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Gng8 guanine nucleotide binding protein (G protein), gamma 8 [ Mus musculus (house mouse) ]

Gene ID: 14709, updated on 18-Sep-2024

Summary

Official Symbol
Gng8provided by MGI
Official Full Name
guanine nucleotide binding protein (G protein), gamma 8provided by MGI
Primary source
MGI:MGI:109163
See related
Ensembl:ENSMUSG00000063594 AllianceGenome:MGI:109163
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hg3e; G(y)8
Summary
Predicted to enable G-protein beta-subunit binding activity. Acts upstream of or within cellular response to pheromone; nose development; and social behavior. Predicted to be located in plasma membrane. Predicted to be part of heterotrimeric G-protein complex. Is expressed in cochlear duct epithelium; retina; and spleen. Orthologous to human GNG8 (G protein subunit gamma 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 8.7), CNS E11.5 (RPKM 5.5) and 19 other tissues See more
Orthologs
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Genomic context

See Gng8 in Genome Data Viewer
Location:
7 A2; 7 9.15 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (16625687..16629361)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (16891737..16895451)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9330104G04 gene Neighboring gene STARR-positive B cell enhancer ABC_E3701 Neighboring gene STARR-positive B cell enhancer ABC_E443 Neighboring gene dishevelled-binding antagonist of beta-catenin 3 Neighboring gene prostaglandin I receptor (IP) Neighboring gene calmodulin 3 Neighboring gene predicted gene, 45972

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G-protein beta-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G-protein beta-subunit binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of heterotrimeric G-protein complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
Names
gamma-9
guanine nucleotide binding protein (G protein), gamma 8 subunit
heterotrimeric guanine nucleotide-binding protein 3e

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001412471.1NP_001399400.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

    Status: VALIDATED

    Source sequence(s)
    AC148981
    UniProtKB/Swiss-Prot
    P43426, P63078
    UniProtKB/TrEMBL
    Q3UMY0
    Related
    ENSMUSP00000145533.2, ENSMUST00000205459.2
  2. NM_001412472.1NP_001399401.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

    Status: VALIDATED

    Source sequence(s)
    AC148981
    UniProtKB/Swiss-Prot
    P43426, P63078
    UniProtKB/TrEMBL
    Q3UMY0
    Related
    ENSMUSP00000145567.2, ENSMUST00000205716.2
  3. NM_001412473.1NP_001399402.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

    Status: VALIDATED

    Source sequence(s)
    AC148981
    UniProtKB/Swiss-Prot
    P43426, P63078
    UniProtKB/TrEMBL
    Q3UMY0
  4. NM_001412474.1NP_001399403.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

    Status: VALIDATED

    Source sequence(s)
    AC148981
    UniProtKB/Swiss-Prot
    P43426, P63078
    UniProtKB/TrEMBL
    Q3UMY0
  5. NM_001412475.1NP_001399404.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

    Status: VALIDATED

    Source sequence(s)
    AC148981
    UniProtKB/Swiss-Prot
    P43426, P63078
    UniProtKB/TrEMBL
    Q3UMY0
  6. NM_001412476.1NP_001399405.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

    Status: VALIDATED

    Source sequence(s)
    AC148981
    UniProtKB/Swiss-Prot
    P43426, P63078
    UniProtKB/TrEMBL
    Q3UMY0
  7. NM_001412477.1NP_001399406.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

    Status: VALIDATED

    Source sequence(s)
    AC148981
    UniProtKB/Swiss-Prot
    P43426, P63078
    UniProtKB/TrEMBL
    Q3UMY0
  8. NM_010320.4NP_034450.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

    See identical proteins and their annotated locations for NP_034450.1

    Status: VALIDATED

    Source sequence(s)
    AC148981
    Consensus CDS
    CCDS20856.1
    UniProtKB/Swiss-Prot
    P43426, P63078
    UniProtKB/TrEMBL
    Q3UMY0
    Related
    ENSMUSP00000077314.5, ENSMUST00000078182.6
    Conserved Domains (1) summary
    smart00224
    Location:870
    GGL; G protein gamma subunit-like motifs

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    16625687..16629361
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)