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BAG2 BAG cochaperone 2 [ Homo sapiens (human) ]

Gene ID: 9532, updated on 6-Jul-2020

Summary

Official Symbol
BAG2provided by HGNC
Official Full Name
BAG cochaperone 2provided by HGNC
Primary source
HGNC:HGNC:938
See related
Ensembl:ENSG00000112208 MIM:603882
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BAG-2; dJ417I1.2
Summary
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]
Expression
Broad expression in endometrium (RPKM 20.1), urinary bladder (RPKM 13.7) and 21 other tissues See more
Orthologs

Genomic context

See BAG2 in Genome Data Viewer
Location:
6p12.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (57172326..57189833)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (57037104..57050013)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene KIAA1586 Neighboring gene ZNF451 regulatory antisense RNA 1 Neighboring gene zinc finger protein 451 Neighboring gene RAB23, member RAS oncogene family Neighboring gene uncharacterized LOC100506188 Neighboring gene DNA primase subunit 2 Neighboring gene microRNA 548u

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0576, MGC149462

Gene Ontology Provided by GOA

Function Evidence Code Pubs
adenyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
heat shock protein binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ion channel binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
tau protein binding NAS
Non-traceable Author Statement
more info
PubMed 
ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of proteasomal protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
NOT positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of protein processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein folding TAS
Traceable Author Statement
more info
PubMed 
protein metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
protein stabilization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein stabilization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cellular response to heat TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
axon ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
chaperone complex IPI
Inferred from Physical Interaction
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
colocalizes_with dendritic microtubule ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
colocalizes_with microtubule ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
BAG family molecular chaperone regulator 2
Names
BCL2 associated athanogene 2
bcl-2-associated athanogene 2
dJ417I1.2 (BAG-family molecular chaperone regulator 2)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004282.4NP_004273.1  BAG family molecular chaperone regulator 2

    See identical proteins and their annotated locations for NP_004273.1

    Status: REVIEWED

    Source sequence(s)
    AL031321, AL050287, AL136311, CA442969, DA874388
    Consensus CDS
    CCDS4961.1
    UniProtKB/Swiss-Prot
    O95816
    Related
    ENSP00000359727.4, ENST00000370693.5
    Conserved Domains (1) summary
    smart00264
    Location:109189
    BAG; BAG domains, present in regulator of Hsp70 proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    57172326..57189833
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514998.2XP_011513300.1  BAG family molecular chaperone regulator 2 isoform X1

    See identical proteins and their annotated locations for XP_011513300.1

    UniProtKB/Swiss-Prot
    O95816
    Conserved Domains (1) summary
    smart00264
    Location:76156
    BAG; BAG domains, present in regulator of Hsp70 proteins
  2. XM_024446593.1XP_024302361.1  BAG family molecular chaperone regulator 2 isoform X1

    Conserved Domains (1) summary
    smart00264
    Location:76156
    BAG; BAG domains, present in regulator of Hsp70 proteins
  3. XM_024446595.1XP_024302363.1  BAG family molecular chaperone regulator 2 isoform X1

    Conserved Domains (1) summary
    smart00264
    Location:76156
    BAG; BAG domains, present in regulator of Hsp70 proteins
  4. XM_024446594.1XP_024302362.1  BAG family molecular chaperone regulator 2 isoform X1

    Conserved Domains (1) summary
    smart00264
    Location:76156
    BAG; BAG domains, present in regulator of Hsp70 proteins
  5. XM_024446596.1XP_024302364.1  BAG family molecular chaperone regulator 2 isoform X1

    Conserved Domains (1) summary
    smart00264
    Location:76156
    BAG; BAG domains, present in regulator of Hsp70 proteins
  6. XM_005249490.4XP_005249547.1  BAG family molecular chaperone regulator 2 isoform X1

    See identical proteins and their annotated locations for XP_005249547.1

    UniProtKB/Swiss-Prot
    O95816
    Conserved Domains (1) summary
    smart00264
    Location:76156
    BAG; BAG domains, present in regulator of Hsp70 proteins
  7. XM_011514999.3XP_011513301.1  BAG family molecular chaperone regulator 2 isoform X1

    See identical proteins and their annotated locations for XP_011513301.1

    UniProtKB/Swiss-Prot
    O95816
    Conserved Domains (1) summary
    smart00264
    Location:76156
    BAG; BAG domains, present in regulator of Hsp70 proteins
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