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Napsa napsin A aspartic peptidase [ Mus musculus (house mouse) ]

Gene ID: 16541, updated on 23-May-2018
Official Symbol
Napsaprovided by MGI
Official Full Name
napsin A aspartic peptidaseprovided by MGI
Primary source
MGI:MGI:109365
See related
Ensembl:ENSMUSG00000002204 Vega:OTTMUSG00000021117
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KAP; Kdap; NAP1; SNAPA; pronapsin
Expression
Biased expression in kidney adult (RPKM 2223.2) and lung adult (RPKM 258.7) See more
Orthologs
See Napsa in Genome Data Viewer
Location:
7; 7 B3
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (44572445..44586846)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (51827815..51842216)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene polymerase (DNA directed), delta 1, catalytic subunit Neighboring gene microRNA 7053 Neighboring gene nuclear receptor subfamily 1, group H, member 2 Neighboring gene predicted gene 15396 Neighboring gene predicted gene, 45981 Neighboring gene potassium voltage gated channel, Shaw-related subfamily, member 3

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a
  • Lysosome, organism-specific biosystem (from KEGG)
    Lysosome, organism-specific biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
  • Lysosome, conserved biosystem (from KEGG)
    Lysosome, conserved biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Surfactant metabolism, organism-specific biosystem (from REACTOME)
    Surfactant metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
aspartic-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
peptidase activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
membrane protein proteolysis IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane protein proteolysis ISO
Inferred from Sequence Orthology
more info
 
proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
surfactant homeostasis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
alveolar lamellar body IDA
Inferred from Direct Assay
more info
PubMed 
alveolar lamellar body ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
lysosome IDA
Inferred from Direct Assay
more info
PubMed 
lysosome ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
napsin-A
Names
KDAP-1
kidney-derived aspartic protease-like protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008437.1NP_032463.1  napsin-A precursor

    See identical proteins and their annotated locations for NP_032463.1

    Status: VALIDATED

    Source sequence(s)
    D88899
    Consensus CDS
    CCDS21212.1
    UniProtKB/Swiss-Prot
    O09043
    UniProtKB/TrEMBL
    Q3U7H1
    Related
    ENSMUSP00000002274.8, OTTMUSP00000023258, ENSMUST00000002274.9, OTTMUST00000049974
    Conserved Domains (2) summary
    pfam00026
    Location:72396
    Asp; Eukaryotic aspartyl protease
    cl11403
    Location:68394
    pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

    Range
    44572445..44586846
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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