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RIMS2 regulating synaptic membrane exocytosis 2 [ Homo sapiens (human) ]

Gene ID: 9699, updated on 22-May-2022

Summary

Official Symbol
RIMS2provided by HGNC
Official Full Name
regulating synaptic membrane exocytosis 2provided by HGNC
Primary source
HGNC:HGNC:17283
See related
Ensembl:ENSG00000176406 MIM:606630; AllianceGenome:HGNC:17283
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OBOE; RIM2; CRSDS; RAB3IP3
Summary
The protein encoded by this gene is a presynaptic protein that interacts with RAB3, a protein important for normal neurotransmitter release. The encoded protein can also bind several other synaptic proteins, including UNC-13 homolog B, ELKS/Rab6-interacting/CAST family member 1, and synaptotagmin 1. This protein is involved in synaptic membrane exocytosis. Polymorphisms in this gene have been associated with degenerative lumbar scoliosis. [provided by RefSeq, Feb 2017]
Expression
Biased expression in adrenal (RPKM 12.7), brain (RPKM 6.8) and 1 other tissue See more
Orthologs
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Genomic context

See RIMS2 in Genome Data Viewer
Location:
8q22.3
Exon count:
42
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (103500610..104256094)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (104628208..105383642)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (104512838..105268322)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 32 Neighboring gene uncharacterized LOC105375690 Neighboring gene DDB1 and CUL4 associated factor 13 Neighboring gene Sharpr-MPRA regulatory region 6081 Neighboring gene mediator complex subunit 21 pseudogene Neighboring gene prothymosin alpha pseudogene 15 Neighboring gene small nucleolar RNA U13 Neighboring gene Sharpr-MPRA regulatory region 13468 Neighboring gene TARBP2 pseudogene 1 Neighboring gene ribosomal protein S6 pseudogene 9 Neighboring gene uncharacterized LOC105375689 Neighboring gene Sharpr-MPRA regulatory region 520 Neighboring gene uncharacterized LOC107984007 Neighboring gene uncharacterized LOC105375688 Neighboring gene uncharacterized LOC124902065 Neighboring gene uncharacterized LOC107986899

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Cone-rod synaptic disorder syndrome, congenital nonprogressive
MedGen: C5436505 OMIM: 618970 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0751, DKFZp781A0653

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmembrane transporter binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in calcium ion-regulated exocytosis of neurotransmitter IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in calcium ion-regulated exocytosis of neurotransmitter ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within calcium-ion regulated exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in calcium-ion regulated exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in insulin secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of dendrite extension IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of excitatory postsynaptic potential ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of inhibitory postsynaptic potential ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of membrane potential ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of synaptic plasticity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in spontaneous neurotransmitter secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoskeleton of presynaptic active zone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in presynaptic active zone TAS
Traceable Author Statement
more info
PubMed 
is_active_in presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
regulating synaptic membrane exocytosis protein 2
Names
RAB3 interacting protein 3
Rab3-interacting protein
non-small cell lung cancer RimL3a protein
non-small cell lung cancer RimL3c protein
nuclear protein
rab-3-interacting molecule 2
rab-3-interacting protein 3
rab3-interacting molecule 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053027.1 RefSeqGene

    Range
    5585..761069
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001100117.3NP_001093587.1  regulating synaptic membrane exocytosis protein 2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC012213, AK126939, AP002849, BC043144
    Consensus CDS
    CCDS55269.1
    UniProtKB/Swiss-Prot
    Q9UQ26
    Related
    ENSP00000427018.3, ENST00000504942.6
    Conserved Domains (4) summary
    cd04028
    Location:11801325
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:746869
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:593674
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30154
    PHD_SF; PHD finger superfamily
  2. NM_001282881.2NP_001269810.1  regulating synaptic membrane exocytosis protein 2 isoform c

    See identical proteins and their annotated locations for NP_001269810.1

    Status: REVIEWED

    Source sequence(s)
    AB018294, AP002849, BP230765
    Consensus CDS
    CCDS64948.1
    UniProtKB/Swiss-Prot
    Q9UQ26
    Related
    ENSP00000262231.10, ENST00000262231.14
    Conserved Domains (3) summary
    cd04028
    Location:10191164
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:582708
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:448529
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  3. NM_001282882.2NP_001269811.1  regulating synaptic membrane exocytosis protein 2 isoform d

