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SEC24C SEC24 homolog C, COPII coat complex component [ Homo sapiens (human) ]

Gene ID: 9632, updated on 7-Jan-2024

Summary

Official Symbol
SEC24Cprovided by HGNC
Official Full Name
SEC24 homolog C, COPII coat complex componentprovided by HGNC
Primary source
HGNC:HGNC:10705
See related
Ensembl:ENSG00000176986 MIM:607185; AllianceGenome:HGNC:10705
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The product of this gene may play a role in shaping the vesicle, as well as in cargo selection and concentration. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in esophagus (RPKM 30.5), thyroid (RPKM 29.8) and 25 other tissues See more
Orthologs
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Genomic context

See SEC24C in Genome Data Viewer
Location:
10q22.2
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (73744372..73772161)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (74615788..74643577)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (75504130..75531919)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:75491691-75492411 Neighboring gene glutamate dehydrogenase 1 pseudogene 3 Neighboring gene dual specificity phosphatase 8 pseudogene 5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:75500671-75501238 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:75501239-75501806 Neighboring gene uncharacterized LOC124902453 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:75503472-75504671 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3570 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3571 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2487 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:75532921-75533451 Neighboring gene fucosyltransferase 11 Neighboring gene uncharacterized LOC107984243 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3574

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0079

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables SNARE binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of COPII vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of COPII vesicle coat IDA
Inferred from Direct Assay
more info
PubMed 
part_of COPII vesicle coat NAS
Non-traceable Author Statement
more info
PubMed 
located_in ER to Golgi transport vesicle membrane TAS
Traceable Author Statement
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in endoplasmic reticulum exit site IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
protein transport protein Sec24C
Names
SEC24 family, member C
SEC24 related gene family, member C
SEC24-related protein C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004922.4NP_004913.2  protein transport protein Sec24C

    See identical proteins and their annotated locations for NP_004913.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC022400, AL596994, BQ710971, CA419040, D38555
    Consensus CDS
    CCDS7332.1
    UniProtKB/Swiss-Prot
    B4DZT4, P53992, Q8WV25
    UniProtKB/TrEMBL
    G5EA31
    Related
    ENSP00000343405.2, ENST00000339365.2
    Conserved Domains (9) summary
    COG5028
    Location:1811090
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
    cd01479
    Location:499758
    Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
    pfam00626
    Location:9611036
    Gelsolin; Gelsolin repeat
    pfam04810
    Location:422459
    zf-Sec23_Sec24; Sec23/Sec24 zinc finger
    pfam04815
    Location:847943
    Sec23_helical; Sec23/Sec24 helical domain
    pfam04959
    Location:221306
    ARS2; Arsenite-resistance protein 2
    pfam07001
    Location:142248
    BAT2_N; BAT2 N-terminus
    pfam08033
    Location:748831
    Sec23_BS; Sec23/Sec24 beta-sandwich domain
    pfam12764
    Location:11105
    Gly-rich_Ago1; Glycine-rich region of argonaut
  2. NM_198597.3NP_940999.1  protein transport protein Sec24C

    See identical proteins and their annotated locations for NP_940999.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a segment in the 5' UTR region, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC022400, AL596994, BC018928, CA419040, D38555
    Consensus CDS
    CCDS7332.1
    UniProtKB/Swiss-Prot
    B4DZT4, P53992, Q8WV25
    UniProtKB/TrEMBL
    G5EA31
    Related
    ENSP00000321845.6, ENST00000345254.9
    Conserved Domains (9) summary
    COG5028
    Location:1811090
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
    cd01479
    Location:499758
    Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
    pfam00626
    Location:9611036
    Gelsolin; Gelsolin repeat
    pfam04810
    Location:422459
    zf-Sec23_Sec24; Sec23/Sec24 zinc finger
    pfam04815
    Location:847943
    Sec23_helical; Sec23/Sec24 helical domain
    pfam04959
    Location:221306
    ARS2; Arsenite-resistance protein 2
    pfam07001
    Location:142248
    BAT2_N; BAT2 N-terminus
    pfam08033
    Location:748831
    Sec23_BS; Sec23/Sec24 beta-sandwich domain
    pfam12764
    Location:11105
    Gly-rich_Ago1; Glycine-rich region of argonaut

