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Sfxn5 sideroflexin 5 [ Mus musculus (house mouse) ]

Gene ID: 94282, updated on 3-Nov-2024

Summary

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Official Symbol
Sfxn5provided by MGI
Official Full Name
sideroflexin 5provided by MGI
Primary source
MGI:MGI:2137681
See related
Ensembl:ENSMUSG00000033720 AllianceGenome:MGI:2137681
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C230001H08Rik
Summary
Predicted to enable citrate transmembrane transporter activity. Involved in positive regulation of cold-induced thermogenesis. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; brain; connective tissue; genitourinary system; and spinal cord. Orthologous to human SFXN5 (sideroflexin 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in cerebellum adult (RPKM 29.0), frontal lobe adult (RPKM 25.7) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See Sfxn5 in Genome Data Viewer
Location:
6 C3; 6 37.23 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (85190031..85310488, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (85213049..85333482, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53291 Neighboring gene empty spiracles homeobox 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:85187210-85187411 Neighboring gene STARR-seq mESC enhancer starr_16498 Neighboring gene STARR-positive B cell enhancer ABC_E4838 Neighboring gene STARR-positive B cell enhancer ABC_E10387 Neighboring gene RAB11 family interacting protein 5 (class I) Neighboring gene microRNA 705 Neighboring gene RIKEN cDNA 4933423K11 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Architecture of the outbred brown fat proteome defines regulators of metabolic physiology. Xiao H, et al. Cell, 2022 Nov 23. PMID 36334589, Free PMC Article
  2. The human sideroflexin 5 (SFXN5) gene: sequence, expression analysis and exclusion as a candidate for PARK3. Lockhart PJ, et al. Gene, 2002 Feb 20. PMID 12039050
  3. Autocrine IL-10 impairs dendritic cell (DC)-derived immune responses to mycobacterial infection by suppressing DC trafficking to draining lymph nodes and local IL-12 production. Demangel C, et al. Eur J Immunol, 2002 Apr. PMID 11920565
  4. Identification of the mammalian Not gene via a phylogenomic approach. Plouhinec JL, et al. Gene Expr Patterns, 2004 Nov. PMID 15533813
  5. A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice. Fleming MD, et al. Genes Dev, 2001 Mar 15. PMID 11274051, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables citrate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables citrate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables monoatomic ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in citrate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in citrate transport ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cold-induced thermogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane HDA PubMed 
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISA
Inferred from Sequence Alignment
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sideroflexin-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178639.4 → NP_848754.1  sideroflexin-5

    See identical proteins and their annotated locations for NP_848754.1

    Status: VALIDATED

    Source sequence(s)
    AK036285, AK082073, BB628882, BC099507
    Consensus CDS
    CCDS20291.1
    UniProtKB/Swiss-Prot
    Q8BGG3, Q925N0
    UniProtKB/TrEMBL
    Q8BRQ9
    Related
    ENSMUSP00000041872.6, ENSMUST00000045846.12
    Conserved Domains (1) summary
    pfam03820
    Location:34 → 342
    Mtc; Tricarboxylate carrier

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    85190031..85310488 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152414.1 → XP_036008307.1  sideroflexin-5 isoform X3

    Conserved Domains (1) summary
    pfam03820
    Location:29 → 214
    Mtc; Tricarboxylate carrier

  2. XM_006506816.5 → XP_006506879.1  sideroflexin-5 isoform X1

    Conserved Domains (1) summary
    pfam03820
    Location:34 → 362
    Mtc; Tricarboxylate carrier

  3. XM_030255684.1 → XP_030111544.1  sideroflexin-5 isoform X2

    Conserved Domains (1) summary
    pfam03820
    Location:1 → 256
    Mtc; Tricarboxylate carrier
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q925N0.2 GenPept UniProtKB/Swiss-Prot:Q925N0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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