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CD36 CD36 molecule [ Homo sapiens (human) ]

Gene ID: 948, updated on 5-Jan-2022

Summary

Official Symbol
CD36provided by HGNC
Official Full Name
CD36 moleculeprovided by HGNC
Primary source
HGNC:HGNC:1663
See related
Ensembl:ENSG00000135218 MIM:173510
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAT; GP4; GP3B; GPIV; CHDS7; PASIV; SCARB3; BDPLT10
Summary
The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014]
Expression
Biased expression in fat (RPKM 547.7), heart (RPKM 79.1) and 4 other tissues See more
Orthologs
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Genomic context

See CD36 in Genome Data Viewer
Location:
7q21.11
Exon count:
19
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (80602207..80679277)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (80231523..80308593)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 1340 Neighboring gene uncharacterized LOC107986812 Neighboring gene G protein subunit alpha transducin 3 Neighboring gene semaphorin 3C Neighboring gene HNF1 motif-containing MPRA enhancer 195

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Coronary heart disease 7
MedGen: C1970441 OMIM: 610938 GeneReviews: Not available
Compare labs
Platelet glycoprotein IV deficiency
MedGen: C1842090 OMIM: 608404 GeneReviews: Not available
Compare labs
Susceptibility to malaria
MedGen: C1970028 OMIM: 611162 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans.
EBI GWAS Catalog
Genome-wide association study identifies single-nucleotide polymorphism in KCNB1 associated with left ventricular mass in humans: the HyperGEN Study.
EBI GWAS Catalog
Genome-wide association study indicates variants associated with insulin signaling and inflammation mediate lipoprotein responses to fenofibrate.
EBI GWAS Catalog
Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env CD36 co-localizes with HIV-1 Env in the cellular virus-containing compartments of macrophages PubMed
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of CD36 molecule (CD36; thrombospondin receptor) in peptide-treated PBMCs PubMed
Nef nef HIV-1 myristoylated Nef-induced TNF-alpha release leads to downregulation of CD36 expression by myristoylated Nef in monocyte-derived macrophages PubMed
nef HIV-1 myristoylated Nef downregulates CD36 expression in monocytes from PBMCs and monocyte-derived macrophages differentiated by cytokines. Nef-dependent downregulation of CD36 involves mRNA transcriptional inhibition PubMed
Pr55(Gag) gag CD36 co-localizes with HIV-1 Gag in the cellular virus-containing compartments and is required for efficient HIV-1 release by primary macrophages PubMed
capsid gag CD36 induces release of p24 in primary macrophages. Knockdown of CD36 by siRNA restricts the activity of CD36 PubMed
matrix gag Treatment of human PBMCs with HIV-1 MA upregulates the expression of MCP-1, ICAM-1, CD40, CD86 and CD36 and downregulates the expression of nuclear receptors FXR and PPARgamma PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Toll-like receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables amyloid-beta binding IC
Inferred by Curator
more info
PubMed 
enables amyloid-beta binding IDA
Inferred from Direct Assay
more info
PubMed 
enables amyloid-beta binding TAS
Traceable Author Statement
more info
PubMed 
enables high-density lipoprotein particle binding IEA
Inferred from Electronic Annotation
more info
 
enables lipid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables lipoprotein particle binding IDA
Inferred from Direct Assay
more info
PubMed 
enables lipoteichoic acid immune receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables long-chain fatty acid transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables long-chain fatty acid transporter activity TAS
Traceable Author Statement
more info
 
enables low-density lipoprotein particle binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables low-density lipoprotein particle binding IDA
Inferred from Direct Assay
more info
PubMed 
enables low-density lipoprotein particle receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables low-density lipoprotein particle receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables low-density lipoprotein particle receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables oleate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables oxidised low-density lipoprotein particle receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables scavenger receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables scavenger receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables scavenger receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables short-chain fatty acid transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables thrombospondin receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables transforming growth factor beta binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in amyloid fibril formation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in amyloid-beta clearance by cellular catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in amyloid-beta clearance by cellular catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apoptotic cell clearance IEA
Inferred from Electronic Annotation
more info
 
involved_in blood coagulation TAS
Traceable Author Statement
more info
PubMed 
involved_in cGMP-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to amyloid-beta IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to diacyl bacterial lipopeptide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to hydroperoxide IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to lipoteichoic acid IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to low-density lipoprotein particle stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to oxidised low-density lipoprotein particle stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cholesterol import ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cholesterol transport ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in defense response to Gram-positive bacterium IEA
Inferred from Electronic Annotation
more info
 
