC-C4C4_RBR_RNF144A; Modified RING finger, HC subclass (C4C4-type), found in RING finger protein 144A (RNF144A)
  6. NM_001349186.2NP_001336115.1  E3 ubiquitin-protein ligase RNF144A isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' and 3' UTRs, has multiple coding region differences, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC017076, AC068481, KF456627
    Conserved Domains (2) summary
    smart00647
    Location:873
    IBR; In Between Ring fingers
    pfam01485
    Location:94133
    IBR; IBR domain, a half RING-finger domain
  7. NM_014746.6NP_055561.2  E3 ubiquitin-protein ligase RNF144A isoform 2

    See identical proteins and their annotated locations for NP_055561.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1. Variants 2-5 encode the same isoform (2).
    Source sequence(s)
    AC017076, AC068481, BC050373
    Consensus CDS
    CCDS1657.1
    UniProtKB/Swiss-Prot
    P50876
    Related
    ENSP00000321330.6, ENST00000320892.11
    Conserved Domains (3) summary
    smart00647
    Location:91156
    IBR; In Between Ring fingers
    pfam01485
    Location:177216
    IBR; IBR domain, a half RING-finger domain
    cd16777
    Location:1972
    mRING-HC-C4C4_RBR_RNF144A; Modified RING finger, HC subclass (C4C4-type), found in RING finger protein 144A (RNF144A)

RNA

  1. NR_146069.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) uses an alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because it lacks the entire coding region found in variant 1.
    Source sequence(s)
    BC035051

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    6917412..7076886
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005402.2XP_016860891.1  E3 ubiquitin-protein ligase RNF144A isoform X3

  2. XM_017005400.2XP_016860889.1  E3 ubiquitin-protein ligase RNF144A isoform X2

    Related
    ENSP00000411616.1, ENST00000432850.1
    Conserved Domains (3) summary
    smart00647
    Location:91156
    IBR; In Between Ring fingers
    pfam01485
    Location:177216
    IBR; IBR domain, a half RING-finger domain
    cd16777
    Location:1972
    mRING-HC-C4C4_RBR_RNF144A; Modified RING finger, HC subclass (C4C4-type), found in RING finger protein 144A (RNF144A)
  3. XM_017005403.2XP_016860892.1  E3 ubiquitin-protein ligase RNF144A isoform X4

  4. XM_017005398.2XP_016860887.1  E3 ubiquitin-protein ligase RNF144A isoform X2

    Conserved Domains (3) summary
    smart00647
    Location:91156
    IBR; In Between Ring fingers
    pfam01485
    Location:177216
    IBR; IBR domain, a half RING-finger domain
    cd16777
    Location:1972
    mRING-HC-C4C4_RBR_RNF144A; Modified RING finger, HC subclass (C4C4-type), found in RING finger protein 144A (RNF144A)
  5. XM_017005401.2XP_016860890.1  E3 ubiquitin-protein ligase RNF144A isoform X3

  6. XM_005246202.4XP_005246259.1  E3 ubiquitin-protein ligase RNF144A isoform X1

    See identical proteins and their annotated locations for XP_005246259.1

    UniProtKB/Swiss-Prot
    P50876
    Conserved Domains (3) summary
    smart00647
    Location:91156
    IBR; In Between Ring fingers
    pfam01485
    Location:177216
    IBR; IBR domain, a half RING-finger domain
    cd16777
    Location:1972
    mRING-HC-C4C4_RBR_RNF144A; Modified RING finger, HC subclass (C4C4-type), found in RING finger protein 144A (RNF144A)

RNA

  1. XR_001739082.1 RNA Sequence

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