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CD36 CD36 molecule [ Homo sapiens (human) ]

Gene ID: 948, updated on 19-Aug-2018

Summary

Official Symbol
CD36provided by HGNC
Official Full Name
CD36 moleculeprovided by HGNC
Primary source
HGNC:HGNC:1663
See related
Ensembl:ENSG00000135218 MIM:173510; Vega:OTTHUMG00000155383
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAT; GP4; GP3B; GPIV; CHDS7; PASIV; SCARB3; BDPLT10
Summary
The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014]
Expression
Biased expression in fat (RPKM 547.7), heart (RPKM 79.1) and 4 other tissues See more
Orthologs

Genomic context

See CD36 in Genome Data Viewer
Location:
7q21.11
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (80602188..80679277)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (80231504..80308593)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene small nuclear ribonucleoprotein polypeptides B and B1 pseudogene 1 Neighboring gene uncharacterized LOC107986812 Neighboring gene G protein subunit alpha transducin 3 Neighboring gene semaphorin 3C Neighboring gene HNF1 motif-containing MPRA enhancer 195

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Coronary heart disease 7
MedGen: C1970441 OMIM: 610938 GeneReviews: Not available
Compare labs
Platelet glycoprotein IV deficiency
MedGen: C1842090 OMIM: 608404 GeneReviews: Not available
Compare labs
Susceptibility to malaria
MedGen: C1970028 OMIM: 611162 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans.
NHGRI GWA Catalog
Genome-wide association study identifies single-nucleotide polymorphism in KCNB1 associated with left ventricular mass in humans: the HyperGEN Study.
NHGRI GWA Catalog
Genome-wide association study indicates variants associated with insulin signaling and inflammation mediate lipoprotein responses to fenofibrate.
NHGRI GWA Catalog
Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env CD36 co-localizes with HIV-1 Env in the cellular virus-containing compartments of macrophages PubMed
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of CD36 molecule (CD36; thrombospondin receptor) in peptide-treated PBMCs PubMed
Nef nef HIV-1 myristoylated Nef-induced TNF-alpha release leads to downregulation of CD36 expression by myristoylated Nef in monocyte-derived macrophages PubMed
nef HIV-1 myristoylated Nef downregulates CD36 expression in monocytes from PBMCs and monocyte-derived macrophages differentiated by cytokines. Nef-dependent downregulation of CD36 involves mRNA transcriptional inhibition PubMed
Pr55(Gag) gag CD36 co-localizes with HIV-1 Gag in the cellular virus-containing compartments and is required for efficient HIV-1 release by primary macrophages PubMed
capsid gag CD36 induces release of p24 in primary macrophages. Knockdown of CD36 by siRNA restricts the activity of CD36 PubMed
matrix gag Treatment of human PBMCs with HIV-1 MA upregulates the expression of MCP-1, ICAM-1, CD40, CD86 and CD36 and downregulates the expression of nuclear receptors FXR and PPARgamma PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • AMPK signaling pathway, organism-specific biosystem (from KEGG)
    AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • AMPK signaling pathway, conserved biosystem (from KEGG)
    AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • Activated TLR4 signalling, organism-specific biosystem (from REACTOME)
    Activated TLR4 signalling, organism-specific biosystemTLR4 is unique among the TLR family in its ability to recruit four adapters to activate two distinct signaling pathways. One pathway is activated by the pair of the adapters Mal or TIRAP (Toll/inter...
  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Adipocytokine signaling pathway, organism-specific biosystem (from KEGG)
    Adipocytokine signaling pathway, organism-specific biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
  • Adipocytokine signaling pathway, conserved biosystem (from KEGG)
    Adipocytokine signaling pathway, conserved biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
  • Antigen processing-Cross presentation, organism-specific biosystem (from REACTOME)
    Antigen processing-Cross presentation, organism-specific biosystemMHC class I molecules generally present peptide antigens derived from proteins synthesized by the cell itself to CD8+ T cells. However, in some circumstances, antigens from extracellular environment ...
  • Aryl Hydrocarbon Receptor, organism-specific biosystem (from WikiPathways)
    Aryl Hydrocarbon Receptor, organism-specific biosystemThe Aryl Hydrocarbon receptor (AhR) is ligand activated transcription factor that regulates wide spectrum of gene expression. The main mediator of AhR is 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) or...
  • Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystem (from REACTOME)
    Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystemScavenger receptors bind free extracellular ligands as the initial step in clearance of the ligands from the body (reviewed in Ascenzi et al. 2005, Areschoug and Gordon 2009, Nielsen et al. 2010). So...
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • Cross-presentation of particulate exogenous antigens (phagosomes), organism-specific biosystem (from REACTOME)
    Cross-presentation of particulate exogenous antigens (phagosomes), organism-specific biosystemDendritic cells (DCs) take up and process exogenous particulate or cell-associated antigens such as microbes or tumor cells for MHC-I cross-presentation. Particulate antigens have been reported to be...
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • Diseases associated with the TLR signaling cascade, organism-specific biosystem (from REACTOME)
    Diseases associated with the TLR signaling cascade, organism-specific biosystemToll like receptors (TLRs) are sensors of the innate immune system that detect danger signals derived from pathogens (pathogen-associated molecular patterns - PAMP) or damaged cells (damage-associate...
  • Diseases of Immune System, organism-specific biosystem (from REACTOME)
    Diseases of Immune System, organism-specific biosystemThe immune system is a complex network of the biological processes that provide defense mechanisms during infection or in response to an intrinsic danger signal. Compromised immune response may prese...
  • ECM-receptor interaction, organism-specific biosystem (from KEGG)
    ECM-receptor interaction, organism-specific biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
  • ECM-receptor interaction, conserved biosystem (from KEGG)
    ECM-receptor interaction, conserved biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
  • ER-Phagosome pathway, organism-specific biosystem (from REACTOME)
    ER-Phagosome pathway, organism-specific biosystemThe other TAP-dependent cross-presentation mechanism in phagocytes is the endoplasmic reticulum (ER)-phagosome model. Desjardins proposed that ER is recruited to the cell surface, where it fuses wit...
  • Fat digestion and absorption, organism-specific biosystem (from KEGG)
    Fat digestion and absorption, organism-specific biosystemFat is an important energy source from food. More than 95% of dietary fat is long-chain triacylglycerols (TAG), the remaining being phospholipids (4.5%) and sterols. In the small intestine lumen, die...
  • Fat digestion and absorption, conserved biosystem (from KEGG)
    Fat digestion and absorption, conserved biosystemFat is an important energy source from food. More than 95% of dietary fat is long-chain triacylglycerols (TAG), the remaining being phospholipids (4.5%) and sterols. In the small intestine lumen, die...
  • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
    Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
  • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
    Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Hematopoietic cell lineage, conserved biosystem (from KEGG)
    Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • IRAK4 deficiency (TLR2/4), organism-specific biosystem (from REACTOME)
    IRAK4 deficiency (TLR2/4), organism-specific biosystemInterleukin-1 receptor-associated kinase 4 (IRAK4) is a serine/threonine kinase, that mediates activation of transcriptional factors such as NFkB and AP1 downstream of IL-1 receptors and all toll lik...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Insulin resistance, organism-specific biosystem (from KEGG)
    Insulin resistance, organism-specific biosystemInsulin resistance is a condition where cells become resistant to the effects of insulin. It is often found in people with health disorders, including obesity, type 2 diabetes mellitus, non-alcoholic...
  • Interleukin-4 and 13 signaling, organism-specific biosystem (from REACTOME)
    Interleukin-4 and 13 signaling, organism-specific biosystemInterleukin-4 (IL4) is a principal regulatory cytokine during the immune response, crucially important in allergy and asthma (Nelms et al. 1999). When resting T cells are antigen-activated and expand...
  • Malaria, organism-specific biosystem (from KEGG)
    Malaria, organism-specific biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
  • Malaria, conserved biosystem (from KEGG)
    Malaria, conserved biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • MyD88 deficiency (TLR2/4), organism-specific biosystem (from REACTOME)
    MyD88 deficiency (TLR2/4), organism-specific biosystemMyeloid differentiation primary response (MyD88) is an adaptor protein that mediates intracellular signaling pathways evoked by all Toll-like receptors (TLRs) except for TLR3 and by several interleuk...
  • MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
    MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystemThe first known downstream component of TLR4 and TLR2 signaling is the adaptor MyD88. Another adapter MyD88-adaptor-like (Mal; also known as TIR-domain-containing adaptor protein or TIRAP) has also b...
