Format

Send to:

Choose Destination

CD36 CD36 molecule [ Homo sapiens (human) ]

Gene ID: 948, updated on 28-Jun-2020

Summary

Official Symbol
CD36provided by HGNC
Official Full Name
CD36 moleculeprovided by HGNC
Primary source
HGNC:HGNC:1663
See related
Ensembl:ENSG00000135218 MIM:173510
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAT; GP4; GP3B; GPIV; CHDS7; PASIV; SCARB3; BDPLT10
Summary
The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014]
Expression
Biased expression in fat (RPKM 547.7), heart (RPKM 79.1) and 4 other tissues See more
Orthologs

Genomic context

See CD36 in Genome Data Viewer
Location:
7q21.11
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (80602207..80679277)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (80231504..80308593)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene small nuclear ribonucleoprotein polypeptides B and B1 pseudogene 1 Neighboring gene uncharacterized LOC107986812 Neighboring gene G protein subunit alpha transducin 3 Neighboring gene semaphorin 3C Neighboring gene HNF1 motif-containing MPRA enhancer 195

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Coronary heart disease 7
MedGen: C1970441 OMIM: 610938 GeneReviews: Not available
Compare labs
Platelet glycoprotein IV deficiency
MedGen: C1842090 OMIM: 608404 GeneReviews: Not available
Compare labs
Susceptibility to malaria
MedGen: C1970028 OMIM: 611162 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans.
NHGRI GWA Catalog
Genome-wide association study identifies single-nucleotide polymorphism in KCNB1 associated with left ventricular mass in humans: the HyperGEN Study.
NHGRI GWA Catalog
Genome-wide association study indicates variants associated with insulin signaling and inflammation mediate lipoprotein responses to fenofibrate.
NHGRI GWA Catalog
Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env CD36 co-localizes with HIV-1 Env in the cellular virus-containing compartments of macrophages PubMed
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of CD36 molecule (CD36; thrombospondin receptor) in peptide-treated PBMCs PubMed
Nef nef HIV-1 myristoylated Nef-induced TNF-alpha release leads to downregulation of CD36 expression by myristoylated Nef in monocyte-derived macrophages PubMed
nef HIV-1 myristoylated Nef downregulates CD36 expression in monocytes from PBMCs and monocyte-derived macrophages differentiated by cytokines. Nef-dependent downregulation of CD36 involves mRNA transcriptional inhibition PubMed
Pr55(Gag) gag CD36 co-localizes with HIV-1 Gag in the cellular virus-containing compartments and is required for efficient HIV-1 release by primary macrophages PubMed
capsid gag CD36 induces release of p24 in primary macrophages. Knockdown of CD36 by siRNA restricts the activity of CD36 PubMed
matrix gag Treatment of human PBMCs with HIV-1 MA upregulates the expression of MCP-1, ICAM-1, CD40, CD86 and CD36 and downregulates the expression of nuclear receptors FXR and PPARgamma PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Toll-like receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
amyloid-beta binding IC
Inferred by Curator
more info
PubMed 
amyloid-beta binding IDA
Inferred from Direct Assay
more info
PubMed 
amyloid-beta binding TAS
Traceable Author Statement
more info
PubMed 
high-density lipoprotein particle binding IEA
Inferred from Electronic Annotation
more info
 
lipid binding IDA
Inferred from Direct Assay
more info
PubMed 
lipoprotein particle binding IDA
Inferred from Direct Assay
more info
PubMed 
lipoteichoic acid receptor activity IEA
Inferred from Electronic Annotation
more info
 
long-chain fatty acid transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
low-density lipoprotein particle binding IDA
Inferred from Direct Assay
more info
PubMed 
low-density lipoprotein particle receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
low-density lipoprotein particle receptor activity TAS
Traceable Author Statement
more info
PubMed 
oxidised low-density lipoprotein particle receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
scavenger receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
scavenger receptor activity TAS
Traceable Author Statement
more info
PubMed 
short-chain fatty acid transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
thrombospondin receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
transforming growth factor beta binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
MyD88-dependent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
amyloid fibril formation ISS
Inferred from Sequence or Structural Similarity
more info
 
