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TP53INP1 tumor protein p53 inducible nuclear protein 1 [ Homo sapiens (human) ]

Gene ID: 94241, updated on 24-Nov-2020

Summary

Official Symbol
TP53INP1provided by HGNC
Official Full Name
tumor protein p53 inducible nuclear protein 1provided by HGNC
Primary source
HGNC:HGNC:18022
See related
Ensembl:ENSG00000164938 MIM:606185
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIP; Teap; p53DINP1; TP53DINP1; TP53INP1A; TP53INP1B
Expression
Ubiquitous expression in liver (RPKM 25.0), testis (RPKM 21.8) and 25 other tissues See more
Orthologs

Genomic context

See TP53INP1 in Genome Data Viewer
Location:
8q22.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (94925972..94949378, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (95938200..95961615, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene dpy-19 like 4 Neighboring gene integrator complex subunit 8 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene cyclin E2 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 6 Neighboring gene Sharpr-MPRA regulatory region 2014 Neighboring gene RNA, U6 small nuclear 1209, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
GeneReviews: Not available
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22139, DKFZp434M1317

Gene Ontology Provided by GOA

Function Evidence Code Pubs
antioxidant activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
autophagic cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell cycle arrest TAS
Traceable Author Statement
more info
PubMed 
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
cellular response to UV IEA
Inferred from Electronic Annotation
more info
 
cellular response to ethanol IEA
Inferred from Electronic Annotation
more info
 
cellular response to hydroperoxide IEA
Inferred from Electronic Annotation
more info
 
cellular response to methyl methanesulfonate IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
negative regulation of myofibroblast differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of apoptotic process TAS
Traceable Author Statement
more info
 
regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
response to heat IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
PML body IEA
Inferred from Electronic Annotation
more info
 
autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autophagosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tumor protein p53-inducible nuclear protein 1
Names
p53-dependent damage-inducible nuclear protein 1
p53-inducible p53DINP1
stress-induced protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135733.2NP_001129205.1  tumor protein p53-inducible nuclear protein 1 isoform b

    See identical proteins and their annotated locations for NP_001129205.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon compared to variant 1 that has an in-frame stop codon in it. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AB017926, AF409114, DB086880
    Consensus CDS
    CCDS47899.1
    UniProtKB/Swiss-Prot
    Q96A56
    Related
    ENSP00000390063.2, ENST00000448464.6
    Conserved Domains (1) summary
    pfam14839
    Location:25159
    DOR; DOR family
  2. NM_033285.4NP_150601.1  tumor protein p53-inducible nuclear protein 1 isoform a

    See identical proteins and their annotated locations for NP_150601.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AB017926, AF409115, DB086880
    Consensus CDS
    CCDS6265.1
    UniProtKB/Swiss-Prot
    Q96A56
    UniProtKB/TrEMBL
    A0A024R9C8
    Related
    ENSP00000344215.4, ENST00000342697.5
    Conserved Domains (1) summary
    pfam14839
    Location:25231
    DOR; DOR family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    94925972..94949378 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517386.2XP_011515688.1  tumor protein p53-inducible nuclear protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011515688.1

    UniProtKB/Swiss-Prot
    Q96A56
    UniProtKB/TrEMBL
    A0A024R9C8
    Conserved Domains (1) summary
    pfam14839
    Location:25231
    DOR; DOR family
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