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CCP110 centriolar coiled-coil protein 110 [ Homo sapiens (human) ]

Gene ID: 9738, updated on 18-May-2023

Summary

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Official Symbol
CCP110provided by HGNC
Official Full Name
centriolar coiled-coil protein 110provided by HGNC
Primary source
HGNC:HGNC:24342
See related
Ensembl:ENSG00000103540 MIM:609544; AllianceGenome:HGNC:24342
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CP110; Cep110
Summary
Involved in centriole replication; negative regulation of cilium assembly; and regulation of cytokinesis. Located in centriole and centrosome. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 21.6), brain (RPKM 10.5) and 22 other tissues See more
Orthologs
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Genomic context

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See CCP110 in Genome Data Viewer
Location:
16p12.3
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (19523942..19553408)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (19454815..19484280)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (19535264..19564730)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene transmembrane channel like 5 Neighboring gene RNA, U4 small nuclear 46, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:19532887-19533621 Neighboring gene glycerophosphodiester phosphodiesterase 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:19566659-19567621 Neighboring gene VPS35 endosomal protein sorting factor like Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:19620544-19621743

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. LUBAC regulates ciliogenesis by promoting CP110 removal from the mother centriole. Shen XL, et al. J Cell Biol, 2022 Jan 3. PMID 34813648, Free PMC Article
  2. Inflammation-mediated upregulation of centrosomal protein 110, a negative modulator of ciliogenesis, in patients with chronic rhinosinusitis. Lai Y, et al. J Allergy Clin Immunol, 2011 Dec. PMID 21982113
  3. Centrioles want to move out and make cilia. Pearson CG, et al. Dev Cell, 2007 Sep. PMID 17765674
  4. Myeloid/lymphoid neoplasm with CEP110-FGFR1 fusion: An analysis of 16 cases show common features and poor prognosis. Chen M, et al. Hematology, 2021 Dec. PMID 33491601
  5. PLK4 phosphorylation of CP110 is required for efficient centriole assembly. Lee M, et al. Cell Cycle, 2017 Jun 18. PMID 28562169, Free PMC Article

See all (90) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Primary cilia biogenesis and associated retinal ciliopathies.
    Title: Primary cilia biogenesis and associated retinal ciliopathies.
  2. LUBAC regulates ciliogenesis by promoting CP110 removal from the mother centriole.
    Title: LUBAC regulates ciliogenesis by promoting CP110 removal from the mother centriole.
  3. CEP78 functions downstream of CEP350 to control biogenesis of primary cilia by negatively regulating CP110 levels.
    Title: CEP78 functions downstream of CEP350 to control biogenesis of primary cilia by negatively regulating CP110 levels.
  4. Myeloid/lymphoid neoplasm with CEP110-FGFR1 fusion: An analysis of 16 cases show common features and poor prognosis.
    Title: Myeloid/lymphoid neoplasm with CEP110-FGFR1 fusion: An analysis of 16 cases show common features and poor prognosis.
  5. PLK4 specifically phosphorylates CP110 at the S98 position and is an essential step for centriole assembly.
    Title: PLK4 phosphorylation of CP110 is required for efficient centriole assembly.
  6. This brief communication reports on a patient with an exceedingly rare "8p11 (eight-p-eleven) myeloproliferative syndrome" (EMS) with CEP110-FGFR1 rearrangement who responded to treatment with the multi-tyrosine kinase inhibitor (TKI) dasatinib
    Title: Response to Tyrosine Kinase Inhibitors in Myeloproliferative Neoplasia with 8p11 Translocation and CEP110-FGFR1 Rearrangement.
  7. In tissues of prostate cancer patients, low CP110 and high miR-129-3p expression levels correlated with metastasi
    Title: miR-129-3p controls centrosome number in metastatic prostate cancer cells by repressing CP110.
  8. We demonstrated that restoration of CP110 expression in MDA-MB-231 and MCF-7 cells by miR-129 overexpression rendered the cells sensitive to docetaxel.
    Title: MiR-129-3p promotes docetaxel resistance of breast cancer cells via CP110 inhibition.
  9. Data show thata combining cyclin-dependent kinase 2 (CDK2) antagonism and ubiquitin thioesterase 33 (USP33) depletion augments anaphase catastrophe via changes in centrosomal protein of 110 kDa (CP110) protein expression.
    Title: Specific CP110 Phosphorylation Sites Mediate Anaphase Catastrophe after CDK2 Inhibition: Evidence for Cooperation with USP33 Knockdown.
  10. CP110 plays a mechanistic role in response of lung cancer cells to CDK2 inhibition, especially in the presence of activated KRAS mutations.
    Title: CDK2 Inhibition Causes Anaphase Catastrophe in Lung Cancer through the Centrosomal Protein CP110.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0419, DKFZp781G1416