amyloid-beta clearance by cellular catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
Traceable Author Statement
more info
 
apoptotic cell clearance IEA
Inferred from Electronic Annotation
more info
 
blood coagulation TAS
Traceable Author Statement
more info
PubMed 
cGMP-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cellular response to amyloid-beta IGI
Inferred from Genetic Interaction
more info
PubMed 
cellular response to diacyl bacterial lipopeptide IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to hydroperoxide IEA
Inferred from Electronic Annotation
more info
 
cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
cellular response to lipoteichoic acid IEA
Inferred from Electronic Annotation
more info
 
cellular response to low-density lipoprotein particle stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to oxidised low-density lipoprotein particle stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cholesterol import ISS
Inferred from Sequence or Structural Similarity
more info
 
cholesterol transport ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
defense response to Gram-positive bacterium IEA
Inferred from Electronic Annotation
more info
 
energy homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
fatty acid metabolic process TAS
Traceable Author Statement
more info
PubMed 
interleukin-1 beta secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
intestinal absorption ISS
Inferred from Sequence or Structural Similarity
more info
 
intestinal cholesterol absorption ISS
Inferred from Sequence or Structural Similarity
more info
 
lipid metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
lipid storage IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipid transport across blood brain barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipoprotein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipoprotein transport TAS
Traceable Author Statement
more info
PubMed 
long-chain fatty acid import IDA
Inferred from Direct Assay
more info
PubMed 
long-chain fatty acid transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
low-density lipoprotein particle clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
low-density lipoprotein particle mediated signaling IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
nitric oxide mediated signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
oxidised low-density lipoprotein particle clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
phagocytosis, engulfment TAS
Traceable Author Statement
more info
PubMed 
phagocytosis, recognition IEA
Inferred from Electronic Annotation
more info
 
plasma lipoprotein particle clearance ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
platelet degranulation TAS
Traceable Author Statement
more info
 
positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of NF-kappaB transcription factor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of NLRP3 inflammasome complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of blood coagulation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of blood microparticle formation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell-matrix adhesion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cholesterol storage IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of cytosolic calcium ion concentration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-12 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of macrophage cytokine production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of macrophage derived foam cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of nitric oxide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phagocytosis, engulfment IEA
Inferred from Electronic Annotation
more info
 
positive regulation of reactive oxygen species biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
 
production of molecular mediator involved in inflammatory response TAS
Traceable Author Statement
more info
PubMed 
receptor internalization ISS
Inferred from Sequence or Structural Similarity
more info
 
receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
receptor-mediated endocytosis TAS
Traceable Author Statement
more info
 
regulation of action potential ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of lipid metabolic process TAS
Traceable Author Statement
more info
 
regulation of lipopolysaccharide-mediated signaling pathway TAS
Traceable Author Statement
more info
PubMed 
regulation of protein complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of removal of superoxide radicals IEA
Inferred from Electronic Annotation
more info
 
regulation of toll-like receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
response to fatty acid ISS
Inferred from Sequence or Structural Similarity
more info
 
response to linoleic acid ISS
Inferred from Sequence or Structural Similarity
more info
 
response to lipid ISS
Inferred from Sequence or Structural Similarity
more info
 
response to stilbenoid IEA
Inferred from Electronic Annotation
more info
 
sensory perception of taste ISS
Inferred from Sequence or Structural Similarity
more info
 
short-chain fatty acid transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
toll-like receptor TLR6:TLR2 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
triglyceride transport ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
brush border membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 
cell surface TAS
Traceable Author Statement
more info
PubMed 
endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular space HDA PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
phagocytic vesicle TAS
Traceable Author Statement
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
platelet alpha granule membrane TAS
Traceable Author Statement
more info
 
