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RIMS2 regulating synaptic membrane exocytosis 2 [ Homo sapiens (human) ]

Gene ID: 9699, updated on 2-Mar-2021

Summary

Official Symbol
RIMS2provided by HGNC
Official Full Name
regulating synaptic membrane exocytosis 2provided by HGNC
Primary source
HGNC:HGNC:17283
See related
Ensembl:ENSG00000176406 MIM:606630
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OBOE; RIM2; CRSDS; RAB3IP3
Summary
The protein encoded by this gene is a presynaptic protein that interacts with RAB3, a protein important for normal neurotransmitter release. The encoded protein can also bind several other synaptic proteins, including UNC-13 homolog B, ELKS/Rab6-interacting/CAST family member 1, and synaptotagmin 1. This protein is involved in synaptic membrane exocytosis. Polymorphisms in this gene have been associated with degenerative lumbar scoliosis. [provided by RefSeq, Feb 2017]
Expression
Biased expression in adrenal (RPKM 12.7), brain (RPKM 6.8) and 1 other tissue See more
Orthologs
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Genomic context

See RIMS2 in Genome Data Viewer
Location:
8q22.3
Exon count:
42
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (103499934..104256094)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (104512838..105268322)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 32 Neighboring gene uncharacterized LOC105375690 Neighboring gene DDB1 and CUL4 associated factor 13 Neighboring gene Sharpr-MPRA regulatory region 6081 Neighboring gene mediator complex subunit 21 pseudogene Neighboring gene prothymosin alpha pseudogene 15 Neighboring gene TARBP2 pseudogene 1 Neighboring gene ribosomal protein S6 pseudogene 9 Neighboring gene uncharacterized LOC105375689 Neighboring gene uncharacterized LOC107984007 Neighboring gene uncharacterized LOC105375688 Neighboring gene uncharacterized LOC107986899 Neighboring gene dendrocyte expressed seven transmembrane protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Cone-rod synaptic disorder syndrome, congenital nonprogressive
MedGen: CN295021 OMIM: 618970 GeneReviews: Not available
not available
Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0751, DKFZp781A0653

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ion channel binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ion channel binding ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cAMP-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium ion-regulated exocytosis of neurotransmitter IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion-regulated exocytosis of neurotransmitter ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium-ion regulated exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
insulin secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
positive regulation of dendrite extension IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of excitatory postsynaptic potential ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of inhibitory postsynaptic potential ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of membrane potential ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of synaptic plasticity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of synaptic vesicle exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spontaneous neurotransmitter secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton of presynaptic active zone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
presynaptic active zone TAS
Traceable Author Statement
more info
PubMed 
presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
regulating synaptic membrane exocytosis protein 2
Names
RAB3 interacting protein 3
Rab3-interacting protein
non-small cell lung cancer RimL3a protein
non-small cell lung cancer RimL3c protein
nuclear protein
rab-3-interacting molecule 2
rab-3-interacting protein 3
rab3-interacting molecule 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053027.1 RefSeqGene

    Range
    5585..761069
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001100117.3NP_001093587.1  regulating synaptic membrane exocytosis protein 2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC012213, AK126939, AP002849, BC043144
    Consensus CDS
    CCDS55269.1
    UniProtKB/Swiss-Prot
    Q9UQ26
    Related
    ENSP00000427018.3, ENST00000504942.6
    Conserved Domains (4) summary
    cd04028
    Location:11801325
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:746869
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:593674
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30154
    PHD_SF; PHD finger superfamily
  2. NM_001282881.2NP_001269810.1  regulating synaptic membrane exocytosis protein 2 isoform c

    See identical proteins and their annotated locations for NP_001269810.1

    Status: REVIEWED

    Source sequence(s)
    AB018294, AP002849, BP230765
    Consensus CDS
    CCDS64948.1
    UniProtKB/Swiss-Prot
    Q9UQ26
    Related
    ENSP00000262231.10, ENST00000262231.14
    Conserved Domains (3) summary
    cd04028
    Location:10191164
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:582708
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:448529
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  3. NM_001282882.2NP_001269811.1  regulating synaptic membrane exocytosis protein 2 isoform d

