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HDAC9 histone deacetylase 9 [ Homo sapiens (human) ]

Gene ID: 9734, updated on 15-Jun-2019

Summary

Official Symbol
HDAC9provided by HGNC
Official Full Name
histone deacetylase 9provided by HGNC
Primary source
HGNC:HGNC:14065
See related
Ensembl:ENSG00000048052 MIM:606543
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HD7; HD9; HD7b; HDAC; HDRP; MITR; HDAC7; HDAC7B; HDAC9B; HDAC9FL
Summary
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 2.1), brain (RPKM 2.0) and 24 other tissues See more
Orthologs

Genomic context

See HDAC9 in Genome Data Viewer
Location:
7p21.1
Exon count:
38
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (18086942..19002416)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (18126572..19039135)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene RNA methyltransferase like 1 pseudogene 2 Neighboring gene phosphoribosyl pyrophosphate synthetase 1 like 1 Neighboring gene microRNA 1302-6 Neighboring gene GATA motif-containing MPRA enhancer 275 Neighboring gene uncharacterized LOC107986698 Neighboring gene casein kinase 1 alpha 1 pseudogene Neighboring gene eExon 18 TWIST1 limb enhancer Neighboring gene eExon 19 TWIST1 limb enhancer Neighboring gene VISTA enhancer hs644 Neighboring gene RN7SK pseudogene 266 Neighboring gene uncharacterized LOC105375176 Neighboring gene nucleophosmin 1 pseudogene 13 Neighboring gene twist family bHLH transcription factor 1 Neighboring gene Fer3 like bHLH transcription factor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic predictors of medically refractory ulcerative colitis.
NHGRI GWA Catalog
Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies.
NHGRI GWA Catalog
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
NHGRI GWA Catalog
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke.
NHGRI GWA Catalog
Genome-Wide Association Study of Intracranial Aneurysm Identifies a New Association on Chromosome 7.
NHGRI GWA Catalog
Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384.
NHGRI GWA Catalog
Genome-wide association study of retinopathy in individuals without diabetes.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
NHGRI GWA Catalog
Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases.
NHGRI GWA Catalog