involved_in energy homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in fatty acid metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in intestinal absorption ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in intestinal cholesterol absorption ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in lipid metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in lipid storage IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lipid storage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipid transport across blood-brain barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipoprotein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lipoprotein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipoprotein transport TAS
Traceable Author Statement
more info
PubMed 
involved_in long-chain fatty acid import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in long-chain fatty acid import into cell IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in long-chain fatty acid import into cell IDA
Inferred from Direct Assay
more info
PubMed 
involved_in long-chain fatty acid transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in low-density lipoprotein particle clearance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in low-density lipoprotein particle clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in low-density lipoprotein particle mediated signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in nitric oxide mediated signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in oxidised low-density lipoprotein particle clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phagocytosis, engulfment TAS
Traceable Author Statement
more info
PubMed 
involved_in phagocytosis, recognition IEA
Inferred from Electronic Annotation
more info
 
involved_in plasma lipoprotein particle clearance ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of NLRP3 inflammasome complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of blood coagulation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of blood microparticle formation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell-matrix adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cholesterol storage IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of interleukin-1 beta production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of interleukin-12 production IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of macrophage cytokine production IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of macrophage derived foam cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of nitric oxide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of phagocytosis, engulfment IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of reactive oxygen species biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
 
involved_in production of molecular mediator involved in inflammatory response TAS
Traceable Author Statement
more info
PubMed 
involved_in receptor internalization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in receptor-mediated endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of action potential ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of lipopolysaccharide-mediated signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of removal of superoxide radicals IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of toll-like receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to fatty acid ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to linoleic acid ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to lipid ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to stilbenoid IEA
Inferred from Electronic Annotation
more info
 
involved_in sensory perception of taste ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in short-chain fatty acid transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in triglyceride transport ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in brush border membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in caveola IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cell surface TAS
Traceable Author Statement
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 
located_in integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in phagocytic vesicle TAS
Traceable Author Statement
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in platelet alpha granule membrane TAS
Traceable Author Statement
more info
 
part_of receptor complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in specific granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
platelet glycoprotein 4
Names
CD36 antigen (collagen type I receptor, thrombospondin receptor)
CD36 molecule (thrombospondin receptor)
GPIIIB
PAS IV
PAS-4 protein
cluster determinant 36
fatty acid translocase
glycoprotein IIIb
leukocyte differentiation antigen CD36
platelet glycoprotein IV
scavenger receptor class B, member 3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008192.1 RefSeqGene

    Range
    5020..77233
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000072.3NP_000063.2  platelet glycoprotein 4 isoform 1

    See identical proteins and their annotated locations for NP_000063.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (1). Variants 1-5 and 10-13 all encode the same isoform (1).
    Source sequence(s)
    AC124834, DA857400, DC338512, L06850, M98398
    Consensus CDS
    CCDS34673.1
    UniProtKB/Swiss-Prot
    P16671
    UniProtKB/TrEMBL
    A4D1B1
    Related
    ENSP00000378268.3, ENST00000394788.7
    Conserved Domains (1) summary
    pfam01130
    Location:14463
    CD36; CD36 family
  2. NM_001001547.3NP_001001547.1  platelet glycoprotein 4 isoform 1

    See identical proteins and their annotated locations for NP_001001547.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR exon, compared to variant 3. Variants 1-5 and 10-13 all encode the same isoform (1).
    Source sequence(s)
    BP258762, BP259746, L06850, M98398
    Consensus CDS
    CCDS34673.1
    UniProtKB/Swiss-Prot
    P16671
    UniProtKB/TrEMBL
    A4D1B1
    Related
    ENSP00000308165.7, ENST00000309881.11
    Conserved Domains (1) summary
    pfam01130
    Location:14463
    CD36; CD36 family
  3. NM_001001548.3NP_001001548.1  platelet glycoprotein 4 isoform 1

    See identical proteins and their annotated locations for NP_001001548.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has an alternate 3' UTR, compared to variant 3. Variants 1-5 and 10-13 all encode the same isoform (1).
    Source sequence(s)
    AC073850, AC124834
    Consensus CDS
    CCDS34673.1
    UniProtKB/Swiss-Prot
    P16671
    UniProtKB/TrEMBL
    A4D1B1
    Related
    ENSP00000415743.2, ENST00000447544.7
    Conserved Domains (1) summary
    pfam01130
    Location:14463
    CD36; CD36 family
  4. NM_001127443.2NP_001120915.1  platelet glycoprotein 4 isoform 1

    See identical proteins and their annotated locations for NP_001120915.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 3. Variants 1-5 and 10-13 all encode the same isoform (1).
    Source sequence(s)
    AC073850, DA566475, L06850, M98398
    Consensus CDS
    CCDS34673.1
    UniProtKB/Swiss-Prot
    P16671
    UniProtKB/TrEMBL
    A4D1B1
    Related
    ENSP00000411411.1, ENST00000432207.5
    Conserved Domains (1) summary
    pfam01130
    Location:14463
    CD36; CD36 family
  5. NM_001127444.2NP_001120916.1  platelet glycoprotein 4 isoform 1

