Format

Send to:

Choose Destination

MLEC malectin [ Homo sapiens (human) ]

Gene ID: 9761, updated on 9-Feb-2020

Summary

Official Symbol
MLECprovided by HGNC
Official Full Name
malectinprovided by HGNC
Primary source
HGNC:HGNC:28973
See related
Ensembl:ENSG00000110917 MIM:613802
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIAA0152
Summary
This gene encodes the carbohydrate-binding protein malectin which is a Type I membrane-anchored endoplasmic reticulum protein. This protein has an affinity for Glc2Man9GlcNAc2 (G2M9) N-glycans and is involved in regulating glycosylation in the endoplasmic reticulum. This protein has also been shown to interact with ribophorin I and may be involved in the directing the degradation of misfolded proteins. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Expression
Ubiquitous expression in colon (RPKM 16.3), thyroid (RPKM 15.6) and 25 other tissues See more
Orthologs

Genomic context

See MLEC in Genome Data Viewer
Location:
12q24.31
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (120687149..120701864)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (121124949..121139667)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928300 Neighboring gene calcium binding protein 1 Neighboring gene uncharacterized LOC105370029 Neighboring gene unc-119 lipid binding chaperone B Neighboring gene microRNA 4700 Neighboring gene acyl-CoA dehydrogenase short chain

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0152

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
protein folding TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
specific granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
malectin
Names
oligosaccharyltransferase complex subunit (non-catalytic)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303627.1NP_001290556.1  malectin isoform 2

    See identical proteins and their annotated locations for NP_001290556.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate exon in the 5' UTR and coding region which results in the use of a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AA831396, AC069234, BI458950
    Conserved Domains (1) summary
    pfam11721
    Location:9125
    Malectin; Di-glucose binding within endoplasmic reticulum
  2. NM_001303628.2NP_001290557.1  malectin isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two consecutive exon in the central coding region which results in a frameshift compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus compare to isoform 1.
    Source sequence(s)
    AA831396, AC069234, BE326824, BG718506
    Consensus CDS
    CCDS76609.1
    UniProtKB/TrEMBL
    F5GX14
    Related
    ENSP00000440746.1, ENST00000412616.2
    Conserved Domains (1) summary
    pfam11721
    Location:48135
    Malectin; Di-glucose binding within endoplasmic reticulum
  3. NM_014730.4NP_055545.1  malectin isoform1 precursor

    See identical proteins and their annotated locations for NP_055545.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA831396, AC069234, BC016297, BG718506
    Consensus CDS
    CCDS9206.1
    UniProtKB/Swiss-Prot
    Q14165
    Related
    ENSP00000228506.3, ENST00000228506.8
    Conserved Domains (1) summary
    pfam11721
    Location:48208
    Malectin; Di-glucose binding within endoplasmic reticulum

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    120687149..120701864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539031.1XP_011537333.1  malectin isoform X1

    See identical proteins and their annotated locations for XP_011537333.1

    Conserved Domains (1) summary
    pfam11721
    Location:9125
    Malectin; Di-glucose binding within endoplasmic reticulum
  2. XM_011539032.1XP_011537334.1  malectin isoform X1

    See identical proteins and their annotated locations for XP_011537334.1

    Conserved Domains (1) summary
    pfam11721
    Location:9125
    Malectin; Di-glucose binding within endoplasmic reticulum
Support Center