Pathways from BioSystems

  • Alcoholism, organism-specific biosystem (from KEGG)
    Alcoholism, organism-specific biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
  • Alcoholism, conserved biosystem (from KEGG)
    Alcoholism, conserved biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
  • Cardiac Hypertrophic Response, organism-specific biosystem (from WikiPathways)
    Cardiac Hypertrophic Response, organism-specific biosystemIntegrated schematic of the more extensively characterized intracellular signal-transduction pathways that coordinate the cardiac hypertrophic response. During development and in response to physiolo...
  • Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, organism-specific biosystem (from REACTOME)
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, organism-specific biosystemWhen found in cis, HD and PEST domain mutations act synergistically, increasing NOTCH1 transcriptional activity up to ~40-fold, compared with up to ~10-fold and up to ~2-fold increase with HD mutatio...
  • Constitutive Signaling by NOTCH1 PEST Domain Mutants, organism-specific biosystem (from REACTOME)
    Constitutive Signaling by NOTCH1 PEST Domain Mutants, organism-specific biosystemAs NOTCH1 PEST domain is intracellular, NOTCH1 PEST domain mutants are expected to behave as the wild-type NOTCH1 with respect to ligand binding and proteolytic cleavage mediated activation of signal...
  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • Diseases of signal transduction, organism-specific biosystem (from REACTOME)
    Diseases of signal transduction, organism-specific biosystemSignaling processes are central to human physiology (e.g., Pires-da Silva & Sommer 2003), and their disruption by either germ-line and somatic mutation can lead to serious disease. Here, the molecula...
  • Initiation of transcription and translation elongation at the HIV-1 LTR, organism-specific biosystem (from WikiPathways)
    Initiation of transcription and translation elongation at the HIV-1 LTR, organism-specific biosystemFollowing cellular activation or drug treatment, NFAT and NF-kB translocate to the nucleus and bind sites at the HIV-1 LTR. NFAT and NF-kB recruit p300/CBP to the LTR, resulting in acetylation of his...
  • MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem (from WikiPathways)
    MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystemThis pathway shows the role of microRNAs in the process of cardiac hypertrophy. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted interactions are shown in red dashed lin...
  • NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystem (from REACTOME)
    NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystemNICD1 produced by activation of NOTCH1 in response to Delta and Jagged ligands (DLL/JAG) presented in trans, traffics to the nucleus where it acts as a transcription regulator. In the nucleus, NICD1 ...
  • Neural Crest Differentiation, organism-specific biosystem (from WikiPathways)
    Neural Crest Differentiation, organism-specific biosystemGene regulatory network model of cranial neural crest cell (CNCC) development, adaped from PMID: 19575671. Most interactions in the model are proposed to regulate transcription of core factors involv...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by NOTCH, organism-specific biosystem (from REACTOME)
    Signaling by NOTCH, organism-specific biosystemThe Notch Signaling Pathway (NSP) is a highly conserved pathway for cell-cell communication. NSP is involved in the regulation of cellular differentiation, proliferation, and specification. For exam...
  • Signaling by NOTCH1, organism-specific biosystem (from REACTOME)
    Signaling by NOTCH1, organism-specific biosystemNOTCH1 functions as both a transmembrane receptor presented on the cell surface and as a transcriptional regulator in the nucleus.NOTCH1 receptor presented on the plasma membrane is activated by a me...
  • Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, organism-specific biosystem (from REACTOME)
    Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, organism-specific biosystemMutations in the heterodimerization domain (HD) and PEST domain of NOTCH1 are frequently found in cis in T-cell acute lymphoblastic leukemia. While HD mutations alone result in up to ~10-fold increas...
  • Signaling by NOTCH1 PEST Domain Mutants in Cancer, organism-specific biosystem (from REACTOME)
    Signaling by NOTCH1 PEST Domain Mutants in Cancer, organism-specific biosystemNOTCH1 PEST domain mutations are frequently found in T-cell acute lymphoblastic leukemia (T-ALL). PEST domain mutations interfere with ubiquitination-mediated NOTCH1 downregulation and result in prol...
  • Signaling by NOTCH1 in Cancer, organism-specific biosystem (from REACTOME)
    Signaling by NOTCH1 in Cancer, organism-specific biosystemHuman NOTCH1 was cloned as a chromosome 9 gene, translocated to the T-cell beta receptor (TCBR) promoter on chromosome 7 in T-cell acute lymphoblastic leukemia (T-ALL) (Ellisen et al. 1991). This tra...
  • Signaling events mediated by HDAC Class I, organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by HDAC Class I, organism-specific biosystem
    Signaling events mediated by HDAC Class I
  • Signaling events mediated by HDAC Class II, organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by HDAC Class II, organism-specific biosystem
    Signaling events mediated by HDAC Class II
  • Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
    Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
  • Viral carcinogenesis, organism-specific biosystem (from KEGG)
    Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
  • Viral carcinogenesis, conserved biosystem (from KEGG)
    Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0744, DKFZp779K1053

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NAD-dependent histone deacetylase activity (H3-K14 specific) IEA
Inferred from Electronic Annotation
more info
 
histone deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
histone deacetylase activity (H4-K16 specific) IDA
Inferred from Direct Assay
more info
PubMed 
histone deacetylase binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase C binding IPI
Inferred from Physical Interaction
more info
PubMed 
repressing transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
repressing transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
repressing transcription factor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription corepressor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
B cell activation TAS
Traceable Author Statement
more info
PubMed 
B cell differentiation TAS
Traceable Author Statement
more info
PubMed 
cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cholesterol homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
heart development ISS
Inferred from Sequence or Structural Similarity
more info
 
