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BAG3 BAG cochaperone 3 [ Homo sapiens (human) ]

Gene ID: 9531, updated on 5-Dec-2021

Summary

Official Symbol
BAG3provided by HGNC
Official Full Name
BAG cochaperone 3provided by HGNC
Primary source
HGNC:HGNC:939
See related
Ensembl:ENSG00000151929 MIM:603883
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BIS; MFM6; BAG-3; CAIR-1
Summary
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in heart (RPKM 32.6), placenta (RPKM 26.6) and 25 other tissues See more
Orthologs
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Genomic context

See BAG3 in Genome Data Viewer
Location:
10q26.11
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (119651380..119677819)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (121410892..121437331)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene RAD1 pseudogene 1 Neighboring gene ribosomal protein S8 pseudogene 4 Neighboring gene thioredoxin pseudogene 1 Neighboring gene inositol polyphosphate-5-phosphatase F Neighboring gene RNA, 7SL, cytoplasmic 846, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy.
GeneReviews: Not available
Dilated cardiomyopathy 1HH Compare labs
Myofibrillar myopathy, BAG3-related
MedGen: C2751831 OMIM: 612954 GeneReviews: Not available
Compare labs
Primary dilated cardiomyopathy Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2015-02-12)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated 2015-02-12)

ClinGen Genome Curation PagePubMed

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the levels of BAG3 in human glioblastoma cells, and BAG3 silencing results in highly reducing Tat-induced upregulation of LC3-II and increasing the appearance of sub G0/G1 apoptotic cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC104307

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables adenyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables adenyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cadherin binding HDA PubMed 
enables chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables dynein intermediate chain binding NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein carrier chaperone TAS
Traceable Author Statement
more info
PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in aggresome assembly TAS
Traceable Author Statement
more info
PubMed 
involved_in autophagosome assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in brain development IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to heat IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to unfolded protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chaperone-mediated autophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors IDA
Inferred from Direct Assay
more info
PubMed 
involved_in muscle cell cellular homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in muscle cell cellular homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of protein targeting to mitochondrion IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of striated muscle cell apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of striated muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription from RNA polymerase II promoter in response to stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of aggrephagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein folding NAS
Non-traceable Author Statement
more info
PubMed 
involved_in protein stabilization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein stabilization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of protein transport along microtubule TAS
Traceable Author Statement
more info
PubMed 
involved_in spinal cord development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 
located_in aggresome TAS
Traceable Author Statement
more info
PubMed 
part_of chaperone complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
located_in stress fiber IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
BAG family molecular chaperone regulator 3
Names
BCL2 associated athanogene 3
BCL2-binding athanogene 3
Bcl-2-binding protein BIS transcript 2
bcl-2-binding protein Bis
docking protein CAIR-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016125.1 RefSeqGene

    Range
    5001..31450
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_742

mRNA and Protein(s)

  1. NM_004281.4NP_004272.2  BAG family molecular chaperone regulator 3

    See identical proteins and their annotated locations for NP_004272.2

    Status: REVIEWED

    Source sequence(s)
    AF071218, BC006418
    Consensus CDS
    CCDS7615.1
    UniProtKB/Swiss-Prot
    O95817
    Related
    ENSP00000358081.4, ENST00000369085.8
    Conserved Domains (2) summary
    smart00456
    Location:2153
    WW; Domain with 2 conserved Trp (W) residues
    smart00264
    Location:421498
    BAG; BAG domains, present in regulator of Hsp70 proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    119651380..119677819
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270287.2XP_005270344.1  BAG family molecular chaperone regulator 3 isoform X1

    Conserved Domains (2) summary
    smart00456
    Location:2153
    WW; Domain with 2 conserved Trp (W) residues
    smart00264
    Location:420497
    BAG; BAG domains, present in regulator of Hsp70 proteins
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