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CDA cytidine deaminase [ Homo sapiens (human) ]

Gene ID: 978, updated on 11-Sep-2019

Summary

Official Symbol
CDAprovided by HGNC
Official Full Name
cytidine deaminaseprovided by HGNC
Primary source
HGNC:HGNC:1712
See related
Ensembl:ENSG00000158825 MIM:123920
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDD
Summary
This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. [provided by RefSeq, Jul 2008]
Expression
Biased expression in bone marrow (RPKM 57.6), esophagus (RPKM 22.6) and 8 other tissues See more
Orthologs

Genomic context

See CDA in Genome Data Viewer
Location:
1p36.12
Exon count:
4
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (20589097..20618903)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (20915444..20945401)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S4X pseudogene 4 Neighboring gene family with sequence similarity 43 member B Neighboring gene microRNA 6084 Neighboring gene PTEN induced kinase 1 Neighboring gene PINK1 antisense RNA Neighboring gene dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytidine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytidine deaminase activity IDA
Inferred from Direct Assay
more info
PubMed 
nucleoside binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cell surface receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
cytidine deamination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytidine deamination IDA
Inferred from Direct Assay
more info
PubMed 
cytosine metabolic process TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of nucleotide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
protein homotetramerization IDA
Inferred from Direct Assay
more info
PubMed 
pyrimidine nucleoside salvage TAS
Traceable Author Statement
more info
 
pyrimidine-containing compound salvage NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol NAS
Non-traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
PubMed 
ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
secretory granule lumen TAS
Traceable Author Statement
more info
 
tertiary granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
cytidine deaminase
Names
cytidine aminohydrolase
cytosine nucleoside deaminase
small cytidine deaminase
NP_001776.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001785.3NP_001776.1  cytidine deaminase

    See identical proteins and their annotated locations for NP_001776.1

    Status: REVIEWED

    Source sequence(s)
    BC054036, CD675458
    Consensus CDS
    CCDS210.1
    UniProtKB/Swiss-Prot
    P32320
    Related
    ENSP00000364212.3, ENST00000375071.4
    Conserved Domains (1) summary
    TIGR01354
    Location:16142
    cyt_deam_tetra; cytidine deaminase, homotetrameric

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    20589097..20618903
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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