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TMEM59 transmembrane protein 59 [ Homo sapiens (human) ]

Gene ID: 9528, updated on 17-Jun-2019

Summary

Official Symbol
TMEM59provided by HGNC
Official Full Name
transmembrane protein 59provided by HGNC
Primary source
HGNC:HGNC:1239
See related
Ensembl:ENSG00000116209 MIM:617084
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DCF1; C1orf8; PRO195; UNQ169; HSPC001
Summary
This gene encodes a protein shown to regulate autophagy in response to bacterial infection. This protein may also regulate the retention of amyloid precursor protein (APP) in the Golgi apparatus through its control of APP glycosylation. Overexpression of this protein has been found to promote apoptosis in a glioma cell line. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Expression
Ubiquitous expression in colon (RPKM 47.8), prostate (RPKM 39.1) and 25 other tissues See more
Orthologs

Genomic context

See TMEM59 in Genome Data Viewer
Location:
1p32.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (54026681..54053573, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (54497346..54519135, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene 12 Neighboring gene low density lipoprotein receptor class A domain containing 1 Neighboring gene Sharpr-MPRA regulatory region 13762 Neighboring gene transcription elongation factor A N-terminal and central domain containing 2 Neighboring gene microRNA 4781 Neighboring gene cytochrome c oxidase subunit 7B pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14422, FLJ26177, FLJ33090, FLJ42977, FLJ90155

Gene Ontology Provided by GOA

Function Evidence Code Pubs
endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
autophagy IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein glycosylation in Golgi IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein processing IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi cis cisterna IDA
Inferred from Direct Assay
more info
PubMed 
Golgi medial cisterna IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
Golgi trans cisterna IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
late endosome IDA
Inferred from Direct Assay
more info
PubMed 
late endosome membrane IEA
Inferred from Electronic Annotation
more info
 
lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 
lysosome IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protein 59
Names
dendritic cell factor 1
liver membrane-bound protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305043.2NP_001291972.1  transmembrane protein 59 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001291972.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF290615, AK057652, AL353898, BC016374, CA776407
    UniProtKB/Swiss-Prot
    Q9BXS4
    UniProtKB/TrEMBL
    D3DQ48
    Conserved Domains (1) summary
    pfam12280
    Location:72257
    BSMAP; Brain specific membrane anchored protein
  2. NM_001305049.1NP_001291978.1  transmembrane protein 59 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001291978.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) includes an alternate 5' terminal exon resulting in a distinct 5' UTR and translation initiation at an in-frame downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AF290615, AK057652, AL353898, BP371330, BX463615, CA776407, DB459209
    UniProtKB/Swiss-Prot
    Q9BXS4
    Conserved Domains (1) summary
    pfam12280
    Location:1126
    BSMAP; Brain specific membrane anchored protein
  3. NM_001305050.2NP_001291979.1  transmembrane protein 59 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001291979.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons in the 5' coding region compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AF290615, AK057652, AL353898, BI604139, CA776407
    UniProtKB/Swiss-Prot
    Q9BXS4
    Conserved Domains (1) summary
    pfam12280
    Location:48190
    BSMAP; Brain specific membrane anchored protein
  4. NM_001305051.1NP_001291980.1  transmembrane protein 59 isoform 6 precursor

    See identical proteins and their annotated locations for NP_001291980.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) includes an alternate 5' terminal exon, uses an alternate splice site in its 5' coding region and initiates translation at an in-frame downstream start codon. The encoded isoform (6) is shorter than isoform 1. Variants 6 and 7 encode the same isoform (6).
    Source sequence(s)
    AF290615, AK057652, AL353898, BP371330, BU165003, CA776407, DB459209
    Consensus CDS
    CCDS81329.1
    UniProtKB/Swiss-Prot
    Q9BXS4
    UniProtKB/TrEMBL
    Q5T6Z8
    Related
    ENSP00000360392.1, ENST00000371341.5
    Conserved Domains (1) summary
    pfam12280
    Location:1125
    BSMAP; Brain specific membrane anchored protein
  5. NM_001305052.1NP_001291981.1  transmembrane protein 59 isoform 6 precursor

    See identical proteins and their annotated locations for NP_001291981.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) includes two alternate exons in its 5' UTR, uses an alternate splice site in its 5' coding region and initiates translation at an in-frame downstream start codon. The encoded isoform (6) is shorter than isoform 1. Variants 6 and 7 encode the same isoform (6).
    Source sequence(s)
    AF290615, AK057652, AL353898, BF574560, BP371330, CA776407, DB459209
    Consensus CDS
    CCDS81329.1
    UniProtKB/Swiss-Prot
    Q9BXS4
    UniProtKB/TrEMBL
    Q5T6Z8
    Related
    ENSP00000360395.1, ENST00000371344.5
    Conserved Domains (1) summary
    pfam12280
    Location:1125
    BSMAP; Brain specific membrane anchored protein
  6. NM_001305066.1NP_001291995.1  transmembrane protein 59 isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks several exons compared to variant 1 and its 3' terminal exon extends past a splice site that is used in variant 1. The encoded isoform (5) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AF290615, BM979433
    Consensus CDS
    CCDS81330.1
    UniProtKB/Swiss-Prot
    Q9BXS4
    UniProtKB/TrEMBL
    Q5T703
    Related
    ENSP00000360388.3, ENST00000371337.3
    Conserved Domains (1) summary
    pfam12280
    Location:72130
    BSMAP; Brain specific membrane anchored protein
  7. NM_004872.5NP_004863.2  transmembrane protein 59 isoform 2 precursor

    See identical proteins and their annotated locations for NP_004863.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is one amino acid shorter and includes a single amino acid substitution compared to isoform 1.
    Source sequence(s)
    AF290615, AK057652, AL353898, CA776407
    Consensus CDS
    CCDS586.1
    UniProtKB/Swiss-Prot
    Q9BXS4
    Related
    ENSP00000234831.5, ENST00000234831.9
    Conserved Domains (1) summary
    pfam12280
    Location:72256
    BSMAP; Brain specific membrane anchored protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    54026681..54053573 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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