    See identical proteins and their annotated locations for NP_001269811.1

    Status: REVIEWED

    Source sequence(s)
    AP002849, BP360433, CN361794
    Consensus CDS
    CCDS64949.1
    UniProtKB/Swiss-Prot
    Q9UQ26
    Related
    ENSP00000342051.2, ENST00000339750.3
    Conserved Domains (1) summary
    cd04028
    Location:116261
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
  4. NM_001348484.2NP_001335413.1  regulating synaptic membrane exocytosis protein 2 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) encodes the longest isoform (e).
    Source sequence(s)
    AC007751, AC012213, AC090686, AC107933, AP001572, AP002849
    Conserved Domains (4) summary
    cd04028
    Location:14381583
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:818944
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:684765
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30198
    PHD_SF; PHD finger superfamily
  5. NM_001348485.2NP_001335414.1  regulating synaptic membrane exocytosis protein 2 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC012213, AC090686, AC107933, AP001572, AP002849
    Conserved Domains (4) summary
    cd04028
    Location:11041249
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:727853
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:593674
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30154
    PHD_SF; PHD finger superfamily
  6. NM_001348486.2NP_001335415.1  regulating synaptic membrane exocytosis protein 2 isoform g

    Status: REVIEWED

    Source sequence(s)
    AC012213, AC090686, AC107933, AP001572, AP002849
    Conserved Domains (4) summary
    cd04028
    Location:12371382
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:778904
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:644725
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30158
    PHD_SF; PHD finger superfamily
  7. NM_001348487.2NP_001335416.1  regulating synaptic membrane exocytosis protein 2 isoform h

    Status: REVIEWED

    Source sequence(s)
    AC012213, AC090686, AC107933, AP001572, AP002849
    Related
    ENSP00000487907.1, ENST00000632716.1
    Conserved Domains (4) summary
    cd04028
    Location:11901335
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:731857
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:597678
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30158
    PHD_SF; PHD finger superfamily
  8. NM_001348488.2NP_001335417.1  regulating synaptic membrane exocytosis protein 2 isoform i

    Status: REVIEWED

    Source sequence(s)
    AC007751, AC012213, AC090686, AC107933, AP001572, AP002849
    Conserved Domains (4) summary
    cd04028
    Location:12081353
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:771897
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:637718
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30198
    PHD_SF; PHD finger superfamily
  9. NM_001348489.2NP_001335418.1  regulating synaptic membrane exocytosis protein 2 isoform j

    Status: REVIEWED

    Source sequence(s)
    AC012213, AC090686, AC107933, AP001572, AP002849
    Related
    ENSP00000499454.1, ENST00000666250.1
    Conserved Domains (4) summary
    cd04028
    Location:13801525
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:727853
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:593674
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30154
    PHD_SF; PHD finger superfamily
  10. NM_001348490.2NP_001335419.1  regulating synaptic membrane exocytosis protein 2 isoform k

    Status: REVIEWED

    Source sequence(s)
    AC012213, AC090686, AC107933, AP001572, AP002849
    Conserved Domains (4) summary
    cd04028
    Location:13511496
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:731857
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:597678
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30158
    PHD_SF; PHD finger superfamily
  11. NM_001348491.2NP_001335420.1  regulating synaptic membrane exocytosis protein 2 isoform l

    Status: REVIEWED

    Source sequence(s)
    AC007751, AC012213, AC090686, AC107933, AP001572, AP002849
    Conserved Domains (5) summary
    cd04028
    Location:12511396
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:814940
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:680761
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30194
    PHD_SF; PHD finger superfamily
    cl28890
    Location:148192
    FYVE_like_SF; FYVE domain like superfamily
  12. NM_001348492.2NP_001335421.1  regulating synaptic membrane exocytosis protein 2 isoform m

