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MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 [ Homo sapiens (human) ]

Gene ID: 9448, updated on 6-Nov-2022

Summary

Official Symbol
MAP4K4provided by HGNC
Official Full Name
mitogen-activated protein kinase kinase kinase kinase 4provided by HGNC
Primary source
HGNC:HGNC:6866
See related
Ensembl:ENSG00000071054 MIM:604666; AllianceGenome:HGNC:6866
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HGK; NIK; MEKKK4; FLH21957; HEL-S-31
Summary
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 42.7), fat (RPKM 25.1) and 23 other tissues See more
Orthologs
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Genomic context

See MAP4K4 in Genome Data Viewer
Location:
2q11.2
Exon count:
33
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (101697707..101894690)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (102156317..102352940)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (102314169..102511152)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373514 Neighboring gene PRCP pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 8953 Neighboring gene Sharpr-MPRA regulatory region 3767 Neighboring gene long intergenic non-protein coding RNA 1127 Neighboring gene interleukin 1 receptor type 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10410, FLJ20373, FLJ90111, KIAA0687

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables creatine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
NOT involved_in microvillus assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell-matrix adhesion NAS
Non-traceable Author Statement
more info
PubMed 
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of ARF protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of focal adhesion assembly ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of focal adhesion disassembly ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of keratinocyte migration ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mitogen-activated protein kinase kinase kinase kinase 4
Names
HPK/GCK-like kinase HGK
MAPK/ERK kinase kinase kinase 4
MEK kinase kinase 4
Ste20 group protein kinase HGK
epididymis secretory protein Li 31
hepatocyte progenitor kinase-like/germinal center kinase-like kinase
nck-interacting kinase
NP_001229488.1
NP_001229489.1
NP_001371405.1
NP_001371406.1
NP_001371407.1
NP_001371410.1
NP_001371411.1
NP_001371412.1
NP_001371413.1
NP_001371414.1
NP_001371415.1
NP_001371416.1
NP_001371417.1
NP_001371419.1
NP_001371420.1
NP_001371421.1
NP_001371422.1
NP_001371423.1
NP_001371424.1
NP_001371425.1
NP_001371426.1
NP_001371435.1
NP_001371436.1
NP_001371437.1
NP_001371438.1
NP_001371449.1
NP_001371472.1
NP_001371477.1
NP_001371478.1
NP_001371479.1
NP_001371480.1
NP_001371481.1
NP_001371482.1
NP_001371483.1
NP_001371484.1
NP_001371485.1
NP_001371486.1
NP_001371487.1
NP_001371488.1
NP_001371489.1
NP_001371490.1
NP_001371491.1
NP_001371492.1
NP_001371493.1
NP_001371496.1
NP_001371501.1
NP_001371508.1
NP_001381931.1
NP_004825.3
NP_663719.2
NP_663720.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242559.2NP_001229488.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 4

    See identical proteins and their annotated locations for NP_001229488.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses two alternate in-frame splice sites and lacks an alternate in-frame exon in the central coding region, compared to variant 2. The encoded isoform (4) is shorter than isoform 2. The 5' UTR of this variant is incomplete due to a lack of 5'-complete transcripts representing this variant, and the presence of splicing ambiguity in the 5' UTR.
    Source sequence(s)
    AC005035, AC007005, AY212247, BU625485, DB086475
    Consensus CDS
    CCDS56130.1
    UniProtKB/Swiss-Prot
    O95819, Q9NST7
    Related
    ENSP00000314363.6, ENST00000347699.8
    Conserved Domains (2) summary
    smart00036
    Location:9211219
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001242560.2NP_001229489.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two alternate in-frame exons but includes two different alternate in-frame exons in the central coding region, compared to variant 2. The encoded isoform (5) is shorter than isoform 2.
    Source sequence(s)
    AC005035, AC007005, AK296396, BU625485, DR002278
    Consensus CDS
    CCDS92823.1
    UniProtKB/TrEMBL
    B7Z3V5, E7EN19
    Related
    ENSP00000392830.2, ENST00000425019.6
    Conserved Domains (3) summary
    smart00036
    Location:9171215
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  3. NM_001384476.1NP_001371405.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:9471245
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  4. NM_001384477.1NP_001371406.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:10101308
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  5. NM_001384478.1NP_001371407.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:8401138
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06636
    Location:8289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
  6. NM_001384481.1NP_001371410.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:9861292
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  7. NM_001384482.1NP_001371411.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Related
    ENSP00000389752.1, ENST00000413150.6
    Conserved Domains (2) summary
    smart00036
    Location:8371135
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06636
    Location:8289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
  8. NM_001384483.1NP_001371412.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:9311229
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06636
    Location:8289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
  9. NM_001384484.1NP_001371413.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:9481246
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  10. NM_001384485.1NP_001371414.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:9481254
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  11. NM_001384486.1NP_001371415.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:9891287
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  12. NM_001384487.1NP_001371416.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:9781276
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  13. NM_001384488.1NP_001371417.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:9881286
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  14. NM_001384490.1NP_001371419.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:8711169
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06636
    Location:8289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
  15. NM_001384491.1NP_001371420.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:9161214
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  16. NM_001384492.1NP_001371421.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:10341332
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  17. NM_001384493.1NP_001371422.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:10121310
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  18. NM_001384494.1NP_001371423.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 22

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Related
    ENSP00000387370.1, ENST00000456652.5
    Conserved Domains (2) summary
    smart00036
    Location:8701168
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06636
    Location:8289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
  19. NM_001384495.1NP_001371424.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:9041202
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06636
    Location:8289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
  20. NM_001384496.1NP_001371425.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 24

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:9321238
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  21. NM_001384497.1NP_001371426.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 25

