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MINPP1 multiple inositol-polyphosphate phosphatase 1 [ Homo sapiens (human) ]

Gene ID: 9562, updated on 7-Jun-2020

Summary

Official Symbol
MINPP1provided by HGNC
Official Full Name
multiple inositol-polyphosphate phosphatase 1provided by HGNC
Primary source
HGNC:HGNC:7102
See related
Ensembl:ENSG00000107789 MIM:605391
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIPP; HIPER1; MINPP2
Summary
This gene encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This enzyme also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2,3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the glycolytic pathway.[provided by RefSeq, Sep 2009]
Expression
Ubiquitous expression in bone marrow (RPKM 5.4), adrenal (RPKM 4.7) and 25 other tissues See more
Orthologs

Genomic context

See MINPP1 in Genome Data Viewer
Location:
10q23.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (87504466..87553461)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (89264223..89313218)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268064 Neighboring gene CRISPRi-validated cis-regulatory element chr10.3228 Neighboring gene microRNA 4678 Neighboring gene uncharacterized LOC105378412 Neighboring gene ribosomal protein S26 pseudogene 38

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Follicular thyroid carcinoma
MedGen: C4225426 OMIM: 188470 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of multiple inositol-polyphosphate phosphatase 1 (MINPP1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp564L2016

Gene Ontology Provided by GOA

Process Evidence Code Pubs
bone mineralization NAS
Non-traceable Author Statement
more info
PubMed 
inositol phosphate metabolic process TAS
Traceable Author Statement
more info
 
ossification NAS
Non-traceable Author Statement
more info
PubMed 
polyphosphate metabolic process TAS
Traceable Author Statement
more info
PubMed 
protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 

General protein information

Preferred Names
multiple inositol polyphosphate phosphatase 1
Names
2,3-BPG phosphatase
2,3-bisphosphoglycerate 3-phosphatase
inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase
ins(1,3,4,5)P(4) 3-phosphatase
multiple inositol polyphosphate histidine phosphatase, 1
multiple inositol polyphosphate phosphatase 2
NP_001171588.1
NP_001171589.1
NP_004888.2
XP_006718141.1
XP_011538681.1
XP_016872454.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013023.1 RefSeqGene

    Range
    5428..53996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178117.1NP_001171588.1  multiple inositol polyphosphate phosphatase 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001171588.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate coding exons compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF084944, AL355334, AW243689
    Consensus CDS
    CCDS53551.1
    UniProtKB/Swiss-Prot
    Q9UNW1
    Related
    ENSP00000361062.4, ENST00000371994.8
    Conserved Domains (1) summary
    cl11399
    Location:82278
    HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
  2. NM_001178118.1NP_001171589.1  multiple inositol polyphosphate phosphatase 1 isoform 3

    See identical proteins and their annotated locations for NP_001171589.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK309176, AL355334, AW243689, BC032504
    Consensus CDS
    CCDS53552.1
    UniProtKB/Swiss-Prot
    Q9UNW1
    Related
    ENSP00000437823.1, ENST00000536010.1
    Conserved Domains (1) summary
    cd07061
    Location:78235
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
  3. NM_004897.5NP_004888.2  multiple inositol polyphosphate phosphatase 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_004888.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL355334, AW243689, BC032504
    Consensus CDS
    CCDS7384.1
    UniProtKB/Swiss-Prot
    Q9UNW1
    Related
    ENSP00000361064.4, ENST00000371996.9
    Conserved Domains (1) summary
    cd07061
    Location:82436
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    87504466..87553461
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718078.3XP_006718141.1  multiple inositol polyphosphate phosphatase 1 isoform X1

    Conserved Domains (1) summary
    cl11399
    Location:82310
    HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
  2. XM_017016965.2XP_016872454.1  multiple inositol polyphosphate phosphatase 1 isoform X2

  3. XM_011540379.3XP_011538681.1  multiple inositol polyphosphate phosphatase 1 isoform X3

    See identical proteins and their annotated locations for XP_011538681.1

    UniProtKB/Swiss-Prot
    Q9UNW1
    Conserved Domains (1) summary
    cd07061
    Location:78235
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
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