    Status: REVIEWED

    Source sequence(s)
    AC012213, AC090686, AC107933, AP001572, AP002849
    Conserved Domains (4) summary
    cd04028
    Location:11791324
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:731857
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:597678
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30158
    PHD_SF; PHD finger superfamily
  13. NM_001348493.2NP_001335422.1  regulating synaptic membrane exocytosis protein 2 isoform n

    Status: REVIEWED

    Source sequence(s)
    AC012213, AC090686, AC107933, AP001572, AP002849
    Conserved Domains (4) summary
    cd04028
    Location:11641309
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:727853
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:593674
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30154
    PHD_SF; PHD finger superfamily
  14. NM_001348494.2NP_001335423.1  regulating synaptic membrane exocytosis protein 2 isoform o

    Status: REVIEWED

    Source sequence(s)
    AC012213, AC090686, AC107933, AP001572, AP002849
    Conserved Domains (4) summary
    cd04028
    Location:12331378
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:774900
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:640721
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30154
    PHD_SF; PHD finger superfamily
  15. NM_001348495.2NP_001335424.1  regulating synaptic membrane exocytosis protein 2 isoform p

    Status: REVIEWED

    Source sequence(s)
    AC012213, AC090686, AC107933, AP001572, AP002849
    Conserved Domains (4) summary
    cd04028
    Location:11891334
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:741867
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:607688
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30154
    PHD_SF; PHD finger superfamily
  16. NM_001348496.2NP_001335425.1  regulating synaptic membrane exocytosis protein 2 isoform q

    Status: REVIEWED

    Source sequence(s)
    AC012213, AC090686, AC107933, AP001572, AP002849
    Conserved Domains (4) summary
    cd04028
    Location:11681313
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:731857
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:597678
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30158
    PHD_SF; PHD finger superfamily
  17. NM_001348497.2NP_001335426.1  regulating synaptic membrane exocytosis protein 2 isoform r

    Status: REVIEWED

    Source sequence(s)
    AC012213, AC090686, AC107933, AP001572, AP002849
    Conserved Domains (4) summary
    cd04028
    Location:11621307
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:774900
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:640721
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30154
    PHD_SF; PHD finger superfamily
  18. NM_001348498.2NP_001335427.1  regulating synaptic membrane exocytosis protein 2 isoform s

    Status: REVIEWED

    Source sequence(s)
    AC090686, AC107933, AP001572, AP002849
    Conserved Domains (3) summary
    cd04028
    Location:11551300
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:535661
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:401482
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  19. NM_001348499.2NP_001335428.1  regulating synaptic membrane exocytosis protein 2 isoform t

    Status: REVIEWED

    Source sequence(s)
    AC090686, AC107933, AP001572, AP002849
    Conserved Domains (3) summary
    cd04028
    Location:10161161
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:535661
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:401482
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  20. NM_001348500.2NP_001335429.1  regulating synaptic membrane exocytosis protein 2 isoform u

    Status: REVIEWED

    Source sequence(s)
    AC090686, AC107933, AP001572, AP002849
    Conserved Domains (3) summary
    cd04028
    Location:9341079
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:535661
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:401482
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  21. NM_001348501.2NP_001335430.1  regulating synaptic membrane exocytosis protein 2 isoform v

    Status: REVIEWED

    Source sequence(s)
    AC090686, AC107933, AP001572, AP002849
    Conserved Domains (3) summary
    cd04028
    Location:11061251
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:535661
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:401482
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  22. NM_001348502.2NP_001335431.1  regulating synaptic membrane exocytosis protein 2 isoform w

    Status: REVIEWED

    Source sequence(s)
    AC090686, AC107933, AP001572, AP002849
    Conserved Domains (3) summary
    cd04028
    Location:9121057
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:535661
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:401482
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  23. NM_001348503.2NP_001335432.1  regulating synaptic membrane exocytosis protein 2 isoform x

    Status: REVIEWED

    Source sequence(s)
    AC090686, AC107933, AP001572, AP002849
    Conserved Domains (3) summary
    cd04028
    Location:11551300
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:535661
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:401482
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  24. NM_001348504.2NP_001335433.1  regulating synaptic membrane exocytosis protein 2 isoform y