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    73744372..73772161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426032.1XP_047281988.1  protein transport protein Sec24C isoform X1

    UniProtKB/TrEMBL
    G5EA31
  2. XM_047426033.1XP_047281989.1  protein transport protein Sec24C isoform X2

    UniProtKB/Swiss-Prot
    B4DZT4, P53992, Q8WV25
    UniProtKB/TrEMBL
    G5EA31
  3. XM_047426031.1XP_047281987.1  protein transport protein Sec24C isoform X1

    UniProtKB/TrEMBL
    G5EA31
  4. XM_047426034.1XP_047281990.1  protein transport protein Sec24C isoform X2

    UniProtKB/Swiss-Prot
    B4DZT4, P53992, Q8WV25
    UniProtKB/TrEMBL
    G5EA31
  5. XM_011540381.4XP_011538683.1  protein transport protein Sec24C isoform X1

    See identical proteins and their annotated locations for XP_011538683.1

    UniProtKB/TrEMBL
    G5EA31
    Conserved Domains (8) summary
    COG5028
    Location:3231113
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
    cd01479
    Location:522781
    Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
    pfam00626
    Location:9841059
    Gelsolin; Gelsolin repeat
    pfam04810
    Location:445482
    zf-Sec23_Sec24; Sec23/Sec24 zinc finger
    pfam04815
    Location:870966
    Sec23_helical; Sec23/Sec24 helical domain
    pfam07001
    Location:142240
    BAT2_N; BAT2 N-terminus
    pfam08033
    Location:771854
    Sec23_BS; Sec23/Sec24 beta-sandwich domain
    pfam12764
    Location:11105
    Gly-rich_Ago1; Glycine-rich region of argonaut
  6. XM_011540380.4XP_011538682.1  protein transport protein Sec24C isoform X1

    See identical proteins and their annotated locations for XP_011538682.1

    UniProtKB/TrEMBL
    G5EA31
    Conserved Domains (8) summary
    COG5028
    Location:3231113
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
    cd01479
    Location:522781
    Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
    pfam00626
    Location:9841059
    Gelsolin; Gelsolin repeat
    pfam04810
    Location:445482
    zf-Sec23_Sec24; Sec23/Sec24 zinc finger
    pfam04815
    Location:870966
    Sec23_helical; Sec23/Sec24 helical domain
    pfam07001
    Location:142240
    BAT2_N; BAT2 N-terminus
    pfam08033
    Location:771854
    Sec23_BS; Sec23/Sec24 beta-sandwich domain
    pfam12764
    Location:11105
    Gly-rich_Ago1; Glycine-rich region of argonaut
  7. XM_047426035.1XP_047281991.1  protein transport protein Sec24C isoform X3

    UniProtKB/TrEMBL
    B4DSN3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    74615788..74643577
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367227.1XP_054223202.1  protein transport protein Sec24C isoform X1

    UniProtKB/TrEMBL
    G5EA31
  2. XM_054367226.1XP_054223201.1  protein transport protein Sec24C isoform X1

    UniProtKB/TrEMBL
    G5EA31
  3. XM_054367229.1XP_054223204.1  protein transport protein Sec24C isoform X2

    UniProtKB/Swiss-Prot
    B4DZT4, P53992, Q8WV25
    UniProtKB/TrEMBL
    G5EA31
  4. XM_054367230.1XP_054223205.1  protein transport protein Sec24C isoform X2

    UniProtKB/Swiss-Prot
    B4DZT4, P53992, Q8WV25
    UniProtKB/TrEMBL
    G5EA31
  5. XM_054367228.1XP_054223203.1  protein transport protein Sec24C isoform X1

    UniProtKB/TrEMBL
    G5EA31
  6. XM_054367231.1XP_054223206.1  protein transport protein Sec24C isoform X3

    UniProtKB/TrEMBL
    B4DSN3