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AQR aquarius intron-binding spliceosomal factor [ Homo sapiens (human) ]

Gene ID: 9716, updated on 21-Dec-2019

Summary

Official Symbol
AQRprovided by HGNC
Official Full Name
aquarius intron-binding spliceosomal factorprovided by HGNC
Primary source
HGNC:HGNC:29513
See related
Ensembl:ENSG00000021776 MIM:610548
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IBP160; fSAP164
Expression
Ubiquitous expression in testis (RPKM 10.7), thyroid (RPKM 9.9) and 25 other tissues See more
Orthologs

Genomic context

See AQR in Genome Data Viewer
Location:
15q14
Exon count:
35
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (34851782..34969742, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (35148552..35261995, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928174 Neighboring gene uncharacterized LOC107984776 Neighboring gene tubulin alpha-1C chain-like Neighboring gene ribosomal protein L36a pseudogene 8 Neighboring gene uncharacterized LOC105370764 Neighboring gene zinc finger protein 770 Neighboring gene uncharacterized LOC105370763

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of aquarius homolog (AQR) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0560, DKFZp686B23123

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
mRNA splicing, via spliceosome IC
Inferred by Curator
more info
PubMed 
mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 
transcription-coupled nucleotide-excision repair TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
U2-type catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
RNA helicase aquarius
Names
aquarius homolog
functional spliceosome-associated protein 164
intron-binding protein aquarius
intron-binding protein of 160 kDa
NP_055506.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014691.3NP_055506.1  RNA helicase aquarius

    See identical proteins and their annotated locations for NP_055506.1

    Status: VALIDATED

    Source sequence(s)
    AC018868
    Consensus CDS
    CCDS42013.1
    UniProtKB/Swiss-Prot
    O60306
    UniProtKB/TrEMBL
    A0A024R9L1
    Related
    ENSP00000156471.5, ENST00000156471.10
    Conserved Domains (3) summary
    pfam16399
    Location:18802
    Aquarius_N; Intron-binding protein aquarius N-terminus
    cd18808
    Location:11401323
    SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
    cd17935
    Location:7971152
    EEXXQc_AQR; EEXXQ-box helicase domain of AQR

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    34851782..34969742 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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