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
  • PPAR signaling pathway, organism-specific biosystem (from KEGG)
    PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
  • PPAR signaling pathway, conserved biosystem (from KEGG)
    PPAR signaling pathway, conserved biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
  • PPARA activates gene expression, organism-specific biosystem (from REACTOME)
    PPARA activates gene expression, organism-specific biosystemThe set of genes regulated by PPAR-alpha is not fully known in humans, however many examples have been found in mice. Genes directly activated by PPAR-alpha contain peroxisome proliferator receptor e...
  • Phagosome, organism-specific biosystem (from KEGG)
    Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Phagosome, conserved biosystem (from KEGG)
    Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
    Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
  • Platelet degranulation, organism-specific biosystem (from REACTOME)
    Platelet degranulation, organism-specific biosystemPlatelets function as exocytotic cells, secreting a plethora of effector molecules at sites of vascular injury. Platelets contain a number of distinguishable storage granules including alpha granules...
  • Regulation of TLR by endogenous ligand, organism-specific biosystem (from REACTOME)
    Regulation of TLR by endogenous ligand, organism-specific biosystemDiverse molecules of host-cell origin may serve as endogenous ligands of Toll-like receptors (TLRs) (Erridge C 2010; Piccinini AM & Midwood KS 2010). These molecules are known as damage-associated mo...
  • Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
    Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemPeroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma ...
  • Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
    Response to elevated platelet cytosolic Ca2+, organism-specific biosystemActivation of phospholipase C enzymes results in the generation of second messengers of the phosphatidylinositol pathway. The events resulting from this pathway are a rise in intracellular calcium an...
  • Scavenging by Class B Receptors, organism-specific biosystem (from REACTOME)
    Scavenging by Class B Receptors, organism-specific biosystemClass B receptors have two transmembrane domains separated by an extracellular loop (reviewed in Adachi and Tsujimoto 2006, Areschoug and Gordon 2009).
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
  • Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystemTLR2 is involved in recognition of peptidoglycan from gram-positive bacteria, bacterial lipoproteins, mycoplasma lipoprotein and mycobacterial products. It is quite possible that recognition of at le...
  • Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystemToll-like Receptor 4 is a Microbe Associated Molecular Pattern receptor well known for it's sensitivity to Bacterial Lipopolysaccharides (LPS). LPS is assembled within diverse Gram-negative bacteria,...
  • Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystemTLR1 is expressed by monocytes. TLR1 and TLR2 cotranslationally form heterodimeric complexes on the cell surface and in the cytosol. The TLR2:TLR1 complex recognizes Neisserial PorB and Mycobacterial...
  • Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystemTLR2 and TLR4 recognize different bacterial cell wall components. While TLR4 is trained onto Gram-negative lipopolysaccharide components, TLR2 - in combination with TLR6 - plays a major role in recog...
  • Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
    Toll-Like Receptors Cascades, organism-specific biosystemIn human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) doma...
  • Transcriptional regulation of white adipocyte differentiation, organism-specific biosystem (from REACTOME)
    Transcriptional regulation of white adipocyte differentiation, organism-specific biosystemAdipogenesis is the process of cell differentiation by which preadipocytes become adipocytes. During this process the preadipocytes cease to proliferate, begin to accumulate lipid droplets and develo...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
  • Vitamin A and Carotenoid Metabolism, organism-specific biosystem (from WikiPathways)
    Vitamin A and Carotenoid Metabolism, organism-specific biosystemThis pathway is about carotenoid and vitamin A metabolism. The initial version was created by the NuGO focusteam on Carotenoid metabolism. It was used to test a text mining workflow which added some ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Toll-like receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
amyloid-beta binding TAS
Traceable Author Statement
more info
PubMed 
high-density lipoprotein particle binding IEA
Inferred from Electronic Annotation
more info
 
