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MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 [ Homo sapiens (human) ]

Gene ID: 9448, updated on 7-Oct-2018

Summary

Official Symbol
MAP4K4provided by HGNC
Official Full Name
mitogen-activated protein kinase kinase kinase kinase 4provided by HGNC
Primary source
HGNC:HGNC:6866
See related
Ensembl:ENSG00000071054 MIM:604666; Vega:OTTHUMG00000155394
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HGK; NIK; MEKKK4; FLH21957; HEL-S-31
Summary
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 42.7), fat (RPKM 25.1) and 23 other tissues See more
Orthologs

Genomic context

See MAP4K4 in Genome Data Viewer
Location:
2q11.2
Exon count:
33
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (101697703..101894690)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (102314165..102511152)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene prolylcarboxypeptidase (angiotensinase C) pseudogene Neighboring gene uncharacterized LOC105373514 Neighboring gene long intergenic non-protein coding RNA 1127 Neighboring gene interleukin 1 receptor type 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
NHGRI GWA Catalog

Pathways from BioSystems

  • Angiopoietin Like Protein 8 Regulatory Pathway, organism-specific biosystem (from WikiPathways)
    Angiopoietin Like Protein 8 Regulatory Pathway, organism-specific biosystemThe hepatic ANGPTL8 (Angiopoietin Like Protein 8) regulatory pathway represents an up-to-date curated interactive pathway for all of the interactions from the known regulators of ANGPTL8 and updated ...
  • Cellular Senescence, organism-specific biosystem (from REACTOME)
    Cellular Senescence, organism-specific biosystemCellular senescence involves irreversible growth arrest accompanied by phenotypic changes such as enlarged morphology, reorganization of chromatin through formation of senescence-associated heterochr...
  • Cellular responses to stress, organism-specific biosystem (from REACTOME)
    Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
  • Ceramide signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    Ceramide signaling pathway, organism-specific biosystem
    Ceramide signaling pathway
  • Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
    Direct p53 effectors, organism-specific biosystem
    Direct p53 effectors
  • EPHB forward signaling, organism-specific biosystem (from Pathway Interaction Database)
    EPHB forward signaling, organism-specific biosystem
    EPHB forward signaling
  • Insulin Signaling, organism-specific biosystem (from WikiPathways)
    Insulin Signaling, organism-specific biosystemInsulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose fro...
  • MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
    MAPK Signaling Pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • Oxidative Stress Induced Senescence, organism-specific biosystem (from REACTOME)
    Oxidative Stress Induced Senescence, organism-specific biosystemOxidative stress, caused by increased concentration of reactive oxygen species (ROS) in the cell, can happen as a consequence of mitochondrial dysfunction induced by the oncogenic RAS (Moiseeva et al...
  • TNF receptor signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    TNF receptor signaling pathway, organism-specific biosystem
    TNF receptor signaling pathway

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10410, FLJ20373, FLJ90111, KIAA0687

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
creatine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
NOT microvillus assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell-matrix adhesion NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of insulin secretion involved in cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron projection regeneration IEA
Inferred from Electronic Annotation
more info
 
neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of ARF protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of adherens junction organization ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of focal adhesion assembly ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of keratinocyte migration ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction by protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
stress-activated protein kinase signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mitogen-activated protein kinase kinase kinase kinase 4
Names
HPK/GCK-like kinase HGK
MAPK/ERK kinase kinase kinase 4
MEK kinase kinase 4
Ste20 group protein kinase HGK
epididymis secretory protein Li 31
hepatocyte progenitor kinase-like/germinal center kinase-like kinase
nck-interacting kinase
NP_001229488.1
NP_001229489.1
NP_004825.3
NP_663719.2
NP_663720.1
XP_005264105.1
XP_005264107.1
XP_005264109.1
XP_005264114.1
XP_005264115.1
XP_005264116.1
XP_005264117.1
XP_005264119.1
XP_005264120.1
XP_005264121.1
XP_005264122.1
XP_005264123.1
XP_005264125.1
XP_005264126.1
XP_005264128.1
XP_006712928.1
XP_006712931.1
XP_006712932.1
XP_016860838.1
XP_016860839.1
XP_016860840.1
XP_016860841.1
XP_016860842.1
XP_016860843.1
XP_016860844.1
XP_016860845.1
XP_016860846.1
XP_016860847.1
XP_016860848.1
XP_016860849.1
XP_016860850.1
XP_016860851.1
XP_016860852.1
XP_016860853.1
XP_016860854.1
XP_016860855.1
XP_016860856.1
XP_016860857.1
XP_016860858.1
XP_016860859.1
XP_016860860.1
XP_016860861.1
XP_016860862.1
XP_016860863.1
XP_016860864.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242559.1NP_001229488.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 4

