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MTRF1 mitochondrial translation release factor 1 [ Homo sapiens (human) ]

Gene ID: 9617, updated on 2-Mar-2021

Summary

Official Symbol
MTRF1provided by HGNC
Official Full Name
mitochondrial translation release factor 1provided by HGNC
Primary source
HGNC:HGNC:7469
See related
Ensembl:ENSG00000120662 MIM:604601
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RF1; MRF1; MTTRF1
Summary
The protein encoded by this gene was determined by in silico methods to be a mitochondrial protein with similarity to the peptide chain release factors (RFs) discovered in bacteria and yeast. The peptide chain release factors direct the termination of translation in response to the peptide chain termination codons. Initially thought to have a role in the termination of mitochondria protein synthesis, a recent publication found no mitochondrial translation release functionality. Multiple alternatively spliced transcript variants have been suggested by mRNA and EST data; however, their full-length natures are not clear. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 2.7), lymph node (RPKM 2.2) and 25 other tissues See more
Orthologs
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Genomic context

See MTRF1 in Genome Data Viewer
Location:
13q14.11
Exon count:
21
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (41216369..41312038, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (41790505..41886174, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929140 Neighboring gene mortality factor 4 like 1 pseudogene 4 Neighboring gene kelch repeat and BTB domain containing 7 Neighboring gene uncharacterized LOC105370173 Neighboring gene Rac family small GTPase 1 pseudogene 3 Neighboring gene N-alpha-acetyltransferase 16, NatA auxiliary subunit Neighboring gene RNA, U6 small nuclear 57, pseudogene Neighboring gene tubulin beta pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC47721

Gene Ontology Provided by GOA

Function Evidence Code Pubs
translation release factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
mitochondrial translational termination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of translational termination TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
peptide chain release factor 1, mitochondrial
Names
MRF-1
mitochondrial translational release factor 1
mitochontrial peptide chain release factor 1
mtRF-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001354073.1NP_001341002.1  peptide chain release factor 1, mitochondrial

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein.
    Source sequence(s)
    AL354696
    Consensus CDS
    CCDS9378.1
    Conserved Domains (1) summary
    cl27687
    Location:79436
    RF-1; RF-1 domain
  2. NM_001354074.1NP_001341003.1  peptide chain release factor 1, mitochondrial

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AL354696
    Consensus CDS
    CCDS9378.1
    Conserved Domains (1) summary
    cl27687
    Location:79436
    RF-1; RF-1 domain
  3. NM_001354076.1NP_001341005.1  peptide chain release factor 1, mitochondrial

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AL354696
    Consensus CDS
    CCDS9378.1
    Conserved Domains (1) summary
    cl27687
    Location:79436
    RF-1; RF-1 domain
  4. NM_004294.4NP_004285.2  peptide chain release factor 1, mitochondrial

    See identical proteins and their annotated locations for NP_004285.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AL354696
    Consensus CDS
    CCDS9378.1
    UniProtKB/Swiss-Prot
    O75570
    UniProtKB/TrEMBL
    A0A024RDT1
    Related
    ENSP00000368793.3, ENST00000379480.9
    Conserved Domains (1) summary
    cl27687
    Location:79436
    RF-1; RF-1 domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    41216369..41312038 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020856.1XP_016876345.1  peptide chain release factor 1, mitochondrial isoform X1

    Conserved Domains (3) summary
    PRK00591
    Location:131488
    prfA; peptide chain release factor 1; Validated
    pfam00472
    Location:344449
    RF-1; RF-1 domain
    pfam03462
    Location:151334
    PCRF; PCRF domain
  2. XM_017020860.1XP_016876349.1  peptide chain release factor 1, mitochondrial isoform X3

    Conserved Domains (3) summary
    PRK00591
    Location:92449
    prfA; peptide chain release factor 1; Validated
    pfam00472
    Location:305410
    RF-1; RF-1 domain
    pfam03462
    Location:112295
    PCRF; PCRF domain
  3. XM_017020857.1XP_016876346.1  peptide chain release factor 1, mitochondrial isoform X1

    Conserved Domains (3) summary
    PRK00591
    Location:131488
    prfA; peptide chain release factor 1; Validated
    pfam00472
    Location:344449
    RF-1; RF-1 domain
    pfam03462
    Location:151334
    PCRF; PCRF domain
  4. XM_011535321.2XP_011533623.1  peptide chain release factor 1, mitochondrial isoform X5

