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MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 [ Homo sapiens (human) ]

Gene ID: 9448, updated on 3-Jan-2021

Summary

Official Symbol
MAP4K4provided by HGNC
Official Full Name
mitogen-activated protein kinase kinase kinase kinase 4provided by HGNC
Primary source
HGNC:HGNC:6866
See related
Ensembl:ENSG00000071054 MIM:604666
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HGK; NIK; MEKKK4; FLH21957; HEL-S-31
Summary
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 42.7), fat (RPKM 25.1) and 23 other tissues See more
Orthologs
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Genomic context

See MAP4K4 in Genome Data Viewer
Location:
2q11.2
Exon count:
33
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (101697707..101894690)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (102314165..102511152)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373514 Neighboring gene PRCP pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 1127 Neighboring gene interleukin 1 receptor type 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10410, FLJ20373, FLJ90111, KIAA0687

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
creatine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
NOT microvillus assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell-matrix adhesion NAS
Non-traceable Author Statement
more info
PubMed 
neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of ARF protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of focal adhesion assembly ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of focal adhesion disassembly ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of keratinocyte migration ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
stress-activated protein kinase signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mitogen-activated protein kinase kinase kinase kinase 4
Names
HPK/GCK-like kinase HGK
MAPK/ERK kinase kinase kinase 4
MEK kinase kinase 4
Ste20 group protein kinase HGK
epididymis secretory protein Li 31
hepatocyte progenitor kinase-like/germinal center kinase-like kinase
nck-interacting kinase
NP_001229488.1
NP_001229489.1
NP_001371405.1
NP_001371406.1
NP_001371407.1
NP_001371410.1
NP_001371411.1
NP_001371412.1
NP_001371413.1
NP_001371414.1
NP_001371415.1
NP_001371416.1
NP_001371417.1
NP_001371419.1
NP_001371420.1
NP_001371421.1
NP_001371422.1
NP_001371423.1
NP_001371424.1
NP_001371425.1
NP_001371426.1
NP_001371435.1
NP_001371436.1
NP_001371437.1
NP_001371438.1
NP_001371449.1
NP_001371472.1
NP_001371477.1
NP_001371478.1
NP_001371479.1
NP_001371480.1
NP_001371481.1
NP_001371482.1
NP_001371483.1
NP_001371484.1
NP_001371485.1
NP_001371486.1
NP_001371487.1
NP_001371488.1
NP_001371489.1
NP_001371490.1
NP_001371491.1
NP_001371492.1
NP_001371493.1
NP_001371496.1
NP_001371501.1
NP_001371508.1
NP_004825.3
NP_663719.2
NP_663720.1
XP_005264105.1
XP_005264107.1
XP_005264109.1
XP_005264114.1
XP_005264116.1
XP_005264117.1
XP_005264119.1
XP_005264120.1
XP_005264122.1
XP_005264123.1
XP_005264125.1
XP_005264126.1
XP_005264128.1
XP_006712928.1
XP_016860840.1
XP_016860843.1
XP_016860845.1
XP_016860846.1
XP_016860847.1
XP_016860849.1
XP_016860852.1
XP_016860855.1
XP_016860857.1
XP_016860858.1
XP_016860860.1
XP_016860861.1
XP_016860862.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242559.2NP_001229488.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 4

