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EIF5B eukaryotic translation initiation factor 5B [ Homo sapiens (human) ]

Gene ID: 9669, updated on 5-Sep-2021

Summary

Official Symbol
EIF5Bprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 5Bprovided by HGNC
Primary source
HGNC:HGNC:30793
See related
Ensembl:ENSG00000158417 MIM:606086
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IF2
Summary
Accurate initiation of translation in eukaryotes is complex and requires many factors, some of which are composed of multiple subunits. The process is simpler in prokaryotes which have only three initiation factors (IF1, IF2, IF3). Two of these factors are conserved in eukaryotes: the homolog of IF1 is eIF1A and the homolog of IF2 is eIF5B. This gene encodes eIF5B. Factors eIF1A and eIF5B interact on the ribosome along with other initiation factors and GTP to position the initiation methionine tRNA on the start codon of the mRNA so that translation initiates accurately. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in heart (RPKM 26.2), testis (RPKM 23.3) and 25 other tissues See more
Orthologs
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Genomic context

See EIF5B in Genome Data Viewer
Location:
2q11.2
Exon count:
24
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (99337389..99401326)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (99953852..100017789)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985923 Neighboring gene thioredoxin domain containing 9 Neighboring gene lysozyme g1 Neighboring gene REV1 DNA directed polymerase Neighboring gene AF4/FMR2 family member 3 Neighboring gene uncharacterized LOC105373504 Neighboring gene uncharacterized LOC112268421

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag interacts with EIF5B as demonstrated by proximity dependent biotinylation proteomics PubMed
matrix gag HIV-1 Matrix inhibits hIF2 mediated translation in a reticulocyte lysate assay PubMed
gag HIV-1 Matrix, as well as the full length HIV-1 Gag protein bind to human translation initiation factor two (hIF2) and these proteins can be immunoprecipitated as a protein complex PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10524, KIAA0741, DKFZp434I036

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding HDA PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables translation initiation factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables translation initiation factor activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of translational initiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
NOT located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
eukaryotic translation initiation factor 5B
Names
eIF-5B
translation initiation factor IF-2
translation initiation factor IF2
NP_056988.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015904.4NP_056988.3  eukaryotic translation initiation factor 5B

    See identical proteins and their annotated locations for NP_056988.3

    Status: REVIEWED

    Source sequence(s)
    AB018284, AC018690, BC032639, BX485839
    Consensus CDS
    CCDS42721.1
    UniProtKB/Swiss-Prot
    O60841
    UniProtKB/TrEMBL
    Q8N5A0
    Related
    ENSP00000289371.5, ENST00000289371.11
    Conserved Domains (6) summary
    cd01887
    Location:632845
    IF2_eIF5B; Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family
    PRK04004
    Location:6271202
    PRK04004; translation initiation factor IF-2; Validated
    pfam08070
    Location:110171
    DTHCT; DTHCT (NUC029) region
    pfam11987
    Location:9661067
    IF-2; Translation-initiation factor 2
    cd03703
    Location:855965
    aeIF5B_II; Domain II of archaeal and eukaryotic Initiation Factor 5
    cd16266
    Location:10921186
    IF2_aeIF5B_IV; Domain IV of prokaryotic Initiation Factor 2 and archaeal and eukaryotic Initiation Factor 5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    99337389..99401326
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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