lipid binding IDA
Inferred from Direct Assay
more info
PubMed 
lipoprotein particle binding IDA
Inferred from Direct Assay
more info
PubMed 
lipoteichoic acid receptor activity IEA
Inferred from Electronic Annotation
more info
 
low-density lipoprotein particle binding IDA
Inferred from Direct Assay
more info
PubMed 
low-density lipoprotein particle receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
low-density lipoprotein particle receptor activity TAS
Traceable Author Statement
more info
PubMed 
oxidised low-density lipoprotein particle receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
scavenger receptor activity TAS
Traceable Author Statement
more info
PubMed 
thrombospondin receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
transforming growth factor beta binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
MyD88-dependent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
amyloid fibril formation ISS
Inferred from Sequence or Structural Similarity
more info
 
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
Traceable Author Statement
more info
 
apoptotic cell clearance IEA
Inferred from Electronic Annotation
more info
 
blood coagulation TAS
Traceable Author Statement
more info
PubMed 
cGMP-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cellular response to amyloid-beta IGI
Inferred from Genetic Interaction
more info
PubMed 
cellular response to diacyl bacterial lipopeptide IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to hydroperoxide IEA
Inferred from Electronic Annotation
more info
 
cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
cellular response to lipoteichoic acid IEA
Inferred from Electronic Annotation
more info
 
cellular response to low-density lipoprotein particle stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to oxidised low-density lipoprotein particle stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cholesterol import ISS
Inferred from Sequence or Structural Similarity
more info
 
cholesterol transport ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
defense response to Gram-positive bacterium IEA
Inferred from Electronic Annotation
more info
 
energy homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
interleukin-1 beta secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
intestinal absorption ISS
Inferred from Sequence or Structural Similarity
more info
 
intestinal cholesterol absorption ISS
Inferred from Sequence or Structural Similarity
more info
 
lipid metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
lipid storage IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipoprotein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipoprotein transport TAS
Traceable Author Statement
more info
PubMed 
long-chain fatty acid import IDA
Inferred from Direct Assay
more info
PubMed 
low-density lipoprotein particle clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
low-density lipoprotein particle mediated signaling IEA
Inferred from Electronic Annotation
more info
 
negative regulation of growth of symbiont in host IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
nitric oxide mediated signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
oxidised low-density lipoprotein particle clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
phagocytosis, recognition IEA
Inferred from Electronic Annotation
more info
 
plasma lipoprotein particle clearance ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
platelet degranulation TAS
Traceable Author Statement
more info
 
positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of NF-kappaB transcription factor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of NLRP3 inflammasome complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of blood coagulation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of blood microparticle formation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell-matrix adhesion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cholesterol storage IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of cytosolic calcium ion concentration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-12 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of macrophage cytokine production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of macrophage derived foam cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of nitric oxide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phagocytosis, engulfment IEA
Inferred from Electronic Annotation
more info
 
positive regulation of reactive oxygen species biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
 
receptor internalization ISS
Inferred from Sequence or Structural Similarity
more info
 
receptor-mediated endocytosis TAS
Traceable Author Statement
more info
 
regulation of lipid metabolic process TAS
Traceable Author Statement
more info
 
regulation of protein heterodimerization activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of removal of superoxide radicals IEA
Inferred from Electronic Annotation
more info
 
regulation of toll-like receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
response to fatty acid ISS
Inferred from Sequence or Structural Similarity
more info
 
response to linoleic acid ISS
Inferred from Sequence or Structural Similarity
more info
 