    Status: REVIEWED

    Source sequence(s)
    AC090686, AC107933, AP001572, AP002849
    Conserved Domains (3) summary
    cd04028
    Location:9391084
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:554677
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:401482
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  25. NM_001348505.2NP_001335434.1  regulating synaptic membrane exocytosis protein 2 isoform z

    Status: REVIEWED

    Source sequence(s)
    AC090686, AC107933, AP001572, AP002849
    Conserved Domains (3) summary
    cd04028
    Location:10411186
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:582708
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:448529
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  26. NM_001348506.2NP_001335435.1  regulating synaptic membrane exocytosis protein 2 isoform aa

    Status: REVIEWED

    Source sequence(s)
    AC090686, AC107933, AP001572, AP002849
    Conserved Domains (3) summary
    cd04028
    Location:9721117
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:535661
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:401482
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  27. NM_001348507.2NP_001335436.1  regulating synaptic membrane exocytosis protein 2 isoform bb

    Status: REVIEWED

    Source sequence(s)
    AC090686, AC107933, AP001572, AP002849
    Conserved Domains (3) summary
    cd04028
    Location:9881133
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:554677
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:401482
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  28. NM_001348508.2NP_001335437.1  regulating synaptic membrane exocytosis protein 2 isoform cc

    Status: REVIEWED

    Source sequence(s)
    AC090686, AC107933, AP001572, AP002849
    Conserved Domains (3) summary
    cd04028
    Location:9831128
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:535661
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:401482
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  29. NM_001348509.2NP_001335438.1  regulating synaptic membrane exocytosis protein 2 isoform dd

    Status: REVIEWED

    Source sequence(s)
    AC090686, AC107933, AP001572, AP002849
    Conserved Domains (3) summary
    cd04028
    Location:11871332
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:535661
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:401482
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  30. NM_014677.5NP_055492.3  regulating synaptic membrane exocytosis protein 2 isoform b

    See identical proteins and their annotated locations for NP_055492.3

    Status: REVIEWED

    Source sequence(s)
    AK126939, AP002849, BC043144, BP230765
    Consensus CDS
    CCDS43761.1
    UniProtKB/Swiss-Prot
    Q9UQ26
    Related
    ENSP00000423559.1, ENST00000507740.5
    Conserved Domains (4) summary
    cd04028
    Location:9941139
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:535661
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA02666
    Location:762864
    PHA02666; hypothetical protein; Provisional
    cd00992
    Location:401482
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RNA

  1. NR_145710.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007751, AC012213, AC090686, AC107933, AP001572, AP002849
  2. NR_145711.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC090686, AC107933, AP001572, AP002849

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    103499934..104256094
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014034.2XP_016869523.1  regulating synaptic membrane exocytosis protein 2 isoform X29

  2. XM_017014015.2XP_016869504.1  regulating synaptic membrane exocytosis protein 2 isoform X15

  3. XM_017014028.2XP_016869517.1  regulating synaptic membrane exocytosis protein 2 isoform X28

  4. XM_017014010.2XP_016869499.1  regulating synaptic membrane exocytosis protein 2 isoform X10

  5. XM_017014027.2XP_016869516.1  regulating synaptic membrane exocytosis protein 2 isoform X27

  6. XM_017014016.2XP_016869505.1  regulating synaptic membrane exocytosis protein 2 isoform X16

  7. XM_017014017.2XP_016869506.1  regulating synaptic membrane exocytosis protein 2 isoform X18

  8. XM_017014021.2XP_016869510.1  regulating synaptic membrane exocytosis protein 2 isoform X21

  9. XM_017014007.2XP_016869496.1  regulating synaptic membrane exocytosis protein 2 isoform X3

  10. XM_024447342.1XP_024303110.1  regulating synaptic membrane exocytosis protein 2 isoform X5

    Conserved Domains (4) summary
    cd04028
    Location:14951640
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:851974
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:698779
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30198
    PHD_SF; PHD finger superfamily
  11. XM_024447343.1XP_024303111.1  regulating synaptic membrane exocytosis protein 2 isoform X6