    See identical proteins and their annotated locations for NP_001269811.1

    Status: REVIEWED

    Source sequence(s)
    AP002849, BP360433, CN361794
    Consensus CDS
    CCDS64949.1
    UniProtKB/Swiss-Prot
    Q9UQ26
    Related
    ENSP00000428478.2, ENST00000523362.6
    Conserved Domains (1) summary
    cd04028
    Location:116261
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
  4. NM_001348484.3NP_001335413.1  regulating synaptic membrane exocytosis protein 2 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) encodes the longest isoform (e).
    Source sequence(s)
    AC007751, AC012213, AC090686, AC107933, AP001572, AP002849
    Related
    ENSP00000512879.1, ENST00000696799.1
    Conserved Domains (4) summary
    cd04028
    Location:14381583
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:818944
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:684765
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30198
    PHD_SF; PHD finger superfamily
  5. NM_001348485.2NP_001335414.1  regulating synaptic membrane exocytosis protein 2 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC012213, AC090686, AC107933, AP001572, AP002849
    Conserved Domains (4) summary
    cd04028
    Location:11041249
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:727853
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:593674
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30154
    PHD_SF; PHD finger superfamily
  6. NM_001348486.2NP_001335415.1  regulating synaptic membrane exocytosis protein 2 isoform g

    Status: REVIEWED

    Source sequence(s)
    AC012213, AC090686, AC107933, AP001572, AP002849
    Conserved Domains (4) summary
    cd04028
    Location:12371382
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:778904
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:644725
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30158
    PHD_SF; PHD finger superfamily
  7. NM_001348487.2NP_001335416.1  regulating synaptic membrane exocytosis protein 2 isoform h

    Status: REVIEWED

    Source sequence(s)
    AC012213, AC090686, AC107933, AP001572, AP002849
    Related
    ENSP00000512880.1, ENST00000696800.1
    Conserved Domains (4) summary
    cd04028
    Location:11901335
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:731857
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:597678
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30158
    PHD_SF; PHD finger superfamily
  8. NM_001348488.2NP_001335417.1  regulating synaptic membrane exocytosis protein 2 isoform i

    Status: REVIEWED

    Source sequence(s)
    AC007751, AC012213, AC090686, AC107933, AP001572, AP002849
    Conserved Domains (4) summary
    cd04028
    Location:12081353
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:771897
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:637718
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30198
    PHD_SF; PHD finger superfamily
  9. NM_001348489.2NP_001335418.1  regulating synaptic membrane exocytosis protein 2 isoform j

    Status: REVIEWED

    Source sequence(s)
    AC012213, AC090686, AC107933, AP001572, AP002849
    Related
    ENSP00000499454.1, ENST00000666250.1
    Conserved Domains (4) summary
    cd04028
    Location:13801525
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:727853
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:593674
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30154
    PHD_SF; PHD finger superfamily
  10. NM_001348490.2NP_001335419.1  regulating synaptic membrane exocytosis protein 2 isoform k

    Status: REVIEWED

    Source sequence(s)
    AC012213, AC090686, AC107933, AP001572, AP002849
    Conserved Domains (4) summary
    cd04028
    Location:13511496
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:731857
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:597678
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30158
    PHD_SF; PHD finger superfamily
  11. NM_001348491.2NP_001335420.1  regulating synaptic membrane exocytosis protein 2 isoform l

    Status: REVIEWED

    Source sequence(s)
    AC007751, AC012213, AC090686, AC107933, AP001572, AP002849
    Related
    ENSP00000499719.1, ENST00000668113.1
    Conserved Domains (5) summary
    cd04028
    Location:12511396
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:814940
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:680761
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30194
    PHD_SF; PHD finger superfamily
    cl28890
    Location:148192
    FYVE_like_SF; FYVE domain like superfamily
  12. NM_001348492.2NP_001335421.1  regulating synaptic membrane exocytosis protein 2 isoform m