    See identical proteins and their annotated locations for NP_001229488.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses two alternate in-frame splice sites and lacks an alternate in-frame exon in the central coding region, compared to variant 2. The encoded isoform (4) is shorter than isoform 2. The 5' UTR of this variant is incomplete due to a lack of 5'-complete transcripts representing this variant, and the presence of splicing ambiguity in the 5' UTR.
    Source sequence(s)
    AC005035, AC007005, AY212247, BU625485, DB086475
    Consensus CDS
    CCDS56130.1
    UniProtKB/Swiss-Prot
    O95819
    Related
    ENSP00000314363.6, ENST00000347699.8
    Conserved Domains (2) summary
    smart00036
    Location:9211219
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001242560.2NP_001229489.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two alternate in-frame exons but includes two different alternate in-frame exons in the central coding region, compared to variant 2. The encoded isoform (5) is shorter than isoform 2.
    Source sequence(s)
    AC005035, AC007005, AK296396, BU625485, DR002278
    UniProtKB/TrEMBL
    B7Z3V5
    Related
    ENSP00000313644.5, ENST00000324219.8
    Conserved Domains (3) summary
    smart00036
    Location:9171215
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  3. NM_001384476.1NP_001371405.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  4. NM_001384477.1NP_001371406.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  5. NM_001384478.1NP_001371407.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  6. NM_001384481.1NP_001371410.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:9861292
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  7. NM_001384482.1NP_001371411.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  8. NM_001384483.1NP_001371412.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  9. NM_001384484.1NP_001371413.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  10. NM_001384485.1NP_001371414.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  11. NM_001384486.1NP_001371415.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  12. NM_001384487.1NP_001371416.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  13. NM_001384488.1NP_001371417.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  14. NM_001384490.1NP_001371419.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Related
    ENSP00000303600.6, ENST00000302217.9
    Conserved Domains (2) summary
    smart00036
    Location:8711169
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06636
    Location:8289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
  15. NM_001384491.1NP_001371420.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  16. NM_001384492.1NP_001371421.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  17. NM_001384493.1NP_001371422.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  18. NM_001384494.1NP_001371423.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 22

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  19. NM_001384495.1NP_001371424.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:9041202
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06636
    Location:8289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
  20. NM_001384496.1NP_001371425.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 24

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:9321238
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  21. NM_001384497.1NP_001371426.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 25

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  22. NM_001384506.1NP_001371435.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Related
    ENSP00000486116.1, ENST00000625522.2
  23. NM_001384507.1NP_001371436.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 28

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  24. NM_001384508.1NP_001371437.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 29

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  25. NM_001384509.1NP_001371438.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 30

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  26. NM_001384520.1NP_001371449.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 31

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  27. NM_001384543.1NP_001371472.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 32

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  28. NM_001384548.1NP_001371477.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 35

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  29. NM_001384549.1NP_001371478.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 36

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  30. NM_001384550.1NP_001371479.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 37

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  31. NM_001384551.1NP_001371480.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 38

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  32. NM_001384552.1NP_001371481.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 39

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  33. NM_001384553.1NP_001371482.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 40

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  34. NM_001384554.1NP_001371483.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 41

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  35. NM_001384555.1NP_001371484.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 42

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  36. NM_001384556.1NP_001371485.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 43

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  37. NM_001384557.1NP_001371486.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 44

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Related
    ENSP00000409720.1, ENST00000417294.5
  38. NM_001384558.1NP_001371487.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 45

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  39. NM_001384559.1NP_001371488.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 46

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  40. NM_001384560.1NP_001371489.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 47

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  41. NM_001384561.1NP_001371490.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 48

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  42. NM_001384562.1NP_001371491.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 49

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  43. NM_001384563.1NP_001371492.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 50

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  44. NM_001384564.1NP_001371493.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 51

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  45. NM_001384567.1NP_001371496.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 52

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  46. NM_001384572.1NP_001371501.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 53

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  47. NM_001384579.1NP_001371508.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 54

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  48. NM_004834.5NP_004825.3  mitogen-activated protein kinase kinase kinase kinase 4 isoform 1

    See identical proteins and their annotated locations for NP_004825.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks two alternate in-frame exons but includes a different in-frame exon in the central coding region, and uses an alternate in-frame splice site in both the central and 3' coding regions, compared to variant 2. The encoded isoform (1) is shorter than isoform 2.
    Source sequence(s)
    AC005035, AC007005, AF096300, BU625485, DR002278
    Consensus CDS
    CCDS82487.1
    UniProtKB/Swiss-Prot
    O95819
    Related
    ENSP00000489579.1, ENST00000634702.1
    Conserved Domains (2) summary
    smart00036
    Location:8391145
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06636
    Location:8289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
  49. NM_145686.4NP_663719.2  mitogen-activated protein kinase kinase kinase kinase 4 isoform 2