histone H3 deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H4 deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H4-K16 deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cytokine secretion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of lipoprotein lipase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-lysine deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of skeletal muscle fiber development ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of striated muscle cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
response to amphetamine IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
histone deacetylase complex TAS
Traceable Author Statement
more info
PubMed 
histone methyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone deacetylase 9
Names
MEF-2 interacting transcription repressor (MITR) protein
histone deacetylase 4/5-related protein
histone deacetylase 7B
NP_001191073.1
NP_001191074.1
NP_001191075.1
NP_001191076.1
NP_001191077.1
NP_001308797.1
NP_001308798.1
NP_001308799.1
NP_001308800.1
NP_001308801.1
NP_001308802.1
NP_001308803.1
NP_001308804.1
NP_001308805.1
NP_001308806.1
NP_001308807.1
NP_001308808.1
NP_001308813.1
NP_001308814.1
NP_001308815.1
NP_001308816.1
NP_001308817.1
NP_001308818.1
NP_001308819.1
NP_001308820.1
NP_001308822.1
NP_001308823.1
NP_001308824.1
NP_001308825.1
NP_001308826.1
NP_001308827.1
NP_001308828.1
NP_001308829.1
NP_001308830.1
NP_001308831.1
NP_055522.1
NP_478056.1
NP_848510.1
NP_848512.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023250.3 RefSeqGene

    Range
    413762..920468
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001204144.3NP_001191073.1  histone deacetylase 9 isoform 6

    See identical proteins and their annotated locations for NP_001191073.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence, the 3' UTR and coding sequence, and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (6) is longer at the N-terminus, has a shorter and distinct C-terminus, and lacks an internal segment compared to isoform 1.
    Source sequence(s)
    AC074193, AK304298, BC150328, DC333353
    Consensus CDS
    CCDS56465.1
    UniProtKB/Swiss-Prot
    Q9UKV0
    Related
    ENSP00000401669.2, ENST00000417496.6
    Conserved Domains (1) summary
    cl25407
    Location:80166
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
  2. NM_001204145.3NP_001191074.1  histone deacetylase 9 isoform 7

    See identical proteins and their annotated locations for NP_001191074.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has an extended 5' UTR, differs in the 3' UTR and coding sequence, and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (7) has a shorter and distinct C-terminus and lacks an internal segment compared to isoform 1. Variants 7, 30 and 31 encode the same isoform (7).
    Source sequence(s)
    AC002433, AK297404, BC150328, DC333611
    Consensus CDS
    CCDS56466.1
    UniProtKB/Swiss-Prot
    Q9UKV0
    Related
    ENSP00000395655.2, ENST00000428307.6
    Conserved Domains (1) summary
    cl25407
    Location:38124
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
  3. NM_001204146.2NP_001191075.1  histone deacetylase 9 isoform 8

    See identical proteins and their annotated locations for NP_001191075.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) has an extended 5' UTR, differs in the 3' UTR and coding sequence, lacks an alternate in-frame exon, and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (8) has a shorter and distinct C-terminus, lacks an internal segment, and contains an alternate short internal segment compared to isoform 1.
    Source sequence(s)
    AC002433, AK316109, BC150328, DC333611
    Consensus CDS
    CCDS75565.1
    UniProtKB/Swiss-Prot
    Q9UKV0
    UniProtKB/TrEMBL
    B7Z3P7
    Related
    ENSP00000478829.1, ENST00000622668.4
    Conserved Domains (1) summary
    cd10163
    Location:38127
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
  4. NM_001204147.3NP_001191076.1  histone deacetylase 9 isoform 9

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR and coding sequence, the 3' UTR and coding sequence, and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (9) is shorter at the N-terminus, has a shorter and distinct C-terminus, and lacks an internal segment compared to isoform 1.
    Source sequence(s)
    AC002433, AK304343, AK304410, BC150328, DC369899
    Consensus CDS
    CCDS56468.1
    UniProtKB/Swiss-Prot
    Q9UKV0
    Related
    ENSP00000430036.1, ENST00000524023.1
    Conserved Domains (1) summary
    cl25407
    Location:793
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
  5. NM_001204148.3NP_001191077.1  histone deacetylase 9 isoform 10

