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GNG8 G protein subunit gamma 8 [ Homo sapiens (human) ]

Gene ID: 94235, updated on 25-Nov-2021

Summary

Official Symbol
GNG8provided by HGNC
Official Full Name
G protein subunit gamma 8provided by HGNC
Primary source
HGNC:HGNC:19664
See related
Ensembl:ENSG00000167414
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HG3E
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See GNG8 in Genome Data Viewer
Location:
19q13.32
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (46633953..46639326, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (47137333..47137939, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene PPP5 tetratricopeptide repeat domain containing 1, pseudogene Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 38 Neighboring gene calmodulin 3 Neighboring gene prostaglandin I2 receptor Neighboring gene dishevelled binding antagonist of beta catenin 3 Neighboring gene DACT3 antisense RNA 1 Neighboring gene protein kinase D2 Neighboring gene RNA, 7SL, cytoplasmic 364, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G-protein beta-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
Names
gamma-9
guanine nucleotide binding protein (G protein), gamma 8
heterotrimeric guanine nucleotide-binding protein 3E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033258.2NP_150283.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

    See identical proteins and their annotated locations for NP_150283.1

    Status: VALIDATED

    Source sequence(s)
    AC093503
    Consensus CDS
    CCDS12687.1
    UniProtKB/Swiss-Prot
    Q9UK08
    Conserved Domains (1) summary
    smart00224
    Location:870
    GGL; G protein gamma subunit-like motifs

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    46633953..46639326 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027505.1XP_016882994.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X2

    UniProtKB/Swiss-Prot
    Q9UK08
    Related
    ENSP00000300873.3, ENST00000300873.4
    Conserved Domains (1) summary
    smart00224
    Location:870
    GGL; G protein gamma subunit-like motifs
  2. XM_017027504.2XP_016882993.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X2

    UniProtKB/Swiss-Prot
    Q9UK08
    Conserved Domains (1) summary
    smart00224
    Location:870
    GGL; G protein gamma subunit-like motifs
  3. XM_011527524.2XP_011525826.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1

    See identical proteins and their annotated locations for XP_011525826.1

    Conserved Domains (1) summary
    smart00224
    Location:61123
    GGL; G protein gamma subunit-like motifs
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