    See identical proteins and their annotated locations for NP_001229488.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses two alternate in-frame splice sites and lacks an alternate in-frame exon in the central coding region, compared to variant 2. The encoded isoform (4) is shorter than isoform 2. The 5' UTR of this variant is incomplete due to a lack of 5'-complete transcripts representing this variant, and the presence of splicing ambiguity in the 5' UTR.
    Source sequence(s)
    AC005035, AY212247, BU625485, DB086475
    Consensus CDS
    CCDS56130.1
    UniProtKB/Swiss-Prot
    O95819
    Related
    ENSP00000314363.6, OTTHUMP00000207903, ENST00000347699.8, OTTHUMT00000339839
    Conserved Domains (2) summary
    smart00036
    Location:9211219
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001242560.1NP_001229489.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two alternate in-frame exons but includes two different alternate in-frame exons in the central coding region, compared to variant 2. The encoded isoform (5) is shorter than isoform 2.
    Source sequence(s)
    AC005035, AC007005, AK296396, BU625485, DR002278
    UniProtKB/TrEMBL
    B7Z3V5
    Related
    ENSP00000313644.5, ENST00000324219.8
    Conserved Domains (3) summary
    smart00036
    Location:9171215
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  3. NM_004834.4NP_004825.3  mitogen-activated protein kinase kinase kinase kinase 4 isoform 1

    See identical proteins and their annotated locations for NP_004825.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks two alternate in-frame exons but includes a different in-frame exon in the central coding region, and uses an alternate in-frame splice site in both the central and 3' coding regions, compared to variant 2. The encoded isoform (1) is shorter than isoform 2.
    Source sequence(s)
    AC005035, AC007005, AF096300, BU625485, DR002278
    Consensus CDS
    CCDS82487.1
    UniProtKB/Swiss-Prot
    O95819
    Related
    ENSP00000489579.1, OTTHUMP00000281202, ENST00000634702.1, OTTHUMT00000488049
    Conserved Domains (2) summary
    smart00036
    Location:8391145
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06636
    Location:8289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
  4. NM_145686.3NP_663719.2  mitogen-activated protein kinase kinase kinase kinase 4 isoform 2

    See identical proteins and their annotated locations for NP_663719.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).
    Source sequence(s)
    AC005035, AC007005, BC064691, BU625485, DR002278
    Consensus CDS
    CCDS74546.1
    UniProtKB/Swiss-Prot
    O95819
    Related
    ENSP00000343658.5, ENST00000350878.8
    Conserved Domains (2) summary
    smart00036
    Location:9551253
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  5. NM_145687.3NP_663720.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 3

    See identical proteins and their annotated locations for NP_663720.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon but includes a different in-frame exon in the central coding region, compared to variant 2. The encoded isoform (3) is shorter than isoform 2. The 5' UTR of this variant is incomplete due to a lack of 5'-complete transcripts representing this variant, and the presence of splicing ambiguity in the 5' UTR.
    Source sequence(s)
    AB014587, AC005035, BU625485, DB086475
    UniProtKB/Swiss-Prot
    O95819
    UniProtKB/TrEMBL
    V9HWH3
    Conserved Domains (3) summary
    smart00036
    Location:8941192
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    101697703..101894690
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264048.2XP_005264105.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X1

    Conserved Domains (3) summary
    smart00036
    Location:10661364
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  2. XM_005264057.3XP_005264114.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X6

    Conserved Domains (3) summary
    smart00036
    Location:9891295
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  3. XM_017005352.1XP_016860841.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X9

