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Sec24c SEC24 homolog C, COPII coat complex component [ Mus musculus (house mouse) ]

Gene ID: 218811, updated on 12-May-2024

Summary

Official Symbol
Sec24cprovided by MGI
Official Full Name
SEC24 homolog C, COPII coat complex componentprovided by MGI
Primary source
MGI:MGI:1919746
See related
Ensembl:ENSMUSG00000039367 AllianceGenome:MGI:1919746
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0079; 2610204K03Rik
Summary
Predicted to enable SNARE binding activity and zinc ion binding activity. Acts upstream of or within in utero embryonic development. Predicted to be located in cytosol. Predicted to be part of COPII vesicle coat. Predicted to be active in endoplasmic reticulum exit site. Is expressed in embryo and future spinal cord. Orthologous to human SEC24C (SEC24 homolog C, COPII coat complex component). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 52.7), large intestine adult (RPKM 44.2) and 28 other tissues See more
Orthologs
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Genomic context

See Sec24c in Genome Data Viewer
Location:
14 A3; 14 11.53 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (20722709..20744920)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (20674285..20694852)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene myozenin 1 Neighboring gene STARR-positive B cell enhancer ABC_E7297 Neighboring gene synaptopodin 2-like Neighboring gene STARR-seq mESC enhancer starr_36115 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:21501696-21501849 Neighboring gene microRNA 6946 Neighboring gene fucosyltransferase 11 Neighboring gene predicted gene, 25328

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables SNARE binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in COPII-coated vesicle cargo loading IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in COPII-coated vesicle cargo loading ISO
Inferred from Sequence Orthology
more info
 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of COPII vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of COPII vesicle coat ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum exit site IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
protein transport protein Sec24C
Names
Sec24 related gene family, member C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168273.1NP_001161745.1  protein transport protein Sec24C isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment and contains an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK036519, AK122199
    Consensus CDS
    CCDS88586.1
    UniProtKB/TrEMBL
    A0A286YDI8, Q80U83
    Related
    ENSMUSP00000153434.2, ENSMUST00000223751.2
    Conserved Domains (7) summary
    COG5028
    Location:801016
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
    cd01479
    Location:425684
    Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
    pfam00626
    Location:890962
    Gelsolin; Gelsolin repeat
    pfam04810
    Location:348385
    zf-Sec23_Sec24; Sec23/Sec24 zinc finger
    pfam04815
    Location:773869
    Sec23_helical; Sec23/Sec24 helical domain
    pfam08033
    Location:674757
    Sec23_BS; Sec23/Sec24 beta-sandwich domain
    pfam12764
    Location:11105
    Gly-rich_Ago1; Glycine-rich region of argonaut
  2. NM_172596.2NP_766184.2  protein transport protein Sec24C isoform 1

    See identical proteins and their annotated locations for NP_766184.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK036519, AK122199
    Consensus CDS
    CCDS26850.1
    UniProtKB/TrEMBL
    G3X972, Q8CGF4
    Related
    ENSMUSP00000045955.9, ENSMUST00000048657.10
    Conserved Domains (2) summary
    PHA03377
    Location:21224
    PHA03377; EBNA-3C; Provisional
    COG5028
    Location:1811092
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    20722709..20744920
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518813.2XP_006518876.1  protein transport protein Sec24C isoform X1

    See identical proteins and their annotated locations for XP_006518876.1

    UniProtKB/TrEMBL
    Q8CGF4
    Conserved Domains (2) summary
    COG5028
    Location:1811117
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
    pfam15449
    Location:12235
    Retinal; Retinal protein
  2. XM_006518817.2XP_006518880.1  protein transport protein Sec24C isoform X2

    UniProtKB/TrEMBL
    Q8CGF4
    Conserved Domains (2) summary
    COG5028
    Location:1811115
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
    pfam15449
    Location:12235
    Retinal; Retinal protein
  3. XM_036158551.1XP_036014444.1  protein transport protein Sec24C isoform X2

    UniProtKB/TrEMBL
    Q8CGF4
    Conserved Domains (2) summary
    COG5028
    Location:1811115
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
    pfam15449
    Location:12235
    Retinal; Retinal protein
  4. XM_030247745.2XP_030103605.1  protein transport protein Sec24C isoform X4

    UniProtKB/TrEMBL
    G3X972, Q8CGF4
    Conserved Domains (2) summary
    PHA03377
    Location:21224
    PHA03377; EBNA-3C; Provisional
    COG5028
    Location:1811092
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
  5. XM_006518816.3XP_006518879.1  protein transport protein Sec24C isoform X1

    See identical proteins and their annotated locations for XP_006518879.1

    UniProtKB/TrEMBL
    Q8CGF4
    Conserved Domains (2) summary
    COG5028
    Location:1811117
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
    pfam15449
    Location:12235
    Retinal; Retinal protein
  6. XM_006518815.3XP_006518878.1  protein transport protein Sec24C isoform X1

    See identical proteins and their annotated locations for XP_006518878.1

    UniProtKB/TrEMBL
    Q8CGF4
    Conserved Domains (2) summary
    COG5028
    Location:1811117
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
    pfam15449
    Location:12235
    Retinal; Retinal protein
  7. XM_030247743.2XP_030103603.1  protein transport protein Sec24C isoform X3

    UniProtKB/TrEMBL
    Q8CGF4
    Conserved Domains (2) summary
    COG5028
    Location:1811094
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
    pfam15449
    Location:12235
    Retinal; Retinal protein
  8. XM_036158550.1XP_036014443.1  protein transport protein Sec24C isoform X1

    UniProtKB/TrEMBL
    Q8CGF4
    Conserved Domains (2) summary
    COG5028
    Location:1811117
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
    pfam15449
    Location:12235
    Retinal; Retinal protein
  9. XM_036158552.1XP_036014445.1  protein transport protein Sec24C isoform X3

    UniProtKB/TrEMBL
    Q8CGF4
    Conserved Domains (2) summary
    COG5028
    Location:1811094
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
    pfam15449
    Location:12235
    Retinal; Retinal protein
  10. XM_006518818.3XP_006518881.1  protein transport protein Sec24C isoform X3

    UniProtKB/TrEMBL
    Q8CGF4
    Conserved Domains (2) summary
    COG5028
    Location:1811094
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
    pfam15449
    Location:12235
    Retinal; Retinal protein
  11. XM_030247744.2XP_030103604.1  protein transport protein Sec24C isoform X3

    UniProtKB/TrEMBL
    Q8CGF4
    Conserved Domains (2) summary
    COG5028
    Location:1811094
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
    pfam15449
    Location:12235
    Retinal; Retinal protein