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SH3PXD2A SH3 and PX domains 2A [ Homo sapiens (human) ]

Gene ID: 9644, updated on 8-Dec-2018

Summary

Official Symbol
SH3PXD2Aprovided by HGNC
Official Full Name
SH3 and PX domains 2Aprovided by HGNC
Primary source
HGNC:HGNC:23664
See related
Ensembl:ENSG00000107957
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FISH; TKS5; SH3MD1
Expression
Ubiquitous expression in endometrium (RPKM 4.2), ovary (RPKM 3.4) and 25 other tissues See more
Orthologs

Genomic context

See SH3PXD2A in Genome Data Viewer
Location:
10q24.33
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (103594027..103855406, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (105353784..105615195, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene NEURL1 antisense RNA 1 Neighboring gene calcium homeostasis modulator 3 Neighboring gene neuralized E3 ubiquitin protein ligase 1 Neighboring gene Sharpr-MPRA regulatory region 15000 Neighboring gene Sharpr-MPRA regulatory region 2777 Neighboring gene NFE2L2 motif-containing MPRA enhancer 292 Neighboring gene SH3PXD2A antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 190 Neighboring gene STN1, CST complex subunit Neighboring gene uncharacterized LOC102724351

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-3,4-bisphosphate binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-3-phosphate binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-4,5-bisphosphate binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-4-phosphate binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-5-phosphate binding IEA
Inferred from Electronic Annotation
more info
 
protease binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
superoxide-generating NADPH oxidase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
extracellular matrix organization TAS
Traceable Author Statement
more info
 
osteoclast fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
superoxide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
superoxide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
superoxide metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
podosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
SH3 and PX domain-containing protein 2A
Names
SH3 multiple domains 1
adapter protein TKS5
adaptor protein TKS5
five SH3 domain-containing protein
tyrosine kinase substrate with five SH3 domains

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001365079.1NP_001352008.1  SH3 and PX domain-containing protein 2A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK304828, AL121929
    Conserved Domains (6) summary
    cd12019
    Location:725777
    SH3_Tks5_4; Fourth Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12020
    Location:9571013
    SH3_Tks5_5; Fifth (C-terminal) Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12074
    Location:51103
    SH3_Tks5_1; First Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12077
    Location:150203
    SH3_Tks5_2; Second Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12079
    Location:332385
    SH3_Tks5_3; Third Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    TIGR04211
    Location:741826
    SH3_and_anchor; SH3 domain protein
  2. NM_014631.2NP_055446.2  SH3 and PX domain-containing protein 2A isoform 1

    See identical proteins and their annotated locations for NP_055446.2

    Status: VALIDATED

    Source sequence(s)
    AB007878, AK056469, AL121929, AL133355, BX647371, CN307901
    Consensus CDS
    CCDS31278.1
    UniProtKB/Swiss-Prot
    Q5TCZ1
    UniProtKB/TrEMBL
    B3KPL1
    Related
    ENSP00000348215.2, ENST00000355946.6
    Conserved Domains (6) summary
    cd06888
    Location:6124
    PX_FISH; The phosphoinositide binding Phox Homology domain of Five SH protein
    cd12019
    Location:816868
    SH3_Tks5_4; Fourth Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12020
    Location:10481104
    SH3_Tks5_5; Fifth (C-terminal) Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12074
    Location:170222
    SH3_Tks5_1; First Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12077
    Location:241294
    SH3_Tks5_2; Second Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains
    cd12079
    Location:423476
    SH3_Tks5_3; Third Src homology 3 domain of Tyrosine kinase substrate with five SH3 domains

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    103594027..103855406 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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