U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Trp53inp1 transformation related protein 53 inducible nuclear protein 1 [ Mus musculus (house mouse) ]

Gene ID: 60599, updated on 26-Sep-2022

Summary

Official Symbol
Trp53inp1provided by MGI
Official Full Name
transformation related protein 53 inducible nuclear protein 1provided by MGI
Primary source
MGI:MGI:1926609
See related
Ensembl:ENSMUSG00000028211 AllianceGenome:MGI:1926609
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SIP; Teap; SIP18; SIP27; Stinp; Tp53inp1; p53DINP1; 2700057G22Rik
Summary
Enables antioxidant activity. Involved in several processes, including negative regulation of fibroblast proliferation; negative regulation of myofibroblast differentiation; and regulation of gene expression. Acts upstream of or within several processes, including cellular response to ethanol; cellular response to hydroperoxide; and cellular response to methyl methanesulfonate. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study abdominal obesity-metabolic syndrome 1. Orthologous to human TP53INP1 (tumor protein p53 inducible nuclear protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 22.3), placenta adult (RPKM 6.2) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Trp53inp1 in Genome Data Viewer
Location:
4; 4 A1
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (11156441..11174379)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (11156441..11174379)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene microRNA 684-2 Neighboring gene SMT3 suppressor of mif two 3 homolog 2 pseudogene Neighboring gene RIKEN cDNA A630034I12 gene Neighboring gene cyclin E2 Neighboring gene integrator complex subunit 8

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables antioxidant activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in autophagic cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to UV IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to ethanol IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to hydroperoxide IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to methyl methanesulfonate IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of myofibroblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of autophagy IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to heat IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in autophagosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
NOT located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tumor protein p53-inducible nuclear protein 1
Names
p53-dependent damage-inducible nuclear protein 1
stress induced protein
thymus-expressed acidic protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199105.2NP_001186034.1  tumor protein p53-inducible nuclear protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001186034.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an additional exon in the coding region which results in a frameshift and early stop codon, compared to variant 1. It encodes a shorter isoform (2; also known as SIP18) with a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL840625
    UniProtKB/Swiss-Prot
    Q9QXE4
    Related
    ENSMUST00000132010.8
    Conserved Domains (1) summary
    pfam14839
    Location:24158
    DOR; DOR family
  2. NM_021897.4NP_068697.1  tumor protein p53-inducible nuclear protein 1 isoform 1

    See identical proteins and their annotated locations for NP_068697.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1; also known as SIP27).
    Source sequence(s)
    AL840625
    Consensus CDS
    CCDS17964.1
    UniProtKB/Swiss-Prot
    Q923I6, Q9QXE4
    UniProtKB/TrEMBL
    Q3UQK9
    Related
    ENSMUSP00000029865.4, ENSMUST00000029865.4
    Conserved Domains (1) summary
    pfam14839
    Location:24230
    DOR; DOR family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    11156441..11174379
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)