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Ccp110 centriolar coiled coil protein 110 [ Mus musculus (house mouse) ]

Gene ID: 101565, updated on 27-Nov-2024

Summary

Official Symbol
Ccp110provided by MGI
Official Full Name
centriolar coiled coil protein 110provided by MGI
Primary source
MGI:MGI:2141942
See related
Ensembl:ENSMUSG00000033904 AllianceGenome:MGI:2141942
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CP110; cep110; 6330503K22Rik
Summary
Involved in ciliary basal body organization; negative regulation of cilium assembly; and positive regulation of cilium assembly. Located in centriole and centrosome. Is expressed in several structures, including cerebral cortex; inner cell mass; and olfactory epithelium. Orthologous to human CCP110 (centriolar coiled-coil protein 110). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis adult (RPKM 18.6), CNS E11.5 (RPKM 17.0) and 16 other tissues See more
Orthologs
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Genomic context

See Ccp110 in Genome Data Viewer
Location:
7 F2; 7 63.58 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (118311740..118336247)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (118712515..118737024)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene transmembrane channel-like gene family 5 Neighboring gene STARR-positive B cell enhancer mm9_chr7:125849164-125849465 Neighboring gene STARR-positive B cell enhancer ABC_E4970 Neighboring gene glycerophosphodiester phosphodiesterase 1 Neighboring gene STARR-positive B cell enhancer ABC_E4971 Neighboring gene STARR-positive B cell enhancer ABC_E1359 Neighboring gene VPS35 endosomal protein sorting factor like Neighboring gene STARR-positive B cell enhancer mm9_chr7:125909648-125909949 Neighboring gene STARR-seq mESC enhancer starr_20020 Neighboring gene predicted gene, 26147 Neighboring gene lysine rich nucleolar protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in centriole replication IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in centriole replication IEA
Inferred from Electronic Annotation
more info
 
involved_in centriole replication ISO
Inferred from Sequence Orthology
more info
 
involved_in centrosome duplication ISO
Inferred from Sequence Orthology
more info
 
involved_in centrosome duplication ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in ciliary basal body organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ciliary basal body organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cilium assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cytokinesis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in centriole IDA
Inferred from Direct Assay
more info
PubMed 
located_in centriole ISO
Inferred from Sequence Orthology
more info
 
located_in centriole ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule organizing center IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
centriolar coiled-coil protein of 110 kDa
Names
centrosomal protein CP110
centrosomal protein of 110 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360793.1NP_001347722.1  centriolar coiled-coil protein of 110 kDa isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC152412, DV662471
    Conserved Domains (1) summary
    pfam16025
    Location:31106
    CALM_bind; Calcium-dependent calmodulin binding
  2. NM_001360794.1NP_001347723.1  centriolar coiled-coil protein of 110 kDa isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC152412, DV662471
    UniProtKB/TrEMBL
    A0A140LJ44
    Related
    ENSMUSP00000147070.2, ENSMUST00000123178.8
    Conserved Domains (1) summary
    pfam16025
    Location:31106
    CALM_bind; Calcium-dependent calmodulin binding
  3. NM_182995.2NP_892040.1  centriolar coiled-coil protein of 110 kDa isoform 1

    See identical proteins and their annotated locations for NP_892040.1

    Status: VALIDATED

    Source sequence(s)
    AC152412, BC053103, DV662471
    Consensus CDS
    CCDS21775.1
    UniProtKB/Swiss-Prot
    Q6A072, Q7TSH4
    Related
    ENSMUSP00000102167.2, ENSMUST00000106557.8
    Conserved Domains (1) summary
    pfam16025
    Location:29131
    CALM_bind; Calcium-dependent calmodulin binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    118311740..118336247
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321910.2XP_017177399.1  centriolar coiled-coil protein of 110 kDa isoform X1

    UniProtKB/TrEMBL
    A0A140LJ44
    Conserved Domains (1) summary
    pfam16025
    Location:31106
    CALM_bind; Calcium-dependent calmodulin binding
  2. XM_006507159.4XP_006507222.1  centriolar coiled-coil protein of 110 kDa isoform X2

    UniProtKB/TrEMBL
    A0A140LJ44
    Conserved Domains (1) summary
    pfam16025
    Location:31106
    CALM_bind; Calcium-dependent calmodulin binding