    Status: REVIEWED

    Source sequence(s)
    AC012213, AC090686, AC107933, AP001572, AP002849
    Conserved Domains (4) summary
    cd04028
    Location:11791324
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:731857
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:597678
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30158
    PHD_SF; PHD finger superfamily
  13. NM_001348493.2NP_001335422.1  regulating synaptic membrane exocytosis protein 2 isoform n

    Status: REVIEWED

    Source sequence(s)
    AC012213, AC090686, AC107933, AP001572, AP002849
    Conserved Domains (4) summary
    cd04028
    Location:11641309
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:727853
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:593674
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30154
    PHD_SF; PHD finger superfamily
  14. NM_001348494.2NP_001335423.1  regulating synaptic membrane exocytosis protein 2 isoform o

    Status: REVIEWED

    Source sequence(s)
    AC012213, AC090686, AC107933, AP001572, AP002849
    Conserved Domains (4) summary
    cd04028
    Location:12331378
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:774900
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:640721
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30154
    PHD_SF; PHD finger superfamily
  15. NM_001348495.2NP_001335424.1  regulating synaptic membrane exocytosis protein 2 isoform p

    Status: REVIEWED

    Source sequence(s)
    AC012213, AC090686, AC107933, AP001572, AP002849
    Conserved Domains (4) summary
    cd04028
    Location:11891334
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:741867
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:607688
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30154
    PHD_SF; PHD finger superfamily
  16. NM_001348496.2NP_001335425.1  regulating synaptic membrane exocytosis protein 2 isoform q

    Status: REVIEWED

    Source sequence(s)
    AC012213, AC090686, AC107933, AP001572, AP002849
    Conserved Domains (4) summary
    cd04028
    Location:11681313
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:731857
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:597678
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30158
    PHD_SF; PHD finger superfamily
  17. NM_001348497.2NP_001335426.1  regulating synaptic membrane exocytosis protein 2 isoform r

    Status: REVIEWED

    Source sequence(s)
    AC012213, AC090686, AC107933, AP001572, AP002849
    Conserved Domains (4) summary
    cd04028
    Location:11621307
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:774900
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:640721
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30154
    PHD_SF; PHD finger superfamily
  18. NM_001348498.2NP_001335427.1  regulating synaptic membrane exocytosis protein 2 isoform s

    Status: REVIEWED

    Source sequence(s)
    AC090686, AC107933, AP001572, AP002849
    Related
    ENSP00000512882.1, ENST00000696802.1
    Conserved Domains (3) summary
    cd04028
    Location:11551300
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:535661
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:401482
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  19. NM_001348499.2NP_001335428.1  regulating synaptic membrane exocytosis protein 2 isoform t

    Status: REVIEWED

    Source sequence(s)
    AC090686, AC107933, AP001572, AP002849
    Conserved Domains (3) summary
    cd04028
    Location:10161161
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:535661
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:401482
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  20. NM_001348500.2NP_001335429.1  regulating synaptic membrane exocytosis protein 2 isoform u

    Status: REVIEWED

    Source sequence(s)
    AC090686, AC107933, AP001572, AP002849
    Conserved Domains (3) summary
    cd04028
    Location:9341079
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:535661
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:401482
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  21. NM_001348501.2NP_001335430.1  regulating synaptic membrane exocytosis protein 2 isoform v

    Status: REVIEWED

    Source sequence(s)
    AC090686, AC107933, AP001572, AP002849
    Related
    ENSP00000390665.2, ENST00000436393.6
    Conserved Domains (3) summary
    cd04028
    Location:11061251
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:535661
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:401482
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  22. NM_001348502.2NP_001335431.1  regulating synaptic membrane exocytosis protein 2 isoform w

    Status: REVIEWED

    Source sequence(s)
    AC090686, AC107933, AP001572, AP002849
    Conserved Domains (3) summary
    cd04028
    Location:9121057
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:535661
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:401482
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  23. NM_001348503.2NP_001335432.1  regulating synaptic membrane exocytosis protein 2 isoform x