  4. XM_017005365.1XP_016860854.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X28

  5. XM_005264058.3XP_005264115.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X7

    Conserved Domains (3) summary
    smart00036
    Location:9861292
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  6. XM_017005353.1XP_016860842.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X11

  7. XM_017005351.1XP_016860840.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X8

  8. XM_005264050.3XP_005264107.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X3

    Conserved Domains (3) summary
    smart00036
    Location:10121318
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  9. XM_017005350.1XP_016860839.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X5

  10. XM_017005359.1XP_016860848.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X19

  11. XM_017005361.1XP_016860850.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X21

    Related
    ENSP00000486116.1, ENST00000625522.2
  12. XM_005264052.3XP_005264109.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X4

    Conserved Domains (3) summary
    smart00036
    Location:10111317
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  13. XM_017005360.1XP_016860849.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X20

  14. XM_017005362.1XP_016860851.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X22

  15. XM_005264062.3XP_005264119.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X23

    Conserved Domains (3) summary
    smart00036
    Location:9351241
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  16. XM_017005363.1XP_016860852.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X26

  17. XM_006712869.2XP_006712932.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X37

    Related
    ENSP00000303600.6, ENST00000302217.9
    Conserved Domains (3) summary
    smart00036
    Location:8711169
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06636
    Location:8289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
  18. XM_005264064.3XP_005264121.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X25

    Conserved Domains (3) summary
    smart00036
    Location:9321238
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  19. XM_017005371.1XP_016860860.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X39

    Related
    ENSP00000487176.1, ENST00000627726.2
  20. XM_005264063.3XP_005264120.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X24

    Conserved Domains (3) summary
    smart00036
    Location:9341240
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  21. XM_017005369.1XP_016860858.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X36

  22. XM_017005370.1XP_016860859.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X38

  23. XM_017005364.1XP_016860853.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X27

  24. XM_005264071.2XP_005264128.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X40

    Related
    ENSP00000387370.1, OTTHUMP00000207973, ENST00000456652.5, OTTHUMT00000339994
    Conserved Domains (3) summary
    smart00036
    Location:8671165
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06636
    Location:8289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
  25. XM_017005349.1XP_016860838.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X2

  26. XM_005264059.3XP_005264116.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X14

    Conserved Domains (3) summary
    smart00036
    Location:9581264
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  27. XM_017005357.1XP_016860846.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X17

  28. XM_017005356.1XP_016860845.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X15

  29. XM_005264069.2XP_005264126.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X35

    Related
    ENSP00000409720.1, OTTHUMP00000207972, ENST00000417294.5, OTTHUMT00000339993
    Conserved Domains (3) summary
    smart00036
    Location:8911189
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  30. XM_017005358.1XP_016860847.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X18

  31. XM_017005368.1XP_016860857.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X34

  32. XM_005264060.3XP_005264117.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X16

    Conserved Domains (3) summary
    smart00036
    Location:9541260
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  33. XM_006712865.2XP_006712928.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X10

    Conserved Domains (3) summary
    smart00036
    Location:9811287
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  34. XM_017005354.1XP_016860843.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X12

  35. XM_017005366.1XP_016860855.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X29

  36. XM_017005355.1XP_016860844.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X13

  37. XM_017005367.1XP_016860856.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X30

  38. XM_005264065.3XP_005264122.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X31

    Conserved Domains (3) summary
    smart00036
    Location:9041210
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  39. XM_006712868.2XP_006712931.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X45

    Conserved Domains (3) summary
    smart00036
    Location:9041202
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06636
    Location:8289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
  40. XM_017005372.1XP_016860861.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X41

  41. XM_017005374.1XP_016860863.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X43

  42. XM_005264068.3XP_005264125.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X33

    Conserved Domains (3) summary
    smart00036
    Location:9011207
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  43. XM_017005373.1XP_016860862.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X42

  44. XM_017005375.1XP_016860864.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X44

    Related
    ENSP00000389752.1, OTTHUMP00000207971, ENST00000413150.6, OTTHUMT00000339992
  45. XM_005264066.3XP_005264123.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X32

    Conserved Domains (3) summary
    smart00036
    Location:9031209
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
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