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TTLL4 tubulin tyrosine ligase like 4 [ Homo sapiens (human) ]

Gene ID: 9654, updated on 12-Aug-2022

Summary

Official Symbol
TTLL4provided by HGNC
Official Full Name
tubulin tyrosine ligase like 4provided by HGNC
Primary source
HGNC:HGNC:28976
See related
Ensembl:ENSG00000135912 MIM:618738; AllianceGenome:HGNC:28976
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in microtubule cytoskeleton organization and protein polyglutamylation. Predicted to act upstream of or within regulation of blastocyst development. Predicted to be located in cytosol. Predicted to be active in cilium. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 10.4), brain (RPKM 3.1) and 24 other tissues See more
Orthologs
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Genomic context

See TTLL4 in Genome Data Viewer
Location:
2q35
Exon count:
21
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (218710835..218759724)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (219197391..219241970)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (219575558..219620139)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ring finger protein 25 Neighboring gene serine/threonine kinase 36 Neighboring gene uncharacterized LOC124907983 Neighboring gene cytochrome P450 family 27 subfamily A member 1 Neighboring gene microRNA 9500 Neighboring gene protein kinase AMP-activated non-catalytic subunit gamma 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0173

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein-glutamic acid ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables tubulin binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables tubulin-glutamic acid ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables tubulin-glutamic acid ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables tubulin-glutamic acid ligase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-glutamic acid modification ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein polyglutamylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein polyglutamylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in protein polyglutamylation TAS
Traceable Author Statement
more info
 
involved_in regulation of blastocyst development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in 9+0 non-motile cilium IEA
Inferred from Electronic Annotation
more info
 
located_in ciliary basal body IEA
Inferred from Electronic Annotation
more info
 
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tubulin monoglutamylase TTLL4
Names
protein monoglutamylase TTLL4
tubulin polyglutamylase TTLL4
tubulin tyrosine ligase-like family, member 4
tubulin--tyrosine ligase-like protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014640.5NP_055455.3  tubulin monoglutamylase TTLL4

    See identical proteins and their annotated locations for NP_055455.3

    Status: VALIDATED

    Source sequence(s)
    AC009974, AK291770, DB097392
    Consensus CDS
    CCDS2422.1
    UniProtKB/Swiss-Prot
    Q14679, Q8WW29
    UniProtKB/TrEMBL
    A0A024R424
    Related
    ENSP00000375951.1, ENST00000392102.6
    Conserved Domains (1) summary
    pfam03133
    Location:654946
    TTL; Tubulin-tyrosine ligase family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    218710835..218759724
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047446455.1XP_047302411.1  tubulin monoglutamylase TTLL4 isoform X4

  2. XM_047446454.1XP_047302410.1  tubulin monoglutamylase TTLL4 isoform X3

  3. XM_006712875.3XP_006712938.1  tubulin monoglutamylase TTLL4 isoform X4

    Conserved Domains (1) summary
    pfam03133
    Location:654946
    TTL; Tubulin-tyrosine ligase family
  4. XM_047446456.1XP_047302412.1  tubulin monoglutamylase TTLL4 isoform X4

  5. XM_047446457.1XP_047302413.1  tubulin monoglutamylase TTLL4 isoform X4

    Related
    ENSP00000393332.1, ENST00000457313.5
  6. XM_017005388.2XP_016860877.1  tubulin monoglutamylase TTLL4 isoform X1

  7. XM_047446452.1XP_047302408.1  tubulin monoglutamylase TTLL4 isoform X2

    UniProtKB/Swiss-Prot
    Q8WW29
    UniProtKB/TrEMBL
    A0A024R424
  8. XM_017005387.2XP_016860876.1  tubulin monoglutamylase TTLL4 isoform X1

  9. XM_047446453.1XP_047302409.1  tubulin monoglutamylase TTLL4 isoform X2

    UniProtKB/Swiss-Prot
    Q8WW29
    UniProtKB/TrEMBL
    A0A024R424
  10. XM_017005390.2XP_016860879.1  tubulin monoglutamylase TTLL4 isoform X1

  11. XM_047446450.1XP_047302406.1  tubulin monoglutamylase TTLL4 isoform X2

    UniProtKB/Swiss-Prot
    Q8WW29
    UniProtKB/TrEMBL
    A0A024R424
  12. XM_017005391.2XP_016860880.1  tubulin monoglutamylase TTLL4 isoform X1

  13. XM_047446451.1XP_047302407.1  tubulin monoglutamylase TTLL4 isoform X2

    UniProtKB/Swiss-Prot
    Q8WW29
    UniProtKB/TrEMBL
    A0A024R424
    Related
    ENSP00000258398.4, ENST00000258398.8
  14. XM_047446459.1XP_047302415.1  tubulin monoglutamylase TTLL4 isoform X5

  15. XM_047446458.1XP_047302414.1  tubulin monoglutamylase TTLL4 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    219197391..219241970
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)