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TOX thymocyte selection associated high mobility group box [ Homo sapiens (human) ]

Gene ID: 9760, updated on 16-Aug-2021

Summary

Official Symbol
TOXprovided by HGNC
Official Full Name
thymocyte selection associated high mobility group boxprovided by HGNC
Primary source
HGNC:HGNC:18988
See related
Ensembl:ENSG00000198846 MIM:606863
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TOX1
Summary
The protein encoded by this gene contains a HMG box DNA binding domain. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. This protein may function to regulate T-cell development.[provided by RefSeq, Apr 2009]
Expression
Broad expression in lymph node (RPKM 9.9), brain (RPKM 6.2) and 19 other tissues See more
Orthologs
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Genomic context

See TOX in Genome Data Viewer
Location:
8q12.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (58805412..59119147, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (59717971..60031706, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S26 pseudogene 7 Neighboring gene neutral sphingomyelinase activation associated factor Neighboring gene uncharacterized LOC105375858 Neighboring gene Sharpr-MPRA regulatory region 1495 Neighboring gene RNA, U4 small nuclear 50, pseudogene Neighboring gene VISTA enhancer hs1326 Neighboring gene uncharacterized LOC100505501 Neighboring gene RNA, 5S ribosomal pseudogene 267

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.
GeneReviews: Not available
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
GeneReviews: Not available
Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium.
GeneReviews: Not available
Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.
GeneReviews: Not available
Genome-wide meta-analysis of myopia and hyperopia provides evidence for replication of 11 Loci.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0808

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chromatin DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in CD4-positive, alpha-beta T cell lineage commitment ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in CD8-positive, alpha-beta T cell lineage commitment ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in NK T cell lineage commitment ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in Peyer's patch development IEA
Inferred from Electronic Annotation
more info
 
involved_in cerebral cortex neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in leukocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lymph node development IEA
Inferred from Electronic Annotation
more info
 
involved_in natural killer cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA demethylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of natural killer cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neural precursor cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of positive thymic T cell selection ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
thymocyte selection-associated high mobility group box protein TOX
Names
thymus high mobility group box protein TOX

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011993.1 RefSeqGene

    Range
    5062..318797
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_014729.3NP_055544.1  thymocyte selection-associated high mobility group box protein TOX

    See identical proteins and their annotated locations for NP_055544.1

    Status: REVIEWED

    Source sequence(s)
    AB018351, AC091195, CA439630
    Consensus CDS
    CCDS34897.1
    UniProtKB/Swiss-Prot
    O94900
    Related
    ENSP00000354842.1, ENST00000361421.2
    Conserved Domains (2) summary
    COG5648
    Location:257360
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd00084
    Location:261310
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    58805412..59119147 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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