    See identical proteins and their annotated locations for NP_001191077.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR and coding sequence, the 3' UTR and coding sequence, and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (10) is shorter at the N-terminus, has a shorter and distinct C-terminus, and contains an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AC002124, AC002433, AK304343, AK304410, BC150328, DC369899
    Consensus CDS
    CCDS56467.1
    UniProtKB/Swiss-Prot
    Q9UKV0
    Related
    ENSP00000388568.2, ENST00000456174.6
    Conserved Domains (1) summary
    cd10163
    Location:796
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
  6. NM_001321868.2NP_001308797.1  histone deacetylase 9 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC004744, AC074193, AJ459808, AK304298, BQ575888, DC333353
    UniProtKB/Swiss-Prot
    Q9UKV0
    Conserved Domains (2) summary
    cd10163
    Location:60146
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
    cd11681
    Location:609986
    HDAC_classIIa; Histone deacetylases, class IIa
  7. NM_001321869.2NP_001308798.1  histone deacetylase 9 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC074193, AJ459808, AK304298, AK316109, BC150328, DC333353
    UniProtKB/Swiss-Prot
    Q9UKV0
    UniProtKB/TrEMBL
    B7Z3P7
    Conserved Domains (1) summary
    cd10163
    Location:60149
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
  8. NM_001321870.2NP_001308799.1  histone deacetylase 9 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC074193, AJ459808, AK304298, AK316109, BC150328, DC333353
    UniProtKB/Swiss-Prot
    Q9UKV0
    UniProtKB/TrEMBL
    B7Z3P7
    Conserved Domains (1) summary
    cl25407
    Location:60146
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
  9. NM_001321871.2NP_001308800.1  histone deacetylase 9 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC002433, AC074193, AK304298, BC150328, DC333353
    UniProtKB/Swiss-Prot
    Q9UKV0
    Conserved Domains (1) summary
    cl25407
    Location:60146
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
  10. NM_001321872.2NP_001308801.1  histone deacetylase 9 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC074193, AJ459808, AK304298, AK316109, BC150328, DC333353
    UniProtKB/Swiss-Prot
    Q9UKV0
    UniProtKB/TrEMBL
    B7Z3P7
    Conserved Domains (1) summary
    cd10163
    Location:60149
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
  11. NM_001321873.2NP_001308802.1  histone deacetylase 9 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC074193, AK304298, AK316109, BC150328, DC333353
    UniProtKB/Swiss-Prot
    Q9UKV0
    UniProtKB/TrEMBL
    B7Z3P7
    Conserved Domains (1) summary
    cd10163
    Location:60149
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
  12. NM_001321874.2NP_001308803.1  histone deacetylase 9 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328, DC333611
    UniProtKB/Swiss-Prot
    Q9UKV0
    Conserved Domains (1) summary
    cd10163
    Location:38127
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
  13. NM_001321875.2NP_001308804.1  histone deacetylase 9 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328, DC333611
    UniProtKB/Swiss-Prot
    Q9UKV0
    Conserved Domains (1) summary
    cl25407
    Location:38124
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
  14. NM_001321876.2NP_001308805.1  histone deacetylase 9 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328, DC333611
    UniProtKB/Swiss-Prot
    Q9UKV0
    Conserved Domains (1) summary
    cd10163
    Location:38127
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
  15. NM_001321877.2NP_001308806.1  histone deacetylase 9 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC002088, AC002124, AC002410, AC002433, AC004744, AC004994, BQ575888, DC333611
    Consensus CDS
    CCDS83163.1
    UniProtKB/Swiss-Prot
    Q9UKV0
    Related
    ENSP00000383912.1, ENST00000401921.5
    Conserved Domains (2) summary
    cd10163
    Location:38127
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
    cd11681
    Location:590967
    HDAC_classIIa; Histone deacetylases, class IIa
  16. NM_001321878.2NP_001308807.1  histone deacetylase 9 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328, DC333611
    UniProtKB/Swiss-Prot
    Q9UKV0
    Conserved Domains (1) summary
    cl23765
    Location:38124
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
  17. NM_001321879.2NP_001308808.1  histone deacetylase 9 isoform 22