    See identical proteins and their annotated locations for XP_011533623.1

    UniProtKB/Swiss-Prot
    O75570
    UniProtKB/TrEMBL
    A0A024RDT1
    Conserved Domains (1) summary
    cl27687
    Location:79436
    RF-1; RF-1 domain
  5. XM_017020875.1XP_016876364.1  peptide chain release factor 1, mitochondrial isoform X5

    UniProtKB/Swiss-Prot
    O75570
    UniProtKB/TrEMBL
    A0A024RDT1
    Conserved Domains (1) summary
    cl27687
    Location:79436
    RF-1; RF-1 domain
  6. XM_024449443.1XP_024305211.1  peptide chain release factor 1, mitochondrial isoform X5

    Conserved Domains (1) summary
    cl27687
    Location:79436
    RF-1; RF-1 domain
  7. XM_017020858.1XP_016876347.1  peptide chain release factor 1, mitochondrial isoform X1

    Conserved Domains (3) summary
    PRK00591
    Location:131488
    prfA; peptide chain release factor 1; Validated
    pfam00472
    Location:344449
    RF-1; RF-1 domain
    pfam03462
    Location:151334
    PCRF; PCRF domain
  8. XM_011535317.2XP_011533619.1  peptide chain release factor 1, mitochondrial isoform X3

    See identical proteins and their annotated locations for XP_011533619.1

    Conserved Domains (3) summary
    PRK00591
    Location:92449
    prfA; peptide chain release factor 1; Validated
    pfam00472
    Location:305410
    RF-1; RF-1 domain
    pfam03462
    Location:112295
    PCRF; PCRF domain
  9. XM_011535315.2XP_011533617.1  peptide chain release factor 1, mitochondrial isoform X1

    Conserved Domains (3) summary
    PRK00591
    Location:131488
    prfA; peptide chain release factor 1; Validated
    pfam00472
    Location:344449
    RF-1; RF-1 domain
    pfam03462
    Location:151334
    PCRF; PCRF domain
  10. XM_024449440.1XP_024305208.1  peptide chain release factor 1, mitochondrial isoform X5

    Conserved Domains (1) summary
    cl27687
    Location:79436
    RF-1; RF-1 domain
  11. XM_017020869.2XP_016876358.1  peptide chain release factor 1, mitochondrial isoform X5

    UniProtKB/Swiss-Prot
    O75570
    UniProtKB/TrEMBL
    A0A024RDT1
    Conserved Domains (1) summary
    cl27687
    Location:79436
    RF-1; RF-1 domain
  12. XM_006719900.2XP_006719963.1  peptide chain release factor 1, mitochondrial isoform X5

    See identical proteins and their annotated locations for XP_006719963.1

    UniProtKB/Swiss-Prot
    O75570
    UniProtKB/TrEMBL
    A0A024RDT1
    Conserved Domains (1) summary
    cl27687
    Location:79436
    RF-1; RF-1 domain
  13. XM_017020866.2XP_016876355.1  peptide chain release factor 1, mitochondrial isoform X5

    UniProtKB/Swiss-Prot
    O75570
    UniProtKB/TrEMBL
    A0A024RDT1
    Conserved Domains (1) summary
    cl27687
    Location:79436
    RF-1; RF-1 domain
  14. XM_017020865.2XP_016876354.1  peptide chain release factor 1, mitochondrial isoform X5

    UniProtKB/Swiss-Prot
    O75570
    UniProtKB/TrEMBL
    A0A024RDT1
    Conserved Domains (1) summary
    cl27687
    Location:79436
    RF-1; RF-1 domain
  15. XM_017020874.1XP_016876363.1  peptide chain release factor 1, mitochondrial isoform X5

    UniProtKB/Swiss-Prot
    O75570
    UniProtKB/TrEMBL
    A0A024RDT1
    Conserved Domains (1) summary
    cl27687
    Location:79436
    RF-1; RF-1 domain
  16. XM_011535323.2XP_011533625.1  peptide chain release factor 1, mitochondrial isoform X5

    See identical proteins and their annotated locations for XP_011533625.1

    UniProtKB/Swiss-Prot
    O75570
    UniProtKB/TrEMBL
    A0A024RDT1
    Conserved Domains (1) summary
    cl27687
    Location:79436
    RF-1; RF-1 domain
  17. XM_017020877.1XP_016876366.1  peptide chain release factor 1, mitochondrial isoform X10