    See identical proteins and their annotated locations for NP_001120916.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 3. Variants 1-5 and 10-13 all encode the same isoform (1).
    Source sequence(s)
    AL596924, L06850, M98398
    Consensus CDS
    CCDS34673.1
    UniProtKB/Swiss-Prot
    P16671
    UniProtKB/TrEMBL
    A4D1B1
    Related
    ENSP00000392298.2, ENST00000419819.2
    Conserved Domains (1) summary
    pfam01130
    Location:14463
    CD36; CD36 family
  6. NM_001289908.1NP_001276837.1  platelet glycoprotein 4 isoform 2

    See identical proteins and their annotated locations for NP_001276837.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks two consecutive exons in the 3' coding region, compared to variant 3. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AK300101, HM217026, L06850
    Consensus CDS
    CCDS78249.1
    UniProtKB/Swiss-Prot
    P16671
    UniProtKB/TrEMBL
    B7Z6C3
    Related
    ENSP00000401863.2, ENST00000433696.6
    Conserved Domains (1) summary
    pfam01130
    Location:16422
    CD36; CD36 family
  7. NM_001289909.1NP_001276838.1  platelet glycoprotein 4 isoform 3

    See identical proteins and their annotated locations for NP_001276838.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks an in-frame coding exon, compared to variant 3. The resulting isoform (3) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AK300101, BC008406, HM217023, L06850
    Consensus CDS
    CCDS78250.1
    UniProtKB/Swiss-Prot
    P16671
    UniProtKB/TrEMBL
    B7Z6C3
    Related
    ENSP00000439543.1, ENST00000538969.5
    Conserved Domains (1) summary
    pfam01130
    Location:16401
    CD36; CD36 family
  8. NM_001289911.2NP_001276840.1  platelet glycoprotein 4 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) contains an alternate 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate downstream AUG, compared to variant 3. The resulting isoform (4) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK300101, AK312920, L06850
    Consensus CDS
    CCDS78251.1
    UniProtKB/Swiss-Prot
    P16671
    UniProtKB/TrEMBL
    A4D1B1, B7Z6C3, E9PLT1
    Related
    ENSP00000431296.1, ENST00000534394.5
    Conserved Domains (1) summary
    pfam01130
    Location:1385
    CD36; CD36 family
  9. NM_001371074.1NP_001358003.1  platelet glycoprotein 4 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 1-5 and 11-13, encodes isoform 1.
    Source sequence(s)
    AC073182, AC073850
    Conserved Domains (1) summary
    pfam01130
    Location:14463
    CD36; CD36 family
  10. NM_001371075.1NP_001358004.1  platelet glycoprotein 4 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variants 1-5, 10, 12, and 13, encodes isoform 1.
    Source sequence(s)
    AC073182, AC073850
    Conserved Domains (1) summary
    pfam01130
    Location:14463
    CD36; CD36 family
  11. NM_001371077.1NP_001358006.1  platelet glycoprotein 4 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 1-5, 10, 11, and 13, encodes isoform 1.
    Source sequence(s)
    AC073850, AC124834
    Conserved Domains (1) summary
    pfam01130
    Location:14463
    CD36; CD36 family
  12. NM_001371078.1NP_001358007.1  platelet glycoprotein 4 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 1-5 and 10-12, encodes isoform 1.
    Source sequence(s)
    AC073850, AC124834
    Related
    ENSP00000399421.1, ENST00000435819.5
    Conserved Domains (1) summary
    pfam01130
    Location:14463
    CD36; CD36 family
  13. NM_001371079.1NP_001358008.1  platelet glycoprotein 4 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC073850, AC124834
    Conserved Domains (1) summary
    pfam01130
    Location:16429
    CD36; CD36 family
  14. NM_001371080.1NP_001358009.1  platelet glycoprotein 4 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variant 16, encodes isoform 6.
    Source sequence(s)
    AC073182, AC073850
    Conserved Domains (1) summary
    pfam01130
    Location:1308
    CD36; CD36 family
  15. NM_001371081.1NP_001358010.1  platelet glycoprotein 4 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variant 15, encodes isoform 6.
    Source sequence(s)
    AC073182, AC073850
    Conserved Domains (1) summary
    pfam01130
    Location:1308
    CD36; CD36 family

RNA

  1. NR_110501.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks an internal exon in the 3' region, compared to variant 3. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK300101, BC008406, HM217025, L06850
    Related
    ENST00000544133.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    80602207..80679277
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447003.1XP_024302771.1  platelet glycoprotein 4 isoform X1

    Conserved Domains (1) summary
    pfam01130
    Location:14463
    CD36; CD36 family
  2. XM_005250715.5XP_005250772.1  platelet glycoprotein 4 isoform X1

    See identical proteins and their annotated locations for XP_005250772.1

    UniProtKB/Swiss-Prot
    P16671
    UniProtKB/TrEMBL
    A4D1B1
    Conserved Domains (1) summary
    pfam01130
    Location:14463
    CD36; CD36 family
  3. XM_024447002.1XP_024302770.1  platelet glycoprotein 4 isoform X1

    Conserved Domains (1) summary
    pfam01130
    Location:14463
    CD36; CD36 family
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