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PRORP protein only RNase P catalytic subunit [ Homo sapiens (human) ]

Gene ID: 9692, updated on 11-Jun-2021

Summary

Official Symbol
PRORPprovided by HGNC
Official Full Name
protein only RNase P catalytic subunitprovided by HGNC
Primary source
HGNC:HGNC:19958
See related
Ensembl:ENSG00000100890 Ensembl:ENSG00000258790 MIM:609947
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRPP3; KIAA0391
Expression
Ubiquitous expression in testis (RPKM 10.2), kidney (RPKM 8.4) and 25 other tissues See more
Orthologs
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Genomic context

See PRORP in Genome Data Viewer
Location:
14q13.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (35122303..35277622)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (35591758..35746828)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene signal recognition particle 54 Neighboring gene family with sequence similarity 177 member A1 Neighboring gene uncharacterized LOC101927178 Neighboring gene protein phosphatase 2 regulatory subunit B''gamma Neighboring gene ribosomal protein L23a pseudogene 70 Neighboring gene septin 7 pseudogene 1 Neighboring gene mitochondrial ribosomal protein L57 pseudogene 8 Neighboring gene divergent-paired related homeobox pseudogene 3 Neighboring gene ribosomal protein L7a pseudogene 3 Neighboring gene ribosomal protein L9 pseudogene 3 Neighboring gene proteasome 20S subunit alpha 6 Neighboring gene Sharpr-MPRA regulatory region 8744

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association analysis identifies three psoriasis susceptibility loci.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables ribonuclease P activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ribonuclease P activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA phosphodiester bond hydrolysis, endonucleolytic IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrial tRNA 5'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitochondrial tRNA 5'-end processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitochondrial tRNA methylation TAS
Traceable Author Statement
more info
 
involved_in tRNA 5'-leader removal IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrial matrix TAS
Traceable Author Statement
more info
 
part_of mitochondrial ribonuclease P complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of mitochondrial ribonuclease P complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of mitochondrial ribonuclease P complex TAS
Traceable Author Statement
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
mitochondrial ribonuclease P catalytic subunit
Names
mitochondrial RNase P protein 3
mitochondrial RNase P subunit 3
mitochondrial ribonuclease P protein 3
proteinaceous RNase P
NP_001243607.1
NP_001243608.1
NP_001243609.1
NP_001243610.1
NP_055487.2
XP_005268294.1
XP_011535712.1
XP_016877325.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256678.2NP_001243607.1  mitochondrial ribonuclease P catalytic subunit isoform 2

    See identical proteins and their annotated locations for NP_001243607.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB002389, AK304066, AL121594, DA459368
    Consensus CDS
    CCDS58312.1
    UniProtKB/Swiss-Prot
    O15091
    Related
    ENSP00000250377.8, ENST00000250377.11
    Conserved Domains (2) summary
    sd00004
    Location:174204
    PPR; PPR repeat [structural motif]
    pfam16953
    Location:328562
    PRORP; Protein-only RNase P
  2. NM_001256679.2NP_001243608.1  mitochondrial ribonuclease P catalytic subunit isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AI431599, AK301931, AL121594, BP373829
    Consensus CDS
    CCDS58313.1
    UniProtKB/Swiss-Prot
    O15091
    Related
    ENSP00000474620.1, ENST00000604948.5
    Conserved Domains (2) summary
    sd00004
    Location:79109
    PPR; PPR repeat [structural motif]
    pfam16953
    Location:247483
    PRORP; Protein-only RNase P
  3. NM_001256680.2NP_001243609.1  mitochondrial ribonuclease P catalytic subunit isoform 4

    See identical proteins and their annotated locations for NP_001243609.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 4 and 5 encode the same isoform (4), which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AA838769, AL121594, BX161487, DC404874
    Consensus CDS
    CCDS58314.1
    UniProtKB/Swiss-Prot
    O15091
    Related
    ENSP00000474299.1, ENST00000605870.5
    Conserved Domains (1) summary
    pfam16953
    Location:1206
    PRORP; Protein-only RNase P
  4. NM_001256681.2NP_001243610.1  mitochondrial ribonuclease P catalytic subunit isoform 4

    See identical proteins and their annotated locations for NP_001243610.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 4 and 5 encode the same isoform (4), which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AI431599, AL121594, BQ063741, DC404874, DT217089
    Consensus CDS
    CCDS58314.1
    UniProtKB/Swiss-Prot
    O15091
    Related
    ENSP00000324697.9, ENST00000321130.14
    Conserved Domains (1) summary
    pfam16953
    Location:1206
    PRORP; Protein-only RNase P
  5. NM_014672.4NP_055487.2  mitochondrial ribonuclease P catalytic subunit isoform 1 precursor

    See identical proteins and their annotated locations for NP_055487.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA838769, AL121594, BX161394, DA459368
    Consensus CDS
    CCDS32063.1
    UniProtKB/Swiss-Prot
    O15091
    Related
    ENSP00000440915.2, ENST00000534898.9
    Conserved Domains (2) summary
    sd00004
    Location:174204
    PPR; PPR repeat [structural motif]
    pfam16953
    Location:342578
    PRORP; Protein-only RNase P

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    35122303..35277622
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537410.2XP_011535712.1  mitochondrial ribonuclease P catalytic subunit isoform X1

    See identical proteins and their annotated locations for XP_011535712.1

    UniProtKB/Swiss-Prot
    O15091
    Conserved Domains (2) summary
    sd00004
    Location:174204
    PPR; PPR repeat [structural motif]
    pfam16953
    Location:342578
    PRORP; Protein-only RNase P
  2. XM_017021836.1XP_016877325.1  mitochondrial ribonuclease P catalytic subunit isoform X2

    UniProtKB/Swiss-Prot
    O15091
    Related
    ENSP00000473856.1, ENST00000603544.5
    Conserved Domains (2) summary
    sd00004
    Location:174204
    PPR; PPR repeat [structural motif]
    pfam16953
    Location:328562
    PRORP; Protein-only RNase P
  3. XM_005268237.3XP_005268294.1  mitochondrial ribonuclease P catalytic subunit isoform X1

    See identical proteins and their annotated locations for XP_005268294.1

    UniProtKB/Swiss-Prot
    O15091
    Related
    ENSP00000454657.1, ENST00000557565.1
    Conserved Domains (2) summary
    sd00004
    Location:174204
    PPR; PPR repeat [structural motif]
    pfam16953
    Location:342578
    PRORP; Protein-only RNase P
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