    Conserved Domains (4) summary
    cd04028
    Location:14841629
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:851974
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:698779
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30198
    PHD_SF; PHD finger superfamily
  12. XM_024447344.1XP_024303112.1  regulating synaptic membrane exocytosis protein 2 isoform X7

    Conserved Domains (4) summary
    cd04028
    Location:14731618
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:851974
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:698779
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30198
    PHD_SF; PHD finger superfamily
  13. XM_024447346.1XP_024303114.1  regulating synaptic membrane exocytosis protein 2 isoform X14

    Conserved Domains (4) summary
    cd04028
    Location:14131558
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:851974
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:698779
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30198
    PHD_SF; PHD finger superfamily
  14. XM_011517398.3XP_011515700.1  regulating synaptic membrane exocytosis protein 2 isoform X23

    Conserved Domains (5) summary
    cd04028
    Location:13071452
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:851974
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA02666
    Location:10751177
    PHA02666; hypothetical protein; Provisional
    cd00992
    Location:698779
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30198
    PHD_SF; PHD finger superfamily
  15. XM_017014009.2XP_016869498.1  regulating synaptic membrane exocytosis protein 2 isoform X8

  16. XM_011517395.3XP_011515697.1  regulating synaptic membrane exocytosis protein 2 isoform X1

    Conserved Domains (4) summary
    cd04028
    Location:15411686
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:851974
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:698779
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30198
    PHD_SF; PHD finger superfamily
  17. XM_017014024.2XP_016869513.1  regulating synaptic membrane exocytosis protein 2 isoform X26

    Related
    ENSP00000499719.1, ENST00000668113.1
  18. XM_017014008.2XP_016869497.1  regulating synaptic membrane exocytosis protein 2 isoform X4

  19. XM_024447345.1XP_024303113.1  regulating synaptic membrane exocytosis protein 2 isoform X9

    Conserved Domains (4) summary
    cd04028
    Location:14571602
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:832958
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:698779
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30198
    PHD_SF; PHD finger superfamily
  20. XM_017014023.2XP_016869512.1  regulating synaptic membrane exocytosis protein 2 isoform X24

  21. XM_024447347.1XP_024303115.1  regulating synaptic membrane exocytosis protein 2 isoform X25

    Conserved Domains (4) summary
    cd04028
    Location:12911436
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:832958
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:698779
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30198
    PHD_SF; PHD finger superfamily
  22. XM_017014006.2XP_016869495.1  regulating synaptic membrane exocytosis protein 2 isoform X2

  23. XM_017014011.2XP_016869500.1  regulating synaptic membrane exocytosis protein 2 isoform X11

  24. XM_017014012.2XP_016869501.1  regulating synaptic membrane exocytosis protein 2 isoform X12

  25. XM_017014019.2XP_016869508.1  regulating synaptic membrane exocytosis protein 2 isoform X20

  26. XM_017014014.1XP_016869503.1  regulating synaptic membrane exocytosis protein 2 isoform X13

  27. XM_005251106.3XP_005251163.1  regulating synaptic membrane exocytosis protein 2 isoform X17

    Conserved Domains (5) summary
    cd04028
    Location:14051550
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:774900
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA02666
    Location:10011103
    PHA02666; hypothetical protein; Provisional
    cd00992
    Location:640721
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30154
    PHD_SF; PHD finger superfamily
  28. XM_005251107.3XP_005251164.1  regulating synaptic membrane exocytosis protein 2 isoform X19

    Conserved Domains (4) summary
    cd04028
    Location:13831528
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:774900
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:640721
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl22851
    Location:30154
    PHD_SF; PHD finger superfamily
  29. XM_017014036.1XP_016869525.1  regulating synaptic membrane exocytosis protein 2 isoform X30

    Related
    ENSP00000386228.2, ENST00000408894.6
  30. XM_017014022.1XP_016869511.1  regulating synaptic membrane exocytosis protein 2 isoform X22

  31. XM_006716698.3XP_006716761.1  regulating synaptic membrane exocytosis protein 2 isoform X31

    Conserved Domains (1) summary
    cd04028
    Location:144289
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
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