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328, DC333611
    UniProtKB/Swiss-Prot
    Q9UKV0
    Conserved Domains (1) summary
    cd10163
    Location:38127
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
  18. NM_001321884.2NP_001308813.1  histone deacetylase 9 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328, DC333611
    UniProtKB/Swiss-Prot
    Q9UKV0
    Conserved Domains (1) summary
    cd10163
    Location:38127
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
  19. NM_001321885.2NP_001308814.1  histone deacetylase 9 isoform 24

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328, DC333611
    UniProtKB/Swiss-Prot
    Q9UKV0
    Conserved Domains (1) summary
    cd10163
    Location:38127
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
  20. NM_001321886.2NP_001308815.1  histone deacetylase 9 isoform 25

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328, DC333611
    UniProtKB/Swiss-Prot
    Q9UKV0
    Conserved Domains (1) summary
    cl23765
    Location:793
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
  21. NM_001321887.2NP_001308816.1  histone deacetylase 9 isoform 26

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328
    UniProtKB/Swiss-Prot
    Q9UKV0
    Conserved Domains (1) summary
    cd10163
    Location:796
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
  22. NM_001321888.2NP_001308817.1  histone deacetylase 9 isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328
    UniProtKB/Swiss-Prot
    Q9UKV0
    Conserved Domains (1) summary
    cl25407
    Location:38124
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
  23. NM_001321889.2NP_001308818.1  histone deacetylase 9 isoform 28

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328, DC333611
    UniProtKB/Swiss-Prot
    Q9UKV0
    Conserved Domains (1) summary
    cd10163
    Location:796
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
  24. NM_001321890.2NP_001308819.1  histone deacetylase 9 isoform 29

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328, DC333611
    UniProtKB/Swiss-Prot
    Q9UKV0
    Conserved Domains (1) summary
    cl25407
    Location:38124
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
  25. NM_001321891.2NP_001308820.1  histone deacetylase 9 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328, DC333611
    Consensus CDS
    CCDS56466.1
    UniProtKB/Swiss-Prot
    Q9UKV0
    Conserved Domains (1) summary
    cl25407
    Location:38124
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
  26. NM_001321893.2NP_001308822.1  histone deacetylase 9 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328
    Consensus CDS
    CCDS56466.1
    UniProtKB/Swiss-Prot
    Q9UKV0
    Conserved Domains (1) summary
    cl25407
    Location:38124
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
  27. NM_001321894.2NP_001308823.1  histone deacetylase 9 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328, DC333611
    Consensus CDS
    CCDS75565.1
    UniProtKB/Swiss-Prot
    Q9UKV0
    UniProtKB/TrEMBL
    B7Z3P7
    Conserved Domains (1) summary
    cd10163
    Location:38127
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
  28. NM_001321895.2NP_001308824.1  histone deacetylase 9 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328, DC333611
    Consensus CDS
    CCDS75565.1
    UniProtKB/Swiss-Prot
    Q9UKV0
    UniProtKB/TrEMBL
    B7Z3P7
    Related
    ENSP00000384017.1, ENST00000406072.5
    Conserved Domains (1) summary
    cd10163
    Location:38127
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
  29. NM_001321896.1NP_001308825.1  histone deacetylase 9 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, AC091697, BC150328, CD701953
    Consensus CDS
    CCDS56467.1
    UniProtKB/Swiss-Prot
    Q9UKV0
    Conserved Domains (1) summary
    cd10163
    Location:796
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
  30. NM_001321897.2NP_001308826.1  histone deacetylase 9 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC002088, AC002124, AC002410, AC002433, AC004744, AC004994, BQ575888, DC333611
    Consensus CDS
    CCDS83163.1
    UniProtKB/Swiss-Prot
    Q9UKV0
    Conserved Domains (2) summary
    cd10163
    Location:38127
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
    cd11681
    Location:590967
    HDAC_classIIa; Histone deacetylases, class IIa
  31. NM_001321898.2NP_001308827.1  histone deacetylase 9 isoform 24