response to lipid ISS
Inferred from Sequence or Structural Similarity
more info
 
response to stilbenoid IEA
Inferred from Electronic Annotation
more info
 
sensory perception of taste ISS
Inferred from Sequence or Structural Similarity
more info
 
toll-like receptor TLR6:TLR2 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
triglyceride transport ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
brush border membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 
endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular space HDA PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
intracellular IPI
Inferred from Physical Interaction
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
phagocytic vesicle TAS
Traceable Author Statement
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
platelet alpha granule membrane TAS
Traceable Author Statement
more info
 
receptor complex IPI
Inferred from Physical Interaction
more info
PubMed 
specific granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
platelet glycoprotein 4
Names
CD36 antigen (collagen type I receptor, thrombospondin receptor)
CD36 molecule (thrombospondin receptor)
GPIIIB
PAS IV
PAS-4 protein
cluster determinant 36
fatty acid translocase
glycoprotein IIIb
leukocyte differentiation antigen CD36
platelet glycoprotein IV
scavenger receptor class B, member 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008192.1 RefSeqGene

    Range
    5001..77233
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000072.3NP_000063.2  platelet glycoprotein 4 isoform 1

    See identical proteins and their annotated locations for NP_000063.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (1). Variants 1 through 5 all encode the same isoform 1.
    Source sequence(s)
    AC124834, DA857400, DC338512, L06850, M98398
    Consensus CDS
    CCDS34673.1
    UniProtKB/Swiss-Prot
    P16671
    UniProtKB/TrEMBL
    A4D1B1
    Related
    ENSP00000378268.3, OTTHUMP00000207938, ENST00000394788.7, OTTHUMT00000339913
    Conserved Domains (1) summary
    pfam01130
    Location:16461
    CD36; CD36 family
  2. NM_001001547.2NP_001001547.1  platelet glycoprotein 4 isoform 1

    See identical proteins and their annotated locations for NP_001001547.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR exon, compared to variant 3. Variants 1 through 5 all encode the same isoform 1.
    Source sequence(s)
    BP258762, BP259746, L06850, M98398
    Consensus CDS
    CCDS34673.1
    UniProtKB/Swiss-Prot
    P16671
    UniProtKB/TrEMBL
    A4D1B1
    Related
    ENSP00000308165.7, OTTHUMP00000207874, ENST00000309881.11, OTTHUMT00000339772
    Conserved Domains (1) summary
    pfam01130
    Location:16461
    CD36; CD36 family
  3. NM_001001548.2NP_001001548.1  platelet glycoprotein 4 isoform 1

    See identical proteins and their annotated locations for NP_001001548.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has an alternate 3' UTR, compared to variant 3. Variants 1 through 5 all encode the same isoform 1.
    Source sequence(s)
    AC073850, AC124834, DA857400, DC338512, M98399
    Consensus CDS
    CCDS34673.1
    UniProtKB/Swiss-Prot
    P16671
    UniProtKB/TrEMBL
    A4D1B1
    Related
    ENSP00000415743.2, OTTHUMP00000207881, ENST00000447544.6, OTTHUMT00000339781
    Conserved Domains (1) summary
    pfam01130
    Location:16461
    CD36; CD36 family
  4. NM_001127443.1NP_001120915.1  platelet glycoprotein 4 isoform 1

    See identical proteins and their annotated locations for NP_001120915.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 3. Variants 1 through 5 all encode the same isoform 1.
    Source sequence(s)
    DA566475, L06850, M98398
    Consensus CDS
    CCDS34673.1
    UniProtKB/Swiss-Prot
    P16671
    UniProtKB/TrEMBL
    A4D1B1
    Related
    ENSP00000411411.1, ENST00000432207.5
    Conserved Domains (1) summary
    pfam01130
    Location:16461
    CD36; CD36 family
  5. NM_001127444.1NP_001120916.1  platelet glycoprotein 4 isoform 1