    Status: REVIEWED

    Source sequence(s)
    AC090686, AC107933, AP001572, AP002849
    Conserved Domains (3) summary
    cd04028
    Location:11551300
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:535661
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:401482
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  24. NM_001348504.2NP_001335433.1  regulating synaptic membrane exocytosis protein 2 isoform y

    Status: REVIEWED

    Source sequence(s)
    AC090686, AC107933, AP001572, AP002849
    Conserved Domains (3) summary
    cd04028
    Location:9391084
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:554677
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:401482
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  25. NM_001348505.2NP_001335434.1  regulating synaptic membrane exocytosis protein 2 isoform z

    Status: REVIEWED

    Source sequence(s)
    AC090686, AC107933, AP001572, AP002849
    Conserved Domains (3) summary
    cd04028
    Location:10411186
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:582708
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:448529
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  26. NM_001348506.2NP_001335435.1  regulating synaptic membrane exocytosis protein 2 isoform aa

    Status: REVIEWED

    Source sequence(s)
    AC090686, AC107933, AP001572, AP002849
    Conserved Domains (3) summary
    cd04028
    Location:9721117
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:535661
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:401482
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  27. NM_001348507.2NP_001335436.1  regulating synaptic membrane exocytosis protein 2 isoform bb

    Status: REVIEWED

    Source sequence(s)
    AC090686, AC107933, AP001572, AP002849
    Conserved Domains (3) summary
    cd04028
    Location:9881133
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:554677
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:401482
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  28. NM_001348508.2NP_001335437.1  regulating synaptic membrane exocytosis protein 2 isoform cc

    Status: REVIEWED

    Source sequence(s)
    AC090686, AC107933, AP001572, AP002849
    Conserved Domains (3) summary
    cd04028
    Location:9831128
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:535661
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:401482
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  29. NM_001348509.2NP_001335438.1  regulating synaptic membrane exocytosis protein 2 isoform dd

    Status: REVIEWED

    Source sequence(s)
    AC090686, AC107933, AP001572, AP002849
    Related
    ENSP00000386228.3, ENST00000408894.7
  30. NM_001395652.1NP_001382581.1  regulating synaptic membrane exocytosis protein 2

    Status: REVIEWED

    Source sequence(s)
    AC012213, AC090686, AC107933, AP001572, AP002849
    Conserved Domains (4) summary
    cd04028
    Location:13891534
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:750873
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:597678
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl28890
    Location:108156
    FYVE_like_SF; FYVE domain like superfamily
  31. NM_001395653.1NP_001382582.1  regulating synaptic membrane exocytosis protein 2

    Status: REVIEWED

    Source sequence(s)
    AC007751, AC012213, AC090686, AC107933, AP001572, AP002849
    Conserved Domains (4) summary
    cd04028
    Location:13421487
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:771897
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:637718
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl28890
    Location:148196
    FYVE_like_SF; FYVE domain like superfamily
  32. NM_001395654.1NP_001382583.1  regulating synaptic membrane exocytosis protein 2

    Status: REVIEWED

    Source sequence(s)
    AC007751, AC012213, AC090686, AC107933, AP001572, AP002849
    Conserved Domains (4) summary
    cd04028
    Location:13911536
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:771897
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:637718
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl28890
    Location:148196
    FYVE_like_SF; FYVE domain like superfamily
  33. NM_014677.5NP_055492.3  regulating synaptic membrane exocytosis protein 2 isoform b

    See identical proteins and their annotated locations for NP_055492.3

    Status: REVIEWED

    Source sequence(s)
    AK126939, AP002849, BC043144, BP230765
    Consensus CDS
    CCDS43761.1
    UniProtKB/Swiss-Prot
    Q9UQ26
    Related
    ENSP00000423559.1, ENST00000507740.6
    Conserved Domains (4) summary
    cd04028
    Location:9941139
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:535661
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA02666
    Location:762864
    PHA02666; hypothetical protein; Provisional
    cd00992
    Location:401482
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RNA

  1. NR_145710.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007751, AC012213, AC090686, AC107933, AP001572, AP002849
  2. NR_145711.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC090686, AC107933, AP001572, AP002849

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    103500610..104256094
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014015.3XP_016869504.1  regulating synaptic membrane exocytosis protein 2 isoform X21