    See identical proteins and their annotated locations for NP_663719.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).
    Source sequence(s)
    AC005035, AC007005, BC064691, BU625485, DR002278
    Consensus CDS
    CCDS74546.1
    UniProtKB/Swiss-Prot
    O95819
    Related
    ENSP00000343658.5, ENST00000350878.8
    Conserved Domains (2) summary
    smart00036
    Location:9551253
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  50. NM_145687.4NP_663720.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 3

    See identical proteins and their annotated locations for NP_663720.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon but includes a different in-frame exon in the central coding region, compared to variant 2. The encoded isoform (3) is shorter than isoform 2. The 5' UTR of this variant is incomplete due to a lack of 5'-complete transcripts representing this variant, and the presence of splicing ambiguity in the 5' UTR.
    Source sequence(s)
    AB014587, AC005035, AC007005, BU625485, DB086475
    UniProtKB/Swiss-Prot
    O95819
    UniProtKB/TrEMBL
    V9HWH3
    Conserved Domains (2) summary
    smart00036
    Location:8941192
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. NR_169279.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  2. NR_169280.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  3. NR_169281.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  4. NR_169282.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    101697707..101894690
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264048.2XP_005264105.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X1

    Conserved Domains (3) summary
    smart00036
    Location:10661364
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  2. XM_005264057.3XP_005264114.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X6

    Conserved Domains (2) summary
    smart00036
    Location:9891295
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  3. XM_017005351.1XP_016860840.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X8

  4. XM_005264050.3XP_005264107.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X3

    Conserved Domains (3) summary
    smart00036
    Location:10121318
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  5. XM_005264052.3XP_005264109.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X4

    Conserved Domains (3) summary
    smart00036
    Location:10111317
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  6. XM_017005360.1XP_016860849.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X20

  7. XM_005264062.3XP_005264119.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X23

    Conserved Domains (2) summary
    smart00036
    Location:9351241
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  8. XM_017005363.1XP_016860852.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X26

  9. XM_017005371.1XP_016860860.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X39

    Related
    ENSP00000487176.1, ENST00000627726.2
  10. XM_005264063.3XP_005264120.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X24

    Conserved Domains (2) summary
    smart00036
    Location:9341240
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  11. XM_017005369.1XP_016860858.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X36

  12. XM_005264071.2XP_005264128.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X40

    Related
    ENSP00000389752.1, ENST00000413150.6
    Conserved Domains (2) summary
    smart00036
    Location:8671165
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06636
    Location:8289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
  13. XM_005264059.3XP_005264116.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X14

    Conserved Domains (2) summary
    smart00036
    Location:9581264
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  14. XM_017005357.1XP_016860846.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X17

  15. XM_017005356.1XP_016860845.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X15

  16. XM_005264069.2XP_005264126.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X35

    Conserved Domains (2) summary
    smart00036
    Location:8911189
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  17. XM_017005358.1XP_016860847.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X18

  18. XM_017005368.1XP_016860857.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X34

  19. XM_005264060.3XP_005264117.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X16

    Conserved Domains (2) summary
    smart00036
    Location:9541260
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  20. XM_006712865.2XP_006712928.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X10

    Conserved Domains (3) summary
    smart00036
    Location:9811287
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  21. XM_017005354.1XP_016860843.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X12

  22. XM_017005366.1XP_016860855.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X29

  23. XM_005264065.3XP_005264122.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X31

    Conserved Domains (2) summary
    smart00036
    Location:9041210
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  24. XM_017005372.1XP_016860861.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X41

  25. XM_005264068.3XP_005264125.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X33

    Conserved Domains (3) summary
    smart00036
    Location:9011207
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  26. XM_017005373.1XP_016860862.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X42

  27. XM_005264066.3XP_005264123.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X32

    Conserved Domains (2) summary
    smart00036
    Location:9031209
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
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