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Tox thymocyte selection-associated high mobility group box [ Mus musculus (house mouse) ]

Gene ID: 252838, updated on 10-Jan-2023

Summary

Official Symbol
Toxprovided by MGI
Official Full Name
thymocyte selection-associated high mobility group boxprovided by MGI
Primary source
MGI:MGI:2181659
See related
Ensembl:ENSMUSG00000041272 AllianceGenome:MGI:2181659
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700007F02Rik
Summary
Enables chromatin DNA binding activity. Involved in several processes, including alpha-beta T cell lineage commitment; positive regulation of DNA demethylation; and regulation of positive thymic T cell selection. Acts upstream of or within hematopoietic or lymphoid organ development and positive regulation of natural killer cell differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skeleton. Orthologous to human TOX (thymocyte selection associated high mobility group box). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 22.1), whole brain E14.5 (RPKM 7.5) and 16 other tissues See more
Orthologs
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Genomic context

See Tox in Genome Data Viewer
Location:
4; 4 A1
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (6686353..6991557, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (6686353..6991557, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11801 Neighboring gene predicted gene, 22473 Neighboring gene predicted gene 11802 Neighboring gene predicted gene, 33462 Neighboring gene predicted gene, 33539

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0808

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chromatin DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in CD4-positive, alpha-beta T cell lineage commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in CD8-positive, alpha-beta T cell lineage commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in NK T cell lineage commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within Peyer's patch development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cerebral cortex neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in leukocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within lymph node development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lymphocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in natural killer cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA demethylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of natural killer cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neural precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of positive thymic T cell selection IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
thymocyte selection-associated high mobility group box protein TOX
Names
thymocyte selection-associated HMG box
thymus high mobility group box protein TOX

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001377078.1NP_001364007.1  thymocyte selection-associated high mobility group box protein TOX

    Status: VALIDATED

    Source sequence(s)
    AL671871, AL831740
    UniProtKB/Swiss-Prot
    Q8R4H0
    Conserved Domains (2) summary
    COG5648
    Location:257360
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd00084
    Location:261310
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
  2. NM_001377079.1NP_001364008.1  thymocyte selection-associated high mobility group box protein TOX

    Status: VALIDATED

    Source sequence(s)
    AL671871, AL831740
    UniProtKB/Swiss-Prot
    Q8R4H0
    Conserved Domains (2) summary
    COG5648
    Location:257360
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd00084
    Location:261310
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
  3. NM_145711.5NP_663757.3  thymocyte selection-associated high mobility group box protein TOX

    See identical proteins and their annotated locations for NP_663757.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All 3 variants encode the same protein.
    Source sequence(s)
    AL671871, AL831740
    Consensus CDS
    CCDS17953.1
    UniProtKB/Swiss-Prot
    Q66JW3, Q8R4H0
    Related
    ENSMUSP00000037966.4, ENSMUST00000039987.4
    Conserved Domains (2) summary
    COG5648
    Location:257360
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd00084
    Location:261310
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    6686353..6991557 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320230.2XP_017175719.1  thymocyte selection-associated high mobility group box protein TOX isoform X1

    Conserved Domains (2) summary
    COG5648
    Location:218321
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd00084
    Location:222271
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...