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CCP110 centriolar coiled-coil protein 110 [ Homo sapiens (human) ]

Gene ID: 9738, updated on 8-Jul-2021

Summary

Official Symbol
CCP110provided by HGNC
Official Full Name
centriolar coiled-coil protein 110provided by HGNC
Primary source
HGNC:HGNC:24342
See related
Ensembl:ENSG00000103540 MIM:609544
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CP110; Cep110
Expression
Broad expression in testis (RPKM 21.6), brain (RPKM 10.5) and 22 other tissues See more
Orthologs
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Genomic context

See CCP110 in Genome Data Viewer
Location:
16p12.3
Exon count:
17
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (19523879..19553408)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (19535264..19564730)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene transmembrane channel like 5 Neighboring gene RNA, U4 small nuclear 46, pseudogene Neighboring gene glycerophosphodiester phosphodiesterase 1 Neighboring gene VPS35 endosomal protein sorting factor like Neighboring gene lysine rich nucleolar protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0419, DKFZp781G1416

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in centriole replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in centriole replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in centrosome duplication IDA
Inferred from Direct Assay
more info
PubMed 
involved_in centrosome duplication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ciliary basal body organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ciliary basal body organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of centriole elongation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in centriole IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
centriolar coiled-coil protein of 110 kDa
Names
centriolar coiled-coil protein 110kDa
centrosomal protein CP110
centrosomal protein of 110 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199022.3NP_001185951.2  centriolar coiled-coil protein of 110 kDa isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC012621, BC036654, BQ632514, BY798911, CN307903, CN307908, CR749255, DA250590
    Consensus CDS
    CCDS55992.1
    UniProtKB/Swiss-Prot
    O43303
    Related
    ENSP00000370803.5, ENST00000381396.9
    Conserved Domains (1) summary
    pfam16025
    Location:29125
    CALM_bind; Calcium-dependent calmodulin binding
  2. NM_001323569.2NP_001310498.1  centriolar coiled-coil protein of 110 kDa isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC012621
    Consensus CDS
    CCDS55992.1
    UniProtKB/Swiss-Prot
    O43303
    Conserved Domains (1) summary
    pfam16025
    Location:29125
    CALM_bind; Calcium-dependent calmodulin binding
  3. NM_001323570.2NP_001310499.1  centriolar coiled-coil protein of 110 kDa isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC012621
    Consensus CDS
    CCDS10579.1
    UniProtKB/Swiss-Prot
    O43303
  4. NM_001323571.2NP_001310500.1  centriolar coiled-coil protein of 110 kDa isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC012621
    Consensus CDS
    CCDS10579.1
    UniProtKB/Swiss-Prot
    O43303
  5. NM_001323572.2NP_001310501.1  centriolar coiled-coil protein of 110 kDa isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC012621
    Consensus CDS
    CCDS10579.1
    UniProtKB/Swiss-Prot
    O43303
    Related
    ENSP00000379511.2, ENST00000396208.3
  6. NM_001323576.2NP_001310505.1  centriolar coiled-coil protein of 110 kDa isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC012621
    Conserved Domains (1) summary
    pfam16025
    Location:29125
    CALM_bind; Calcium-dependent calmodulin binding
  7. NM_001323577.2NP_001310506.1  centriolar coiled-coil protein of 110 kDa isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC012621
    Conserved Domains (1) summary
    pfam16025
    Location:29125
    CALM_bind; Calcium-dependent calmodulin binding
  8. NM_014711.6NP_055526.4  centriolar coiled-coil protein of 110 kDa isoform 2

    Status: VALIDATED

    Source sequence(s)
    AB007879, AC012621, BC036654, BP360952, BY798911, CB066937, DA370828, DB504255
    Consensus CDS
    CCDS10579.1
    UniProtKB/Swiss-Prot
    O43303
    Related
    ENSP00000379515.2, ENST00000396212.6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    19523879..19553408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023908.1XP_016879397.1  centriolar coiled-coil protein of 110 kDa isoform X1

    UniProtKB/Swiss-Prot
    O43303
    Conserved Domains (1) summary
    pfam16025
    Location:29125
    CALM_bind; Calcium-dependent calmodulin binding
  2. XM_011545991.2XP_011544293.1  centriolar coiled-coil protein of 110 kDa isoform X1

    See identical proteins and their annotated locations for XP_011544293.1

    UniProtKB/Swiss-Prot
    O43303
    Conserved Domains (1) summary
    pfam16025
    Location:29125
    CALM_bind; Calcium-dependent calmodulin binding
  3. XM_011545992.2XP_011544294.1  centriolar coiled-coil protein of 110 kDa isoform X1

    See identical proteins and their annotated locations for XP_011544294.1

    UniProtKB/Swiss-Prot
    O43303
    Conserved Domains (1) summary
    pfam16025
    Location:29125
    CALM_bind; Calcium-dependent calmodulin binding
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