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SEC22B SEC22 homolog B, vesicle trafficking protein [ Homo sapiens (human) ]

Gene ID: 9554, updated on 7-Jun-2020

Summary

Official Symbol
SEC22Bprovided by HGNC
Official Full Name
SEC22 homolog B, vesicle trafficking proteinprovided by HGNC
Primary source
HGNC:HGNC:10700
See related
Ensembl:ENSG00000265808 MIM:604029
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERS-24; SEC22L1
Summary
The protein encoded by this gene is a member of the SEC22 family of vesicle trafficking proteins. It seems to complex with SNARE and it is thought to play a role in the ER-Golgi protein trafficking. This protein has strong similarity to Mus musculus and Cricetulus griseus proteins.[provided by RefSeq, Sep 2009]
Expression
Ubiquitous expression in thyroid (RPKM 13.3), fat (RPKM 13.0) and 25 other tissues See more
Orthologs

Genomic context

See SEC22B in Genome Data Viewer
Location:
1p12
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (120150898..120176520, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 (PATCHES) NW_003871056.3 (227516..248095, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378939 Neighboring gene uncharacterized LOC105378940 Neighboring gene RNA, U6 small nuclear 465, pseudogene Neighboring gene uncharacterized LOC100996723 Neighboring gene uncharacterized LOC107985522 Neighboring gene uncharacterized LOC105378941

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with SEC22B; predicted interaction to be within the endoplasmic reticulum to Golgi transport PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
syntaxin binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
COPI-coated vesicle IEA
Inferred from Electronic Annotation
more info
 
ER to Golgi transport vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ER to Golgi transport vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
ER to Golgi transport vesicle membrane TAS
Traceable Author Statement
more info
 
Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi membrane TAS
Traceable Author Statement
more info
 
SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum-Golgi intermediate compartment IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum-Golgi intermediate compartment membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
melanosome IEA
Inferred from Electronic Annotation
more info
 
phagocytic vesicle membrane TAS
Traceable Author Statement
more info
 
synaptic vesicle IEA
Inferred from Electronic Annotation
more info
 
transport vesicle TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
vesicle-trafficking protein SEC22b
Names
ER-Golgi SNARE of 24 kDa
SEC22 vesicle trafficking protein homolog B
SEC22 vesicle trafficking protein-like 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004892.6NP_004883.3  vesicle-trafficking protein SEC22b precursor

    See identical proteins and their annotated locations for NP_004883.3

    Status: REVIEWED

    Source sequence(s)
    AA135767, AC245008, AI085383, AK289875, BU741516, CD619408
    Consensus CDS
    CCDS83523.1
    UniProtKB/Swiss-Prot
    O75396
    Related
    ENSP00000463393.1, ENST00000578049.4
    Conserved Domains (2) summary
    cd15866
    Location:132195
    R-SNARE_SEC22; SNARE motif of SEC22
    cd14824
    Location:3126
    Longin; longin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    120150898..120176520 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002856.2XP_016858345.1  vesicle-trafficking protein SEC22b isoform X1

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