  2. XM_017014010.3XP_016869499.1  regulating synaptic membrane exocytosis protein 2 isoform X12

  3. XM_017014016.3XP_016869505.1  regulating synaptic membrane exocytosis protein 2 isoform X22

  4. XM_047422473.1XP_047278429.1  regulating synaptic membrane exocytosis protein 2 isoform X9

  5. XM_017014009.3XP_016869498.1  regulating synaptic membrane exocytosis protein 2 isoform X10

  6. XM_011517395.4XP_011515697.1  regulating synaptic membrane exocytosis protein 2 isoform X1

    Conserved Domains (4) summary
    cd04028
    Location:15411686
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:851974
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:698779
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30198
    PHD_SF; PHD finger superfamily
  7. XM_017014008.3XP_016869497.1  regulating synaptic membrane exocytosis protein 2 isoform X5

  8. XM_017014006.3XP_016869495.1  regulating synaptic membrane exocytosis protein 2 isoform X2

  9. XM_017014011.3XP_016869500.1  regulating synaptic membrane exocytosis protein 2 isoform X13

  10. XM_047422468.1XP_047278424.1  regulating synaptic membrane exocytosis protein 2 isoform X3

  11. XM_017014012.3XP_016869501.1  regulating synaptic membrane exocytosis protein 2 isoform X16

  12. XM_047422469.1XP_047278425.1  regulating synaptic membrane exocytosis protein 2 isoform X4

  13. XM_047422475.1XP_047278431.1  regulating synaptic membrane exocytosis protein 2 isoform X14

  14. XM_047422476.1XP_047278432.1  regulating synaptic membrane exocytosis protein 2 isoform X15

  15. XM_047422477.1XP_047278433.1  regulating synaptic membrane exocytosis protein 2 isoform X17

  16. XM_047422481.1XP_047278437.1  regulating synaptic membrane exocytosis protein 2 isoform X26

  17. XM_047422470.1XP_047278426.1  regulating synaptic membrane exocytosis protein 2 isoform X6

  18. XM_047422471.1XP_047278427.1  regulating synaptic membrane exocytosis protein 2 isoform X7

  19. XM_047422472.1XP_047278428.1  regulating synaptic membrane exocytosis protein 2 isoform X8

  20. XM_047422480.1XP_047278436.1  regulating synaptic membrane exocytosis protein 2 isoform X24

  21. XM_047422479.1XP_047278435.1  regulating synaptic membrane exocytosis protein 2 isoform X19

  22. XM_017014014.2XP_016869503.1  regulating synaptic membrane exocytosis protein 2 isoform X20

  23. XM_047422482.1XP_047278438.1  regulating synaptic membrane exocytosis protein 2 isoform X27

  24. XM_047422478.1XP_047278434.1  regulating synaptic membrane exocytosis protein 2 isoform X18

  25. XM_005251106.4XP_005251163.1  regulating synaptic membrane exocytosis protein 2 isoform X23

    Conserved Domains (5) summary
    cd04028
    Location:14051550
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:774900
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA02666
    Location:10011103
    PHA02666; hypothetical protein; Provisional
    cd00992
    Location:640721
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30154
    PHD_SF; PHD finger superfamily
  26. XM_047422474.1XP_047278430.1  regulating synaptic membrane exocytosis protein 2 isoform X11

  27. XM_005251107.4XP_005251164.1  regulating synaptic membrane exocytosis protein 2 isoform X25

    Conserved Domains (4) summary
    cd04028
    Location:13831528
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:774900
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:640721
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30154
    PHD_SF; PHD finger superfamily
  28. XM_047422483.1XP_047278439.1  regulating synaptic membrane exocytosis protein 2 isoform X29

  29. XM_017014036.2XP_016869525.1  regulating synaptic membrane exocytosis protein 2 isoform X30

  30. XM_017014022.2XP_016869511.1  regulating synaptic membrane exocytosis protein 2 isoform X28

  31. XM_006716698.4XP_006716761.1  regulating synaptic membrane exocytosis protein 2 isoform X31

    Conserved Domains (1) summary
    cd04028
    Location:144289
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    104628208..105383642
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)