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NAPSA napsin A aspartic peptidase [ Homo sapiens (human) ]

Gene ID: 9476, updated on 3-Jun-2018
Official Symbol
NAPSAprovided by HGNC
Official Full Name
napsin A aspartic peptidaseprovided by HGNC
Primary source
HGNC:HGNC:13395
See related
Ensembl:ENSG00000131400 MIM:605631; Vega:OTTHUMG00000183035
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KAP; Kdap; NAP1; NAPA; SNAPA
Summary
This gene encodes a member of the peptidase A1 family of aspartic proteases. The encoded preproprotein is proteolytically processed to generate an activation peptide and the mature protease. The activation peptides of aspartic proteinases function as inhibitors of the protease active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The encoded protease may play a role in the proteolytic processing of pulmonary surfactant protein B in the lung and may function in protein catabolism in the renal proximal tubules. This gene has been described as a marker for lung adenocarcinoma and renal cell carcinoma. [provided by RefSeq, Feb 2016]
Expression
Restricted expression toward lung (RPKM 393.9) See more
Orthologs
See NAPSA in Genome Data Viewer
Location:
19q13.33
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (50358472..50369331, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50861734..50868931, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily C member 3 Neighboring gene Sharpr-MPRA regulatory region 11330/13384 Neighboring gene uncharacterized LOC105372437 Neighboring gene napsin B aspartic peptidase, pseudogene Neighboring gene nuclear receptor subfamily 1 group H member 2 Neighboring gene DNA polymerase delta 1, catalytic subunit

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Lysosome, organism-specific biosystem (from KEGG)
    Lysosome, organism-specific biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
  • Lysosome, conserved biosystem (from KEGG)
    Lysosome, conserved biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Surfactant metabolism, organism-specific biosystem (from REACTOME)
    Surfactant metabolism, organism-specific biosystemThe alveolar region of the lung creates an extensive epithelial surface that mediates the transfer of oxygen and carbon dioxide required for respiration after birth. Type I epithelial cells form the ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
aspartic-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
aspartic-type endopeptidase activity NAS
Non-traceable Author Statement
more info
PubMed 
endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
peptidase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
membrane protein proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteolysis NAS
Non-traceable Author Statement
more info
PubMed 
surfactant homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
alveolar lamellar body IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
lysosome IDA
Inferred from Direct Assay
more info
PubMed 
multivesicular body lumen TAS
Traceable Author Statement
more info
 
Preferred Names
napsin-A
Names
ASP4
TA01/TA02
asp 4
aspartyl protease 4
kidney-derived aspartic protease-like protein
napsin-1
pronapsin A

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004851.2NP_004842.1  napsin-A preproprotein

    See identical proteins and their annotated locations for NP_004842.1

    Status: REVIEWED

    Source sequence(s)
    AF098484, BI770845, BM971610
    Consensus CDS
    CCDS12794.1
    UniProtKB/Swiss-Prot
    O96009
    Related
    ENSP00000253719.1, OTTHUMP00000270671, ENST00000253719.6, OTTHUMT00000464714
    Conserved Domains (2) summary
    pfam00026
    Location:77401
    Asp; Eukaryotic aspartyl protease
    cl11403
    Location:72399
    pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    50358472..50369331 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027512.1XP_016883001.1  napsin-A isoform X2

  2. XM_011527540.1XP_011525842.1  napsin-A isoform X1

    See identical proteins and their annotated locations for XP_011525842.1

    UniProtKB/Swiss-Prot
    O96009
    Conserved Domains (2) summary
    pfam00026
    Location:77401
    Asp; Eukaryotic aspartyl protease
    cl11403
    Location:72399
    pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases
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