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Mlec malectin [ Mus musculus (house mouse) ]

Gene ID: 109154, updated on 2-Nov-2024

Summary

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Official Symbol
Mlecprovided by MGI
Official Full Name
malectinprovided by MGI
Primary source
MGI:MGI:1924015
See related
Ensembl:ENSMUSG00000048578 AllianceGenome:MGI:1924015
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ESTM19; mKIAA0152; 2410014A08Rik
Summary
Predicted to enable carbohydrate binding activity and enzyme binding activity. Predicted to be involved in protein N-linked glycosylation. Predicted to be located in endoplasmic reticulum. Predicted to be part of oligosaccharyltransferase complex. Predicted to be active in membrane. Is expressed in clavicle; craniocervical region bone; inner ear; lung; and submandibular gland primordium. Orthologous to human MLEC (malectin). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in kidney adult (RPKM 84.5), large intestine adult (RPKM 68.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mlec in Genome Data Viewer
Location:
5 F; 5 55.99 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (115281040..115296235, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (115142981..115158176, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene acyl-Coenzyme A dehydrogenase, short chain Neighboring gene unc-119 lipid binding chaperone B Neighboring gene STARR-positive B cell enhancer ABC_E10342 Neighboring gene STARR-seq mESC enhancer starr_14100 Neighboring gene STARR-positive B cell enhancer ABC_E1058 Neighboring gene STARR-seq mESC enhancer starr_14105 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:115617496-115617679 Neighboring gene calcium binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_14108 Neighboring gene STARR-seq mESC enhancer starr_14109 Neighboring gene predicted gene, 35515 Neighboring gene STARR-seq mESC enhancer starr_14111 Neighboring gene STARR-positive B cell enhancer ABC_E8072 Neighboring gene processing of precursor 5, ribonuclease P/MRP family (S. cerevisiae)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular characterization of mutant mouse strains generated from the EUCOMM/KOMP-CSD ES cell resource. Ryder E, et al. Mamm Genome, 2013 Aug. PMID 23912999, Free PMC Article
  2. Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B. Ramírez AS, et al. Science, 2019 Dec 13. PMID 31831667
  3. Genetic mapping of 20 novel expressed sequence tags from midgestation mouse embryos suggests chromosomal clustering. Tchernev VT, et al. Genomics, 1997 Feb 15. PMID 9070936
  4. Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Bettenhausen B, et al. Genomics, 1995 Aug 10. PMID 7490078
  5. A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. Nakano Y, et al. PLoS Genet, 2012. PMID 23055939, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC32493

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables enzyme binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein N-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein N-linked glycosylation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of oligosaccharyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
part_of oligosaccharyltransferase complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
malectin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175403.3 → NP_780612.2  malectin precursor

    See identical proteins and their annotated locations for NP_780612.2

    Status: VALIDATED

    Source sequence(s)
    AK031525, AK129066, BU703535, CJ093242, DV061883
    Consensus CDS
    CCDS19581.1
    UniProtKB/Swiss-Prot
    Q6ZQI3, Q8C6C3, Q8CD40, Q8CI91
    Related
    ENSMUSP00000107749.3, ENSMUST00000112121.6
    Conserved Domains (1) summary
    pfam11721
    Location:47 → 207
    Malectin; Di-glucose binding within endoplasmic reticulum

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    115281040..115296235 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164725.1 → XP_036020618.1  malectin isoform X1

    Conserved Domains (1) summary
    pfam11721
    Location:10 → 125
    Malectin; Di-glucose binding within endoplasmic reticulum

  2. XM_036164726.1 → XP_036020619.1  malectin isoform X1

    Conserved Domains (1) summary
    pfam11721
    Location:10 → 125
    Malectin; Di-glucose binding within endoplasmic reticulum
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZQI3.2 GenPept UniProtKB/Swiss-Prot:Q6ZQI3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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