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SART3 spliceosome associated factor 3, U4/U6 recycling protein [ Homo sapiens (human) ]

Gene ID: 9733, updated on 5-May-2024

Summary

Official Symbol
SART3provided by HGNC
Official Full Name
spliceosome associated factor 3, U4/U6 recycling proteinprovided by HGNC
Primary source
HGNC:HGNC:16860
See related
Ensembl:ENSG00000075856 MIM:611684; AllianceGenome:HGNC:16860
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P100; p110; DSAP1; TIP110; p110(nrb); RP11-13G14
Summary
The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 12.7), lymph node (RPKM 12.3) and 25 other tissues See more
Orthologs
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Genomic context

See SART3 in Genome Data Viewer
Location:
12q23.3
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (108522214..108561173, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (108491579..108530540, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (108915991..108954949, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1498 Neighboring gene MPRA-validated peak1935 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr12:108906844-108907029 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6960 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:108910488-108910988 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:108910989-108911489 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:108918373-108919572 Neighboring gene FIC domain protein adenylyltransferase Neighboring gene MPRA-validated peak1936 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6962 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4827 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6963 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6965 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6966 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4828 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6967 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4829 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6969 Neighboring gene iron-sulfur cluster assembly enzyme Neighboring gene ReSE screen-validated silencer GRCh37_chr12:108976096-108976273 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:108982554-108983282 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:108987423-108988089 Neighboring gene transmembrane protein 119

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat complexes with LARP7, MEPCE, SART3, NPM1, PPM1G, hnRNP-F, and 7SK RNA to form a Tat-7SK RNP complex to control HIV-1 transcription PubMed
tat The interaction of Tip110 with HIV-1 Tat leads to a higher efficiency of elongation for RNAPII complexes formed on the LTR promoter PubMed
tat Expression of both Tip110 and Tat enhances phosphorylation of RNAPII at both serine 2 and serine 5, which account for Tip110 function in transcription activation PubMed
tat The interaction of Tip110 with HIV-1 Tat and the RNAPII C-terminal domain leads to the recruitment of increased CDK9/CycT1 to the transcription complex PubMed
tat Tip110 binds to HIV-1 Tat and regulates Tat transactivation activity, suggesting an important role for Tip110 in HIV-1 gene expression and viral replication PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0156, MGC138188

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
NOT enables U4 snRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables U4 snRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables U6 snRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables U6atac snRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin-specific protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of ASAP complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Cajal body IDA
Inferred from Direct Assay
more info
PubMed 
part_of U4/U6 snRNP IDA
Inferred from Direct Assay
more info
PubMed 
NOT part_of U4/U6 x U5 tri-snRNP complex IDA
Inferred from Direct Assay
more info
PubMed 
NOT part_of U4atac/U6atac snRNP IDA
Inferred from Direct Assay
more info
PubMed 
part_of U6atac snRNP IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
squamous cell carcinoma antigen recognized by T-cells 3
Names
HIV-1 Tat-interacting protein of 110kDa
PRP24 homolog
SART-3
hSART-3
p110 nuclear RNA-binding protein
squamous cell carcinoma antigen recognized by T cells 3
tat-interacting protein of 110 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012155.2 RefSeqGene

    Range
    5217..44176
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1285

mRNA and Protein(s)

  1. NM_001410983.1NP_001397912.1  squamous cell carcinoma antigen recognized by T-cells 3 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC008119, AC010206
    Consensus CDS
    CCDS91747.1
    UniProtKB/TrEMBL
    A0A499FI31
    Related
    ENSP00000228284.4, ENST00000228284.8
  2. NM_014706.4NP_055521.1  squamous cell carcinoma antigen recognized by T-cells 3 isoform 1

    See identical proteins and their annotated locations for NP_055521.1

    Status: REVIEWED

    Source sequence(s)
    AI656011, BC032601, BQ231651, CN349201, D63879, DA391623
    Consensus CDS
    CCDS9117.1
    UniProtKB/Swiss-Prot
    A8K2E4, B7ZKM0, Q15020, Q2M2H0, Q58F06, Q8IUS1, Q96J95
    Related
    ENSP00000449386.2, ENST00000546815.6
    Conserved Domains (4) summary
    cd12391
    Location:705778
    RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
    cd12392
    Location:799879
    RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
    pfam16605
    Location:877933
    LSM_int_assoc; LSM-interacting associated unstructured
    cl26993
    Location:100460
    Suf; Suppressor of forked protein (Suf)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    108522214..108561173 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047429916.1XP_047285872.1  squamous cell carcinoma antigen recognized by T-cells 3 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    108491579..108530540 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054373894.1XP_054229869.1  squamous cell carcinoma antigen recognized by T-cells 3 isoform X1