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Ttll4 tubulin tyrosine ligase-like family, member 4 [ Mus musculus (house mouse) ]

Gene ID: 67534, updated on 26-Sep-2022

Summary

Official Symbol
Ttll4provided by MGI
Official Full Name
tubulin tyrosine ligase-like family, member 4provided by MGI
Primary source
MGI:MGI:1914784
See related
Ensembl:ENSMUSG00000033257 AllianceGenome:MGI:1914784
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0173; 4632407P03Rik
Summary
Enables protein-glutamic acid ligase activity and tubulin binding activity. Involved in peptidyl-glutamic acid modification. Acts upstream of or within protein polyglutamylation and regulation of blastocyst development. Located in 9+0 non-motile cilium and ciliary basal body. Orthologous to human TTLL4 (tubulin tyrosine ligase like 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 16.4), CNS E11.5 (RPKM 10.3) and 27 other tissues See more
Orthologs
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Genomic context

See Ttll4 in Genome Data Viewer
Location:
1; 1 C4
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (74700804..74740991)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (74661645..74701832)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 25 Neighboring gene serine/threonine kinase 36 Neighboring gene cytochrome P450, family 27, subfamily a, polypeptide 1 Neighboring gene protein kinase, AMP-activated, gamma 3 non-catalytic subunit

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-glutamic acid ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables tubulin-glutamic acid ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables tubulin-glutamic acid ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in 9+0 non-motile cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tubulin monoglutamylase TTLL4; tubulin polyglutamylase TTLL4
Names
polyglutamylase
protein monoglutamylase TTLL4
tubulin--tyrosine ligase-like protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014974.2NP_001014974.1  tubulin monoglutamylase TTLL4

    See identical proteins and their annotated locations for NP_001014974.1

    Status: VALIDATED

    Source sequence(s)
    AC152409
    Consensus CDS
    CCDS15053.1
    UniProtKB/Swiss-Prot
    Q5U4C4, Q80UG8
    Related
    ENSMUSP00000037406.9, ENSMUST00000042125.15
    Conserved Domains (1) summary
    pfam03133
    Location:649941
    TTL; Tubulin-tyrosine ligase family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    74700804..74740991
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496224.3XP_006496287.1  tubulin polyglutamylase TTLL4 isoform X1

    See identical proteins and their annotated locations for XP_006496287.1

    UniProtKB/Swiss-Prot
    Q5U4C4, Q80UG8
    Conserved Domains (1) summary
    pfam03133
    Location:649941
    TTL; Tubulin-tyrosine ligase family
  2. XM_006496225.2XP_006496288.1  tubulin polyglutamylase TTLL4 isoform X1

    See identical proteins and their annotated locations for XP_006496288.1

    UniProtKB/Swiss-Prot
    Q5U4C4, Q80UG8
    Related
    ENSMUSP00000109308.2, ENSMUST00000113678.2
    Conserved Domains (1) summary
    pfam03133
    Location:649941
    TTL; Tubulin-tyrosine ligase family