  18. XM_011535318.3XP_011533620.1  peptide chain release factor 1, mitochondrial isoform X5

    See identical proteins and their annotated locations for XP_011533620.1

    UniProtKB/Swiss-Prot
    O75570
    UniProtKB/TrEMBL
    A0A024RDT1
    Conserved Domains (1) summary
    cl27687
    Location:79436
    RF-1; RF-1 domain
  19. XM_011535320.2XP_011533622.1  peptide chain release factor 1, mitochondrial isoform X5

    See identical proteins and their annotated locations for XP_011533622.1

    UniProtKB/Swiss-Prot
    O75570
    UniProtKB/TrEMBL
    A0A024RDT1
    Related
    ENSP00000368790.1, ENST00000379477.5
    Conserved Domains (1) summary
    cl27687
    Location:79436
    RF-1; RF-1 domain
  20. XM_011535325.2XP_011533627.1  peptide chain release factor 1, mitochondrial isoform X5

    See identical proteins and their annotated locations for XP_011533627.1

    UniProtKB/Swiss-Prot
    O75570
    UniProtKB/TrEMBL
    A0A024RDT1
    Conserved Domains (1) summary
    cl27687
    Location:79436
    RF-1; RF-1 domain
  21. XM_017020868.1XP_016876357.1  peptide chain release factor 1, mitochondrial isoform X5

    UniProtKB/Swiss-Prot
    O75570
    UniProtKB/TrEMBL
    A0A024RDT1
    Conserved Domains (1) summary
    cl27687
    Location:79436
    RF-1; RF-1 domain
  22. XM_006719898.2XP_006719961.1  peptide chain release factor 1, mitochondrial isoform X5

    See identical proteins and their annotated locations for XP_006719961.1

    UniProtKB/Swiss-Prot
    O75570
    UniProtKB/TrEMBL
    A0A024RDT1
    Conserved Domains (1) summary
    cl27687
    Location:79436
    RF-1; RF-1 domain
  23. XM_017020867.1XP_016876356.1  peptide chain release factor 1, mitochondrial isoform X5

    UniProtKB/Swiss-Prot
    O75570
    UniProtKB/TrEMBL
    A0A024RDT1
    Conserved Domains (1) summary
    cl27687
    Location:79436
    RF-1; RF-1 domain
  24. XM_024449442.1XP_024305210.1  peptide chain release factor 1, mitochondrial isoform X5

    Conserved Domains (1) summary
    cl27687
    Location:79436
    RF-1; RF-1 domain
  25. XM_024449441.1XP_024305209.1  peptide chain release factor 1, mitochondrial isoform X5

    Conserved Domains (1) summary
    cl27687
    Location:79436
    RF-1; RF-1 domain
  26. XM_017020861.2XP_016876350.1  peptide chain release factor 1, mitochondrial isoform X4

  27. XM_017020871.1XP_016876360.1  peptide chain release factor 1, mitochondrial isoform X6

  28. XM_017020859.2XP_016876348.1  peptide chain release factor 1, mitochondrial isoform X2

  29. XM_017020870.2XP_016876359.1  peptide chain release factor 1, mitochondrial isoform X6

  30. XM_024449444.1XP_024305212.1  peptide chain release factor 1, mitochondrial isoform X12

    Related
    ENSP00000399279.1, ENST00000452359.5
    Conserved Domains (1) summary
    cl23943
    Location:82234
    PCRF; PCRF domain
  31. XM_017020878.2XP_016876367.1  peptide chain release factor 1, mitochondrial isoform X11

  32. XM_011535326.3XP_011533628.1  peptide chain release factor 1, mitochondrial isoform X8

    Conserved Domains (2) summary
    pfam00472
    Location:344382
    RF-1; RF-1 domain
    pfam03462
    Location:151334
    PCRF; PCRF domain
  33. XM_017020872.1XP_016876361.1  peptide chain release factor 1, mitochondrial isoform X7

  34. XM_017020879.2XP_016876368.1  peptide chain release factor 1, mitochondrial isoform X12

    Conserved Domains (1) summary
    cl23943
    Location:82234
    PCRF; PCRF domain
  35. XM_011535327.2XP_011533629.1  peptide chain release factor 1, mitochondrial isoform X9

    Conserved Domains (1) summary
    pfam03462
    Location:151286
    PCRF; PCRF domain

RNA

  1. XR_001749743.1 RNA Sequence

  2. XR_001749742.2 RNA Sequence

  3. XR_002957484.1 RNA Sequence

  4. XR_001749744.2 RNA Sequence

  5. XR_001749741.1 RNA Sequence

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