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BAG2 BAG cochaperone 2 [ Homo sapiens (human) ]

Gene ID: 9532, updated on 7-Sep-2023

Summary

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Official Symbol
BAG2provided by HGNC
Official Full Name
BAG cochaperone 2provided by HGNC
Primary source
HGNC:HGNC:938
See related
Ensembl:ENSG00000112208 MIM:603882; AllianceGenome:HGNC:938
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BAG-2; dJ417I1.2
Summary
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]
Expression
Broad expression in endometrium (RPKM 20.1), urinary bladder (RPKM 13.7) and 21 other tissues See more
Orthologs
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Genomic context

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See BAG2 in Genome Data Viewer
Location:
6p12.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (57172326..57189833)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (57011351..57028858)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (57037124..57054631)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:56912079-56912956 Neighboring gene KIAA1586 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:56954672-56955554 Neighboring gene ZNF451 regulatory antisense RNA 1 Neighboring gene zinc finger protein 451 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:57037271-57038028 Neighboring gene RAB23, member RAS oncogene family Neighboring gene DNA primase subunit 2 Neighboring gene long intergenic non-protein coding RNA 3001 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:57211753-57212253 Neighboring gene microRNA 548u

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. BAG2 drives chemoresistance of breast cancer by exacerbating mutant p53 aggregate. Huang X, et al. Theranostics, 2023. PMID 36593950, Free PMC Article
  2. Bcl-2 Associated Athanogene 2 (BAG2) is Associated With Progression and Prognosis of Hepatocellular Carcinoma: A Bioinformatics-Based Analysis. Zhang X, et al. Pathol Oncol Res, 2021. PMID 34257542, Free PMC Article
  3. Over-expression of Bcl2-associated athanogene 2 in oral cancer promotes cellular proliferation and is associated with poor prognosis. Liu YS, et al. Arch Oral Biol, 2019 Jun. PMID 31055249
  4. Bag2 Is a Component of a Cytosolic Extraction Machinery That Promotes Membrane Penetration of a Nonenveloped Virus. Dupzyk A, et al. J Virol, 2018 Aug 1. PMID 29769335, Free PMC Article
  5. BAG2 structure, function and involvement in disease. Qin L, et al. Cell Mol Biol Lett, 2016. PMID 28536620, Free PMC Article

See all (224) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BAG2 drives chemoresistance of breast cancer by exacerbating mutant p53 aggregate.
    Title: BAG2 drives chemoresistance of breast cancer by exacerbating mutant p53 aggregate.
  2. BAG2 prevents Tau hyperphosphorylation and increases p62/SQSTM1 in cell models of neurodegeneration.
    Title: BAG2 prevents Tau hyperphosphorylation and increases p62/SQSTM1 in cell models of neurodegeneration.
  3. c-MYC-USP49-BAG2 axis promotes proliferation and chemoresistance of colorectal cancer cells in vitro.
    Title: c-MYC-USP49-BAG2 axis promotes proliferation and chemoresistance of colorectal cancer cells in vitro.
  4. Helicobacter pylori Targets in AGS Human Gastric Adenocarcinoma: In Situ Proteomic Profiling and Systematic Analysis.
    Title: Helicobacter pylori Targets in AGS Human Gastric Adenocarcinoma: In Situ Proteomic Profiling and Systematic Analysis.
  5. Bcl-2 Associated Athanogene 2 (BAG2) is Associated With Progression and Prognosis of Hepatocellular Carcinoma: A Bioinformatics-Based Analysis.
    Title: Bcl-2 Associated Athanogene 2 (BAG2) is Associated With Progression and Prognosis of Hepatocellular Carcinoma: A Bioinformatics-Based Analysis.
  6. Identification of BAG2 and Cathepsin D as Plasma Biomarkers for Parkinson's Disease.
    Title: Identification of BAG2 and Cathepsin D as Plasma Biomarkers for Parkinson's Disease.
  7. LOXL1 confers antiapoptosis and promotes gliomagenesis through stabilizing BAG2.
    Title: LOXL1 confers antiapoptosis and promotes gliomagenesis through stabilizing BAG2.
  8. High-regulated BAG2 is related to poor prognosis and could promote proliferation, invasion and migration of oral squamous cell carcinomas
    Title: Over-expression of Bcl2-associated athanogene 2 in oral cancer promotes cellular proliferation and is associated with poor prognosis.
  9. the nucleotide exchange factor (NEF) Bag2 stimulates SV40 release from Hsc70, thereby enabling successful virus arrival at the cytosol, which leads to infection. Hsp105, another NEF of Hsc70, displays a function overlapping that of Bag2, underscoring the importance of this release reaction.
    Title: Bag2 Is a Component of a Cytosolic Extraction Machinery That Promotes Membrane Penetration of a Nonenveloped Virus.
  10. A comprehensive review of the structure, functions, and protein interactions of BAG2
    Title: BAG2 structure, function and involvement in disease.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0576, MGC149462

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables adenyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables adenyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables heat shock protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-folding chaperone binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tau protein binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of proteasomal protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
NOT involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of protein processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein folding TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within protein metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein stabilization IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in protein stabilization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
colocalizes_with dendritic microtubule ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
colocalizes_with microtubule ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of protein folding chaperone complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
BAG family molecular chaperone regulator 2
Names
BCL2 associated athanogene 2
bcl-2-associated athanogene 2
dJ417I1.2 (BAG-family molecular chaperone regulator 2)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004282.4 → NP_004273.1  BAG family molecular chaperone regulator 2

    See identical proteins and their annotated locations for NP_004273.1

    Status: REVIEWED

    Source sequence(s)
    AL031321, AL050287, AL136311, CA442969, DA874388
    Consensus CDS
    CCDS4961.1
    UniProtKB/Swiss-Prot
    B4DXE2, O95816, Q08AS9, Q6FID0
    UniProtKB/TrEMBL
    B3KM36, B3KN59
    Related
    ENSP00000359727.4, ENST00000370693.5
    Conserved Domains (1) summary
    smart00264
    Location:109 → 189
    BAG; BAG domains, present in regulator of Hsp70 proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    57172326..57189833
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249490.5 → XP_005249547.1  BAG family molecular chaperone regulator 2 isoform X1

    See identical proteins and their annotated locations for XP_005249547.1

    UniProtKB/Swiss-Prot
    O95816
    UniProtKB/TrEMBL
    B3KM36, B3KN59
    Conserved Domains (1) summary
    smart00264
    Location:76 → 156
    BAG; BAG domains, present in regulator of Hsp70 proteins

  2. XM_011514999.4 → XP_011513301.1  BAG family molecular chaperone regulator 2 isoform X1

    See identical proteins and their annotated locations for XP_011513301.1

    UniProtKB/Swiss-Prot
    O95816
    UniProtKB/TrEMBL
    B3KM36, B3KN59
    Conserved Domains (1) summary
    smart00264
    Location:76 → 156
    BAG; BAG domains, present in regulator of Hsp70 proteins

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    57011351..57028858
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356854.1 → XP_054212829.1  BAG family molecular chaperone regulator 2 isoform X1

    UniProtKB/TrEMBL
    B3KM36, B3KN59

  2. XM_054356855.1 → XP_054212830.1  BAG family molecular chaperone regulator 2 isoform X1

    UniProtKB/TrEMBL
    B3KM36, B3KN59
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95816.1 GenPept UniProtKB/Swiss-Prot:O95816

Gene LinkOut

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