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:10631361
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  22. NM_001384506.1NP_001371435.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:10021300
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  23. NM_001384507.1NP_001371436.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 28

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:9251223
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  24. NM_001384508.1NP_001371437.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 29

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:9461244
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  25. NM_001384509.1NP_001371438.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 30

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:9771275
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  26. NM_001384520.1NP_001371449.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 31

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:9681266
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  27. NM_001384543.1NP_001371472.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 32

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:9711269
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  28. NM_001384548.1NP_001371477.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 35

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:9831281
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  29. NM_001384549.1NP_001371478.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 36

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:8951193
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:6280
    PKc_like; Protein Kinases, catalytic domain
  30. NM_001384550.1NP_001371479.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 37

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:9101208
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:6280
    PKc_like; Protein Kinases, catalytic domain
  31. NM_001384551.1NP_001371480.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 38

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:8851183
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:6280
    PKc_like; Protein Kinases, catalytic domain
  32. NM_001384552.1NP_001371481.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 39

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:9381236
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:6280
    PKc_like; Protein Kinases, catalytic domain
  33. NM_001384553.1NP_001371482.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 40

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:10011299
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:6280
    PKc_like; Protein Kinases, catalytic domain
  34. NM_001384554.1NP_001371483.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 41

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:9051211
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:6280
    PKc_like; Protein Kinases, catalytic domain
  35. NM_001384555.1NP_001371484.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 42

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:10031301
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:6280
    PKc_like; Protein Kinases, catalytic domain
  36. NM_001384556.1NP_001371485.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 43

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:9361234
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:6280
    PKc_like; Protein Kinases, catalytic domain
  37. NM_001384557.1NP_001371486.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 44

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Related
    ENSP00000409720.1, ENST00000417294.5
    Conserved Domains (2) summary
    smart00036
    Location:8821180
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:6280
    PKc_like; Protein Kinases, catalytic domain
  38. NM_001384558.1NP_001371487.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 45

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:9081206
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:6280
    PKc_like; Protein Kinases, catalytic domain
  39. NM_001384559.1NP_001371488.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 46

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:8941192
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:6280
    PKc_like; Protein Kinases, catalytic domain
  40. NM_001384560.1NP_001371489.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 47

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:8591157
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:6280
    PKc_like; Protein Kinases, catalytic domain
  41. NM_001384561.1NP_001371490.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 48

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:8311129
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:6280
    PKc_like; Protein Kinases, catalytic domain
  42. NM_001384562.1NP_001371491.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 49

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:9371235
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:6280
    PKc_like; Protein Kinases, catalytic domain
  43. NM_001384563.1NP_001371492.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 50

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:10001298
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:6280
    PKc_like; Protein Kinases, catalytic domain
  44. NM_001384564.1NP_001371493.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 51

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:10231321
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:6280
    PKc_like; Protein Kinases, catalytic domain
  45. NM_001384567.1NP_001371496.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 52

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:9721270
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:6280
    PKc_like; Protein Kinases, catalytic domain
  46. NM_001384572.1NP_001371501.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 53

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:9391237
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:6280
    PKc_like; Protein Kinases, catalytic domain
  47. NM_001384579.1NP_001371508.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 54

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Conserved Domains (2) summary
    smart00036
    Location:9161214
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:6280
    PKc_like; Protein Kinases, catalytic domain
  48. NM_001395002.1NP_001381931.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 55

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Consensus CDS
    CCDS92821.1
    UniProtKB/TrEMBL
    G5E948
    Related
    ENSP00000313644.6, ENST00000324219.9
    Conserved Domains (2) summary
    smart00036
    Location:10661364
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  49. NM_004834.5NP_004825.3  mitogen-activated protein kinase kinase kinase kinase 4 isoform 1

    See identical proteins and their annotated locations for NP_004825.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks two alternate in-frame exons but includes a different in-frame exon in the central coding region, and uses an alternate in-frame splice site in both the central and 3' coding regions, compared to variant 2. The encoded isoform (1) is shorter than isoform 2.
    Source sequence(s)
    AC005035, AC007005, AF096300, BU625485, DR002278
    Consensus CDS
    CCDS82487.1
    UniProtKB/Swiss-Prot
    O95819
    Related
    ENSP00000489579.1, ENST00000634702.1
    Conserved Domains (2) summary
    smart00036
    Location:8391145
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06636
    Location:8289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
  50. NM_145686.4NP_663719.2  mitogen-activated protein kinase kinase kinase kinase 4 isoform 2

    See identical proteins and their annotated locations for NP_663719.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).
    Source sequence(s)
    AC005035, AC007005, BC064691, BU625485, DR002278
    Consensus CDS
    CCDS74546.1
    UniProtKB/Swiss-Prot
    O95819
    Related
    ENSP00000343658.5, ENST00000350878.9
    Conserved Domains (2) summary
    smart00036
    Location:9551253
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  51. NM_145687.4NP_663720.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 3

    See identical proteins and their annotated locations for NP_663720.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon but includes a different in-frame exon in the central coding region, compared to variant 2. The encoded isoform (3) is shorter than isoform 2. The 5' UTR of this variant is incomplete due to a lack of 5'-complete transcripts representing this variant, and the presence of splicing ambiguity in the 5' UTR.
    Source sequence(s)
    AB014587, AC005035, AC007005, BU625485, DB086475
    Consensus CDS
    CCDS92822.1
    UniProtKB/Swiss-Prot
    O95819
    UniProtKB/TrEMBL
    V9HWH3
    Related
    ENSP00000486116.2, ENST00000625522.3
    Conserved Domains (2) summary
    smart00036
    Location:8941192
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. NR_169279.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  2. NR_169280.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  3. NR_169281.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
  4. NR_169282.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    101697707..101894690
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    102156317..102352940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)