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ARHGAP32 Rho GTPase activating protein 32 [ Homo sapiens (human) ]

Gene ID: 9743, updated on 7-Oct-2018

Summary

Official Symbol
ARHGAP32provided by HGNC
Official Full Name
Rho GTPase activating protein 32provided by HGNC
Primary source
HGNC:HGNC:17399
See related
Ensembl:ENSG00000134909 MIM:608541; Vega:OTTHUMG00000165774
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GRIT; RICS; GC-GAP; PX-RICS; p250GAP; p200RhoGAP
Summary
RICS is a neuron-associated GTPase-activating protein that may regulate dendritic spine morphology and strength by modulating Rho GTPase (see RHOA; MIM 165390) activity (Okabe et al., 2003 [PubMed 12531901]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in brain (RPKM 12.5), esophagus (RPKM 7.8) and 22 other tissues See more
Orthologs

Genomic context

See ARHGAP32 in Genome Data Viewer
Location:
11q24.3
Exon count:
29
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (128965060..129279167, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (128834955..129062093, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene chromosome 11 open reading frame 45 Neighboring gene potassium voltage-gated channel subfamily J member 5 Neighboring gene tumor protein p53 regulated apoptosis inducing protein 1 Neighboring gene RNA, U6 small nuclear 876, pseudogene Neighboring gene RNA, U6 small nuclear 874, pseudogene Neighboring gene uncharacterized LOC399975 Neighboring gene HNF4 motif-containing MPRA enhancer 230 Neighboring gene uncharacterized LOC105369571 Neighboring gene zinc finger protein 123, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of Rho GTPase activating protein 32 (ARHGAP32; RICS) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
    Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC1892, KIAA0712

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activator activity TAS
Traceable Author Statement
more info
 
phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
small GTPase mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
dendritic spine IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
endosome membrane IEA
Inferred from Electronic Annotation
more info
 
fibrillar center IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fibrillar center IDA
Inferred from Direct Assay
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
rho GTPase-activating protein 32
Names
GAB-associated CDC42
GAB-associated Cdc42/Rac GTPase-activating protein
GTPase regulator interacting with TrkA
GTPase-activating protein for Cdc42 and Rac1
RhoGAP involved in the -catenin-N-cadherin and NMDA receptor signaling
brain-specific Rho GTP-ase-activating protein
brain-specific Rho GTPase-activating protein
rac GTPase activating protein
rho-type GTPase-activating protein 32
rho/Cdc42/Rac GTPase-activating protein RICS
rhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142685.1NP_001136157.1  rho GTPase-activating protein 32 isoform 1

    See identical proteins and their annotated locations for NP_001136157.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). This isoform is also known as PX-RICS.
    Source sequence(s)
    AL833062, AP000751, CK823137, EF127492
    Consensus CDS
    CCDS44769.1
    UniProtKB/Swiss-Prot
    A7KAX9
    UniProtKB/TrEMBL
    Q86T64
    Related
    ENSP00000310561.8, OTTHUMP00000230948, ENST00000310343.13, OTTHUMT00000386151
    Conserved Domains (3) summary
    cd07298
    Location:127241
    PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS
    cd11835
    Location:263316
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:368562
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
  2. NM_014715.3NP_055530.2  rho GTPase-activating protein 32 isoform 2

    See identical proteins and their annotated locations for NP_055530.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks multiple exons in the 5' UTR and 5' coding region and has a unique exon for its 5' UTR, compared to variant 1. These differences cause translation initiation from a downstream in-frame start codon. The encoded protein (isoform 2) has a shorter N-terminus which lacks phox homology and src homology 3 domains, compared to isoform 1.
    Source sequence(s)
    AB079856, AP000751, BQ319051, EF127492
    Consensus CDS
    CCDS31718.1
    UniProtKB/Swiss-Prot
    A7KAX9
    Related
    ENSP00000376425.3, OTTHUMP00000230996, ENST00000392657.7, OTTHUMT00000386249
    Conserved Domains (1) summary
    cd04384
    Location:19213
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    128965060..129279167 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018595.2XP_016874084.1  rho GTPase-activating protein 32 isoform X3

    Conserved Domains (3) summary
    cd07298
    Location:101215
    PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS
    cd11835
    Location:237290
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:342536
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
  2. XM_011543072.2XP_011541374.1  rho GTPase-activating protein 32 isoform X3

    See identical proteins and their annotated locations for XP_011541374.1

    Conserved Domains (3) summary
    cd07298
    Location:101215
    PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS
    cd11835
    Location:237290
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:342536
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
  3. XM_005271736.4XP_005271793.2  rho GTPase-activating protein 32 isoform X1

    Conserved Domains (3) summary
    cd07298
    Location:141255
    PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS
    cd11835
    Location:277330
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:382576
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
  4. XM_011543073.2XP_011541375.2  rho GTPase-activating protein 32 isoform X2

  5. XM_017018596.1XP_016874085.1  rho GTPase-activating protein 32 isoform X4

  6. XM_011543075.2XP_011541377.1  rho GTPase-activating protein 32 isoform X5

    Conserved Domains (1) summary
    cd04384
    Location:43237
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
  7. XM_017018597.2XP_016874086.1  rho GTPase-activating protein 32 isoform X6

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