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Spock2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2 [ Mus musculus (house mouse) ]

Gene ID: 94214, updated on 1-Oct-2021

Summary

Official Symbol
Spock2provided by MGI
Official Full Name
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2provided by MGI
Primary source
MGI:MGI:1891351
See related
Ensembl:ENSMUSG00000058297
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gcap; Gcap26; testic; AA407235; mKIAA0275
Expression
Biased expression in cerebellum adult (RPKM 116.0), cortex adult (RPKM 84.9) and 12 other tissues See more
Orthologs
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Genomic context

See Spock2 in Genome Data Viewer
Location:
10; 10 B4
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (59942079..59971020)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (60106257..60135198)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (59569005..59596662)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene DNA-damage-inducible transcript 4 Neighboring gene anaphase promoting complex subunit 16 Neighboring gene activating signal cointegrator 1 complex subunit 1 Neighboring gene predicted gene, 51801 Neighboring gene microRNA 6906 Neighboring gene predicted gene, 51802 Neighboring gene carbohydrate sulfotransferase 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

Markers

Homology

General protein information

Preferred Names
testican-2
Names
granule cell antiserum positive 26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052994.2NP_443720.1  testican-2 precursor

    See identical proteins and their annotated locations for NP_443720.1

    Status: PROVISIONAL

    Source sequence(s)
    BC057324
    Consensus CDS
    CCDS35910.1
    UniProtKB/Swiss-Prot
    Q9ER58
    Related
    ENSMUSP00000113115.3, ENSMUST00000121820.9
    Conserved Domains (4) summary
    smart00280
    Location:147180
    KAZAL; Kazal type serine protease inhibitors
    cd00191
    Location:311375
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd00252
    Location:198315
    SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
    pfam10591
    Location:197302
    SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    59942079..59971020
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514347.5XP_006514410.1  testican-2 isoform X1

    Conserved Domains (4) summary
    cd00191
    Location:261325
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd00252
    Location:195226
    EFh_SPARC_EC; EF-hand motif [structural motif]
    cl25349
    Location:149259
    EFh_SPARC_EC; EF-hand, extracellular calcium-binding (EC) motif, found in secreted protein acidic and rich in cysteine (SPARC)-like proteins
    pfam07648
    Location:84130
    Kazal_2; Kazal-type serine protease inhibitor domain
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