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BAG2 BAG cochaperone 2 [ Homo sapiens (human) ]

Gene ID: 9532, updated on 11-May-2025
Official Symbol
BAG2provided by HGNC
Official Full Name
BAG cochaperone 2provided by HGNC
Primary source
HGNC:HGNC:938
See related
Ensembl:ENSG00000112208 MIM:603882; AllianceGenome:HGNC:938
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BAG-2; dJ417I1.2
Summary
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]
Expression
Broad expression in endometrium (RPKM 20.1), urinary bladder (RPKM 13.7) and 21 other tissues See more
Orthologs
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See BAG2 in Genome Data Viewer
Location:
6p12.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (57172326..57189833)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (57011351..57028858)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (57037124..57054631)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:56912079-56912956 Neighboring gene KIAA1586 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:56954672-56955554 Neighboring gene ZNF451 regulatory antisense RNA 1 Neighboring gene zinc finger protein 451 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17302 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:57037271-57038028 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17304 Neighboring gene RAB23, member RAS oncogene family Neighboring gene DNA primase subunit 2 Neighboring gene long intergenic non-protein coding RNA 3001 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17305 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:57211753-57212253 Neighboring gene microRNA 548u

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • KIAA0576, MGC149462

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables adenyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables adenyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables adenyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
enables heat shock protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-folding chaperone binding IEA
Inferred from Electronic Annotation
more info
 
enables protein-folding chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tau protein binding IEA
Inferred from Electronic Annotation
more info
 
enables tau protein binding NAS
Non-traceable Author Statement
more info
PubMed 
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
colocalizes_with dendritic microtubule IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with dendritic microtubule ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
colocalizes_with microtubule IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with microtubule ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
part_of protein folding chaperone complex IPI
Inferred from Physical Interaction
more info
PubMed 
Preferred Names
BAG family molecular chaperone regulator 2
Names
BCL2 associated athanogene 2
bcl-2-associated athanogene 2
dJ417I1.2 (BAG-family molecular chaperone regulator 2)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004282.4NP_004273.1  BAG family molecular chaperone regulator 2

    See identical proteins and their annotated locations for NP_004273.1

    Status: REVIEWED

    Source sequence(s)
    AL031321, AL050287, AL136311, CA442969, DA874388
    Consensus CDS
    CCDS4961.1
    UniProtKB/Swiss-Prot
    B4DXE2, O95816, Q08AS9, Q6FID0
    UniProtKB/TrEMBL
    B3KM36, B3KN59
    Related
    ENSP00000359727.4, ENST00000370693.5
    Conserved Domains (1) summary
    smart00264
    Location:109189
    BAG; BAG domains, present in regulator of Hsp70 proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    57172326..57189833
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249490.5XP_005249547.1  BAG family molecular chaperone regulator 2 isoform X1

    See identical proteins and their annotated locations for XP_005249547.1

    UniProtKB/TrEMBL
    B3KM36, B3KN59
    Conserved Domains (1) summary
    smart00264
    Location:76156
    BAG; BAG domains, present in regulator of Hsp70 proteins
  2. XM_011514999.4XP_011513301.1  BAG family molecular chaperone regulator 2 isoform X1

    See identical proteins and their annotated locations for XP_011513301.1

    UniProtKB/TrEMBL
    B3KM36, B3KN59
    Conserved Domains (1) summary
    smart00264
    Location:76156
    BAG; BAG domains, present in regulator of Hsp70 proteins

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    57011351..57028858
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356854.1XP_054212829.1  BAG family molecular chaperone regulator 2 isoform X1

    UniProtKB/TrEMBL
    B3KM36, B3KN59
  2. XM_054356855.1XP_054212830.1  BAG family molecular chaperone regulator 2 isoform X1

    UniProtKB/TrEMBL
    B3KM36, B3KN59