receptor complex IPI
Inferred from Physical Interaction
more info
PubMed 
specific granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
platelet glycoprotein 4
Names
CD36 antigen (collagen type I receptor, thrombospondin receptor)
CD36 molecule (thrombospondin receptor)
GPIIIB
PAS IV
PAS-4 protein
cluster determinant 36
fatty acid translocase
glycoprotein IIIb
leukocyte differentiation antigen CD36
platelet glycoprotein IV
scavenger receptor class B, member 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008192.1 RefSeqGene

    Range
    5020..77233
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000072.3NP_000063.2  platelet glycoprotein 4 isoform 1

    See identical proteins and their annotated locations for NP_000063.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (1). Variants 1-5 and 10-13 all encode the same isoform (1).
    Source sequence(s)
    AC124834, DA857400, DC338512, L06850, M98398
    Consensus CDS
    CCDS34673.1
    UniProtKB/Swiss-Prot
    P16671
    UniProtKB/TrEMBL
    A4D1B1
    Related
    ENSP00000378268.3, ENST00000394788.7
    Conserved Domains (1) summary
    pfam01130
    Location:16461
    CD36; CD36 family
  2. NM_001001547.3NP_001001547.1  platelet glycoprotein 4 isoform 1

    See identical proteins and their annotated locations for NP_001001547.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR exon, compared to variant 3. Variants 1-5 and 10-13 all encode the same isoform (1).
    Source sequence(s)
    BP258762, BP259746, L06850, M98398
    Consensus CDS
    CCDS34673.1
    UniProtKB/Swiss-Prot
    P16671
    UniProtKB/TrEMBL
    A4D1B1
    Related
    ENSP00000308165.7, ENST00000309881.11
    Conserved Domains (1) summary
    pfam01130
    Location:16461
    CD36; CD36 family
  3. NM_001001548.2NP_001001548.1  platelet glycoprotein 4 isoform 1

    See identical proteins and their annotated locations for NP_001001548.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has an alternate 3' UTR, compared to variant 3. Variants 1-5 and 10-13 all encode the same isoform (1).
    Source sequence(s)
    AC073850, AC124834, DA857400, DC338512, M98399
    Consensus CDS
    CCDS34673.1
    UniProtKB/Swiss-Prot
    P16671
    UniProtKB/TrEMBL
    A4D1B1
    Related
    ENSP00000415743.2, ENST00000447544.7
    Conserved Domains (1) summary
    pfam01130
    Location:16461
    CD36; CD36 family
  4. NM_001127443.1NP_001120915.1  platelet glycoprotein 4 isoform 1

    See identical proteins and their annotated locations for NP_001120915.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 3. Variants 1-5 and 10-13 all encode the same isoform (1).
    Source sequence(s)
    DA566475, L06850, M98398
    Consensus CDS
    CCDS34673.1
    UniProtKB/Swiss-Prot
    P16671
    UniProtKB/TrEMBL
    A4D1B1
    Related
    ENSP00000411411.1, ENST00000432207.5
    Conserved Domains (1) summary
    pfam01130
    Location:16461
    CD36; CD36 family
  5. NM_001127444.2NP_001120916.1  platelet glycoprotein 4 isoform 1

    See identical proteins and their annotated locations for NP_001120916.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 3. Variants 1-5 and 10-13 all encode the same isoform (1).
    Source sequence(s)
    AL596924, L06850, M98398
    Consensus CDS
    CCDS34673.1
    UniProtKB/Swiss-Prot
    P16671
    UniProtKB/TrEMBL
    A4D1B1
    Related
    ENSP00000392298.2, ENST00000419819.2
    Conserved Domains (1) summary
    pfam01130
    Location:16461
    CD36; CD36 family
  6. NM_001289908.1NP_001276837.1  platelet glycoprotein 4 isoform 2