    See identical proteins and their annotated locations for NP_001120916.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 3. Variants 1 through 5 all encode the same isoform 1.
    Source sequence(s)
    AL596924, L06850, M98398
    Consensus CDS
    CCDS34673.1
    UniProtKB/Swiss-Prot
    P16671
    UniProtKB/TrEMBL
    A4D1B1
    Related
    ENSP00000392298.2, OTTHUMP00000207879, ENST00000419819.2, OTTHUMT00000339778
    Conserved Domains (1) summary
    pfam01130
    Location:16461
    CD36; CD36 family
  6. NM_001289908.1NP_001276837.1  platelet glycoprotein 4 isoform 2

    See identical proteins and their annotated locations for NP_001276837.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks two consecutive exons in the 3' coding region, compared to variant 3. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AK300101, HM217026, L06850
    Consensus CDS
    CCDS78249.1
    UniProtKB/Swiss-Prot
    P16671
    UniProtKB/TrEMBL
    B7Z6C3
    Related
    ENSP00000401863.2, ENST00000433696.6
    Conserved Domains (1) summary
    pfam01130
    Location:16422
    CD36; CD36 family
  7. NM_001289909.1NP_001276838.1  platelet glycoprotein 4 isoform 3

    See identical proteins and their annotated locations for NP_001276838.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks an in-frame coding exon, compared to variant 3. The resulting isoform (3) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AK300101, BC008406, HM217023, L06850
    Consensus CDS
    CCDS78250.1
    UniProtKB/Swiss-Prot
    P16671
    UniProtKB/TrEMBL
    B7Z6C3
    Related
    ENSP00000439543.1, ENST00000538969.5
    Conserved Domains (1) summary
    pfam01130
    Location:16401
    CD36; CD36 family
  8. NM_001289911.1NP_001276840.1  platelet glycoprotein 4 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) contains an alternate 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate downstream AUG, compared to variant 3. The resulting isoform (4) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK300101, AK312920, L06850
    Consensus CDS
    CCDS78251.1
    UniProtKB/Swiss-Prot
    P16671
    UniProtKB/TrEMBL
    A4D1B1, B7Z6C3, E9PLT1
    Related
    ENSP00000431296.1, OTTHUMP00000229733, ENST00000534394.5, OTTHUMT00000384027
    Conserved Domains (1) summary
    pfam01130
    Location:1385
    CD36; CD36 family

RNA

  1. NR_110501.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks an internal exon in the 3' region, compared to variant 3. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK300101, BC008406, HM217025, L06850
    Related
    ENST00000544133.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    80602188..80679277
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447003.1XP_024302771.1  platelet glycoprotein 4 isoform X1

    Conserved Domains (1) summary
    pfam01130
    Location:16461
    CD36; CD36 family
  2. XM_005250713.1XP_005250770.1  platelet glycoprotein 4 isoform X1

    See identical proteins and their annotated locations for XP_005250770.1

    UniProtKB/Swiss-Prot
    P16671
    UniProtKB/TrEMBL
    A4D1B1
    Conserved Domains (1) summary
    pfam01130
    Location:16461
    CD36; CD36 family
  3. XM_005250714.1XP_005250771.1  platelet glycoprotein 4 isoform X1

    See identical proteins and their annotated locations for XP_005250771.1

    UniProtKB/Swiss-Prot
    P16671
    UniProtKB/TrEMBL
    A4D1B1
    Conserved Domains (1) summary
    pfam01130
    Location:16461
    CD36; CD36 family
  4. XM_005250715.5XP_005250772.1  platelet glycoprotein 4 isoform X1

    See identical proteins and their annotated locations for XP_005250772.1

    UniProtKB/Swiss-Prot
    P16671
    UniProtKB/TrEMBL
    A4D1B1
    Conserved Domains (1) summary
    pfam01130
    Location:16461
    CD36; CD36 family
  5. XM_024447002.1XP_024302770.1  platelet glycoprotein 4 isoform X1

    Conserved Domains (1) summary
    pfam01130
    Location:16461
    CD36; CD36 family
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