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NPEPPS aminopeptidase puromycin sensitive [ Homo sapiens (human) ]

Gene ID: 9520, updated on 6-Jul-2025
Official Symbol
NPEPPSprovided by HGNC
Official Full Name
aminopeptidase puromycin sensitiveprovided by HGNC
Primary source
HGNC:HGNC:7900
See related
Ensembl:ENSG00000141279 MIM:606793; AllianceGenome:HGNC:7900
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSA; AAP-S; MP100
Summary
This gene encodes the puromycin-sensitive aminopeptidase, a zinc metallopeptidase which hydrolyzes amino acids from the N-terminus of its substrate. The protein has been localized to both the cytoplasm and to cellular membranes. This enzyme degrades enkaphalins in the brain, and studies in mouse suggest that it is involved in proteolytic events regulating the cell cycle. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in esophagus (RPKM 43.2), brain (RPKM 28.6) and 25 other tissues See more
Orthologs
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See NPEPPS in Genome Data Viewer
Location:
17q21.32
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (47522933..47623276)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (48385617..48485055)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (45600299..45700642)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene EF-hand calcium binding domain 13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8626 Neighboring gene nuclear factor, erythroid 2 like 3 pseudogene 2 Neighboring gene mitochondrial ribosomal protein L45 pseudogene 2 Neighboring gene MPRA-validated peak2874 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12312 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:45569915-45570430 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:45579384-45580583 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8627 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:45598943-45599444 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8628 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8629 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:45614024-45614225 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:45643631-45644132 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:45644133-45644632 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:45693347-45693848 Neighboring gene KPNB1 divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:45725440-45726285 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8630 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8631 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8632 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8633 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8634 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8635 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12313 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12314 Neighboring gene karyopherin subunit beta 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:45771282-45771962 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:45771963-45772642 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:45772643-45773323 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12315 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8638 Neighboring gene TBK1 binding protein 1

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EBI GWAS Catalog

Description
Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids.
EBI GWAS Catalog
No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis.
EBI GWAS Catalog

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human aminopeptidase puromycin sensitive (NPEPPS) at amino acid residues 677-678 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables alanyl aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables aminopeptidase activity EXP
Inferred from Experiment
more info
PubMed 
enables aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables aminopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables aminopeptidase activity TAS
Traceable Author Statement
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloaminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cellular response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of protein targeting to mitochondrion HMP PubMed 
involved_in protein polyubiquitination TAS
Traceable Author Statement
more info
 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
PubMed 
located_in extracellular exosome HDA PubMed 
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
puromycin-sensitive aminopeptidase
Names
cytosol alanyl aminopeptidase
metalloproteinase MP100
NP_001317186.1
NP_001398059.1
NP_006301.3
XP_016880862.1
XP_047293063.1
XP_047293064.1
XP_054173849.1
XP_054173850.1
XP_054173851.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330257.2NP_001317186.1  puromycin-sensitive aminopeptidase isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC025682, AJ132583, AK303037, AW662871
    Consensus CDS
    CCDS82149.1
    UniProtKB/TrEMBL
    B7Z899, E9PLK3
    Related
    ENSP00000433287.1, ENST00000530173.6
    Conserved Domains (3) summary
    cd09601
    Location:57500
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    pfam01433
    Location:49437
    Peptidase_M1; Peptidase family M1
    pfam11838
    Location:575886
    ERAP1_C; ERAP1-like C-terminal domain
  2. NM_001411130.1NP_001398059.1  puromycin-sensitive aminopeptidase isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC025682
    Consensus CDS
    CCDS92355.1
    UniProtKB/TrEMBL
    A0A7I2V3W8, B3KU93
    Related
    ENSP00000503738.1, ENST00000677370.1
  3. NM_006310.4NP_006301.3  puromycin-sensitive aminopeptidase isoform 1

    See identical proteins and their annotated locations for NP_006301.3

    Status: REVIEWED

    Source sequence(s)
    AJ132583, BC065294, BM723238, DB476543
    Consensus CDS
    CCDS45721.1
    UniProtKB/Swiss-Prot
    B7Z463, P55786, Q6P145, Q9NP16, Q9UEM2
    UniProtKB/TrEMBL
    B7Z899
    Related
    ENSP00000320324.4, ENST00000322157.9
    Conserved Domains (2) summary
    cd09601
    Location:61499
    M1_APN-Q_like; Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1)
    pfam11838
    Location:578891
    ERAP1_C; ERAP1-like C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    47522933..47623276
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025373.1XP_016880862.1  puromycin-sensitive aminopeptidase isoform X2

    UniProtKB/TrEMBL
    B7Z899
  2. XM_047437107.1XP_047293063.1  puromycin-sensitive aminopeptidase isoform X3

    UniProtKB/TrEMBL
    B3KU93
    Related
    ENST00000700499.1
  3. XM_047437108.1XP_047293064.1  puromycin-sensitive aminopeptidase isoform X1

    UniProtKB/TrEMBL
    B7Z1V9

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    48385617..48485055
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054317874.1XP_054173849.1  puromycin-sensitive aminopeptidase isoform X4

    UniProtKB/TrEMBL
    A0A7I2V389, B3KU93
  2. XM_054317875.1XP_054173850.1  puromycin-sensitive aminopeptidase isoform X5

    UniProtKB/TrEMBL
    B7Z4B2
  3. XM_054317876.1XP_054173851.1  puromycin-sensitive aminopeptidase isoform X1

    UniProtKB/TrEMBL
    B7Z1V9