    See identical proteins and their annotated locations for NP_001276837.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks two consecutive exons in the 3' coding region, compared to variant 3. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AK300101, HM217026, L06850
    Consensus CDS
    CCDS78249.1
    UniProtKB/Swiss-Prot
    P16671
    UniProtKB/TrEMBL
    B7Z6C3
    Related
    ENSP00000401863.2, ENST00000433696.6
    Conserved Domains (1) summary
    pfam01130
    Location:16422
    CD36; CD36 family
  7. NM_001289909.1NP_001276838.1  platelet glycoprotein 4 isoform 3

    See identical proteins and their annotated locations for NP_001276838.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks an in-frame coding exon, compared to variant 3. The resulting isoform (3) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AK300101, BC008406, HM217023, L06850
    Consensus CDS
    CCDS78250.1
    UniProtKB/Swiss-Prot
    P16671
    UniProtKB/TrEMBL
    B7Z6C3
    Related
    ENSP00000439543.1, ENST00000538969.5
    Conserved Domains (1) summary
    pfam01130
    Location:16401
    CD36; CD36 family
  8. NM_001289911.2NP_001276840.1  platelet glycoprotein 4 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) contains an alternate 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate downstream AUG, compared to variant 3. The resulting isoform (4) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK300101, AK312920, L06850
    Consensus CDS
    CCDS78251.1
    UniProtKB/Swiss-Prot
    P16671
    UniProtKB/TrEMBL
    A4D1B1, B7Z6C3, E9PLT1
    Related
    ENSP00000431296.1, ENST00000534394.5
    Conserved Domains (1) summary
    pfam01130
    Location:1385
    CD36; CD36 family
  9. NM_001371074.1NP_001358003.1  platelet glycoprotein 4 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 1-5 and 11-13, encodes isoform 1.
    Source sequence(s)
    AC073182, AC073850
  10. NM_001371075.1NP_001358004.1  platelet glycoprotein 4 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variants 1-5, 10, 12, and 13, encodes isoform 1.
    Source sequence(s)
    AC073182, AC073850
  11. NM_001371077.1NP_001358006.1  platelet glycoprotein 4 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 1-5, 10, 11, and 13, encodes isoform 1.
    Source sequence(s)
    AC073850, AC124834
  12. NM_001371078.1NP_001358007.1  platelet glycoprotein 4 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 1-5 and 10-12, encodes isoform 1.
    Source sequence(s)
    AC073850, AC124834
    Related
    ENSP00000399421.1, ENST00000435819.5
  13. NM_001371079.1NP_001358008.1  platelet glycoprotein 4 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC073850, AC124834
  14. NM_001371080.1NP_001358009.1  platelet glycoprotein 4 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variant 16, encodes isoform 6.
    Source sequence(s)
    AC073182, AC073850
  15. NM_001371081.1NP_001358010.1  platelet glycoprotein 4 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variant 15, encodes isoform 6.
    Source sequence(s)
    AC073182, AC073850

RNA

  1. NR_110501.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks an internal exon in the 3' region, compared to variant 3. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK300101, BC008406, HM217025, L06850
    Related
    ENST00000544133.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    80602207..80679277
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447003.1XP_024302771.1  platelet glycoprotein 4 isoform X1

    Conserved Domains (1) summary
    pfam01130
    Location:16461
    CD36; CD36 family
  2. XM_005250715.5XP_005250772.1  platelet glycoprotein 4 isoform X1

    See identical proteins and their annotated locations for XP_005250772.1

    UniProtKB/Swiss-Prot
    P16671
    UniProtKB/TrEMBL
    A4D1B1
    Conserved Domains (1) summary
    pfam01130
    Location:16461
    CD36; CD36 family
  3. XM_024447002.1XP_024302770.1  platelet glycoprotein 4 isoform X1

    Conserved Domains (1) summary
    pfam01130
    Location:16461
    CD36; CD36 family
Support Center