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SART3 squamous cell carcinoma antigen recognized by T cells 3 [ Homo sapiens (human) ]

Gene ID: 9733, updated on 21-Dec-2017
Official Symbol
SART3provided by HGNC
Official Full Name
squamous cell carcinoma antigen recognized by T cells 3provided by HGNC
Primary source
HGNC:HGNC:16860
See related
Ensembl:ENSG00000075856 MIM:611684; Vega:OTTHUMG00000169449
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P100; p110; DSAP1; TIP110; p110(nrb); RP11-13G14
Summary
The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 12.7), lymph node (RPKM 12.3) and 25 other tissues See more
Orthologs
Location:
12q23.3
Exon count:
20
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 12 NC_000012.12 (108522214..108561402, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (108915991..108955165, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1498 Neighboring gene FIC domain containing Neighboring gene iron-sulfur cluster assembly enzyme Neighboring gene transmembrane protein 119

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat complexes with LARP7, MEPCE, SART3, NPM1, PPM1G, hnRNP-F, and 7SK RNA to form a Tat-7SK RNP complex to control HIV-1 transcription PubMed
tat The interaction of Tip110 with HIV-1 Tat leads to a higher efficiency of elongation for RNAPII complexes formed on the LTR promoter PubMed
tat Expression of both Tip110 and Tat enhances phosphorylation of RNAPII at both serine 2 and serine 5, which account for Tip110 function in transcription activation PubMed
tat The interaction of Tip110 with HIV-1 Tat and the RNAPII C-terminal domain leads to the recruitment of increased CDK9/CycT1 to the transcription complex PubMed
tat Tip110 binds to HIV-1 Tat and regulates Tat transactivation activity, suggesting an important role for Tip110 in HIV-1 gene expression and viral replication PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0156, MGC138188

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
U4 snRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
NOT U4 snRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
U6 snRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
U6atac snRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
histone binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-specific protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell morphogenesis IEA
Inferred from Electronic Annotation
more info
 
hematopoietic stem cell proliferation IEA
Inferred from Electronic Annotation
more info
 
homeostasis of number of cells IEA
Inferred from Electronic Annotation
more info
 
mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of histone deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
spliceosomal snRNP assembly IDA
Inferred from Direct Assay
more info
PubMed 
spliceosomal tri-snRNP complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Cajal body IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with U4/U6 snRNP IDA
Inferred from Direct Assay
more info
PubMed 
NOT colocalizes_with U4/U6 x U5 tri-snRNP complex IDA
Inferred from Direct Assay
more info
PubMed 
NOT colocalizes_with U4atac/U6atac snRNP IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with U6atac snRNP IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
squamous cell carcinoma antigen recognized by T-cells 3
Names
HIV-1 Tat-interacting protein of 110kDa
SART-3
hSART-3
p110 nuclear RNA-binding protein
tat-interacting protein of 110 kDa

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012155.1 RefSeqGene

    Range
    5001..44175
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_014706.3NP_055521.1  squamous cell carcinoma antigen recognized by T-cells 3

    See identical proteins and their annotated locations for NP_055521.1

    Status: REVIEWED

    Source sequence(s)
    AI656011, BC032601, BQ231651, CN349201, D63879, DA391623
    Consensus CDS
    CCDS9117.1
    UniProtKB/Swiss-Prot
    Q15020
    Related
    ENSP00000228284.3, OTTHUMP00000241139, ENST00000228284.7, OTTHUMT00000404094
    Conserved Domains (4) summary
    cd12391
    Location:705778
    RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
    cd12392
    Location:799879
    RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
    pfam16605
    Location:877933
    LSM_int_assoc; LSM-interacting associated unstructured
    cl26993
    Location:100460
    Suf; Suppressor of forked protein (Suf)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p7 Primary Assembly

    Range
    108522214..108561402 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005269241.4XP_005269298.1  squamous cell carcinoma antigen recognized by T-cells 3 isoform X1

    Conserved Domains (6) summary
    COG0724
    Location:654876
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    COG5107
    Location:100478
    RNA14; Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]
    cd12391
    Location:723796
    RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
    cd12392
    Location:817897
    RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
    pfam08424
    Location:351504
    NRDE-2; NRDE-2, necessary for RNA interference
    pfam16605
    Location:895951
    LSM_int_assoc; LSM-interacting associated unstructured
  2. XM_011539026.2XP_011537328.1  squamous cell carcinoma antigen recognized by T-cells 3 isoform X2

    Conserved Domains (5) summary
    COG0724
    Location:348570
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12391
    Location:417490
    RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
    cd12392
    Location:511591
    RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
    pfam08424
    Location:45198
    NRDE-2; NRDE-2, necessary for RNA interference
    pfam16605
    Location:589645
    LSM_int_assoc; LSM-interacting associated unstructured

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    108882205..108921384 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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