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in centriole replication IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in centriole replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in centrosome duplication IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in centrosome duplication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ciliary basal body organization IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in ciliary basal body organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of centriole elongation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in negative regulation of cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in centriole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
centriolar coiled-coil protein of 110 kDa
Names
centriolar coiled-coil protein 110kDa
centrosomal protein CP110
centrosomal protein of 110 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199022.3 → NP_001185951.2  centriolar coiled-coil protein of 110 kDa isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC012621, BC036654, BQ632514, BY798911, CN307903, CN307908, CR749255, DA250590
    Consensus CDS
    CCDS55992.1
    UniProtKB/Swiss-Prot
    O43303, Q8NE13
    Related
    ENSP00000370803.5, ENST00000381396.9
    Conserved Domains (1) summary
    pfam16025
    Location:29 → 125
    CALM_bind; Calcium-dependent calmodulin binding

  2. NM_001323569.2 → NP_001310498.1  centriolar coiled-coil protein of 110 kDa isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC012621
    Consensus CDS
    CCDS55992.1
    UniProtKB/Swiss-Prot
    O43303, Q8NE13
    Conserved Domains (1) summary
    pfam16025
    Location:29 → 125
    CALM_bind; Calcium-dependent calmodulin binding

  3. NM_001323570.2 → NP_001310499.1  centriolar coiled-coil protein of 110 kDa isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC012621
    Consensus CDS
    CCDS10579.1
    UniProtKB/Swiss-Prot
    O43303

  4. NM_001323571.2 → NP_001310500.1  centriolar coiled-coil protein of 110 kDa isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC012621
    Consensus CDS
    CCDS10579.1
    UniProtKB/Swiss-Prot
    O43303

  5. NM_001323572.2 → NP_001310501.1  centriolar coiled-coil protein of 110 kDa isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC012621
    Consensus CDS
    CCDS10579.1
    UniProtKB/Swiss-Prot
    O43303
    Related
    ENSP00000511625.1, ENST00000694978.1

  6. NM_001323576.2 → NP_001310505.1  centriolar coiled-coil protein of 110 kDa isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC012621
    Conserved Domains (1) summary
    pfam16025
    Location:29 → 125
    CALM_bind; Calcium-dependent calmodulin binding

  7. NM_001323577.2 → NP_001310506.1  centriolar coiled-coil protein of 110 kDa isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC012621
    Conserved Domains (1) summary
    pfam16025
    Location:29 → 125
    CALM_bind; Calcium-dependent calmodulin binding

  8. NM_014711.6 → NP_055526.4  centriolar coiled-coil protein of 110 kDa isoform 2

    Status: VALIDATED

    Source sequence(s)
    AB007879, AC012621, BC036654, BP360952, BY798911, CB066937, DA370828, DB504255
    Consensus CDS
    CCDS10579.1
    UniProtKB/Swiss-Prot
    O43303
    Related
    ENSP00000379515.2, ENST00000396212.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    19523942..19553408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023908.2 → XP_016879397.1  centriolar coiled-coil protein of 110 kDa isoform X1

    UniProtKB/Swiss-Prot
    O43303, Q8NE13
    Conserved Domains (1) summary
    pfam16025
    Location:29 → 125
    CALM_bind; Calcium-dependent calmodulin binding

  2. XM_011545991.3 → XP_011544293.1  centriolar coiled-coil protein of 110 kDa isoform X1

    See identical proteins and their annotated locations for XP_011544293.1

    UniProtKB/Swiss-Prot
    O43303, Q8NE13
    Conserved Domains (1) summary
    pfam16025
    Location:29 → 125
    CALM_bind; Calcium-dependent calmodulin binding

  3. XM_047434961.1 → XP_047290917.1  centriolar coiled-coil protein of 110 kDa isoform X2

  4. XM_011545992.3 → XP_011544294.1  centriolar coiled-coil protein of 110 kDa isoform X1

    See identical proteins and their annotated locations for XP_011544294.1

    UniProtKB/Swiss-Prot
    O43303, Q8NE13
    Conserved Domains (1) summary
    pfam16025
    Location:29 → 125
    CALM_bind; Calcium-dependent calmodulin binding

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    19454815..19484280
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054314502.1 → XP_054170477.1  centriolar coiled-coil protein of 110 kDa isoform X1

  2. XM_054314500.1 → XP_054170475.1  centriolar coiled-coil protein of 110 kDa isoform X1

  3. XM_054314503.1 → XP_054170478.1  centriolar coiled-coil protein of 110 kDa isoform X2

  4. XM_054314501.1 → XP_054170476.1  centriolar coiled-coil protein of 110 kDa isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O43303.3 GenPept UniProtKB/Swiss-Prot:O43303

Gene LinkOut

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