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328
    UniProtKB/Swiss-Prot
    Q9UKV0
    Conserved Domains (1) summary
    cd10163
    Location:38127
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
  32. NM_001321899.2NP_001308828.1  histone deacetylase 9 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328
    UniProtKB/Swiss-Prot
    Q9UKV0
    Conserved Domains (1) summary
    cd10163
    Location:38127
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
  33. NM_001321900.2NP_001308829.1  histone deacetylase 9 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328, DC333611
    Consensus CDS
    CCDS47557.1
    UniProtKB/Swiss-Prot
    Q9UKV0
    Conserved Domains (1) summary
    cl25407
    Location:38124
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
  34. NM_001321901.2NP_001308830.1  histone deacetylase 9 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328
    UniProtKB/Swiss-Prot
    Q9UKV0
    Conserved Domains (1) summary
    cd10163
    Location:38127
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
  35. NM_001321902.2NP_001308831.1  histone deacetylase 9 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC002124, AC002433, BC150328, DC333611
    UniProtKB/Swiss-Prot
    Q9UKV0
    Conserved Domains (1) summary
    cd10163
    Location:38127
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
  36. NM_014707.4NP_055522.1  histone deacetylase 9 isoform 3

    See identical proteins and their annotated locations for NP_055522.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks multiple 3' exons and has an alternate 3' segment including the coding region and UTR, compared to variant 1. The resulting isoform 3, also known as HDRP, has a much shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC152405
    Consensus CDS
    CCDS47557.1
    UniProtKB/Swiss-Prot
    Q9UKV0
    Related
    ENSP00000384382.3, ENST00000405010.7
    Conserved Domains (1) summary
    cl25407
    Location:38124
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
  37. NM_058176.2NP_478056.1  histone deacetylase 9 isoform 1

    See identical proteins and their annotated locations for NP_478056.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the predominant isoform (1).
    Source sequence(s)
    AA405905, AY032737, BC152405
    Consensus CDS
    CCDS47555.1
    UniProtKB/Swiss-Prot
    Q9UKV0
    Related
    ENSP00000410337.2, ENST00000432645.6
    Conserved Domains (2) summary
    cd10163
    Location:38124
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
    cd10009
    Location:6311009
    HDAC9; Histone deacetylase 9
  38. NM_178423.3NP_848510.1  histone deacetylase 9 isoform 4

    See identical proteins and their annotated locations for NP_848510.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an alternate 3' sequence including the coding region and UTR, compared to variant 1. The resulting isoform 4, also known as HDAC9fl, has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC004744, AJ459808, BQ575888
    Consensus CDS
    CCDS47554.1
    UniProtKB/Swiss-Prot
    Q9UKV0
    Related
    ENSP00000384657.3, ENST00000406451.8
    Conserved Domains (2) summary
    cd10163
    Location:38124
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
    cd11681
    Location:6311008
    HDAC_classIIa; Histone deacetylases, class IIa
  39. NM_178425.3NP_848512.1  histone deacetylase 9 isoform 5

    See identical proteins and their annotated locations for NP_848512.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has an alternate 3' sequence including the coding region and UTR, compared to variant 1. The resulting isoform 5 has a distinct C-terminus, compared to isoform 1. This variant is incomplete at the 5' end.
    Source sequence(s)
    AC004744, AJ459808, AY197371, BC152405, BQ575888
    Consensus CDS
    CCDS47553.1
    UniProtKB/Swiss-Prot
    Q9UKV0
    Related
    ENSP00000408617.2, ENST00000441542.6
    Conserved Domains (2) summary
    cd10163
    Location:38127
    ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
    cd11681
    Location:6341011
    HDAC_classIIa; Histone deacetylases, class IIa

RNA

  1. NR_135835.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC002433, BC092441, DC333611

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    18086825..19002416
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_058177.2: Suppressed sequence

    Description
    NM_058177.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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