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Spock2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2 [ Mus musculus (house mouse) ]

Gene ID: 94214, updated on 17-Aug-2024

Summary

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Official Symbol
Spock2provided by MGI
Official Full Name
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2provided by MGI
Primary source
MGI:MGI:1891351
See related
Ensembl:ENSMUSG00000058297 AllianceGenome:MGI:1891351
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gcap26; mKIAA0275
Summary
Enables extracellular matrix binding activity and glycosaminoglycan binding activity. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan; and positive regulation of cell-substrate adhesion. Located in collagen-containing extracellular matrix. Is expressed in Sertoli cell and germ cell of testis. Orthologous to human SPOCK2 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 116.0), cortex adult (RPKM 84.9) and 12 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 B4; 10 29.69 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (59942079..59971020)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (60106257..60135198)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26792 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:59432972-59433155 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:59436913-59437130 Neighboring gene DNA-damage-inducible transcript 4 Neighboring gene STARR-positive B cell enhancer mm9_chr10:59460432-59460732 Neighboring gene anaphase promoting complex subunit 16 Neighboring gene activating signal cointegrator 1 complex subunit 1 Neighboring gene STARR-positive B cell enhancer ABC_E2937 Neighboring gene predicted gene, 51801 Neighboring gene microRNA 6906 Neighboring gene STARR-positive B cell enhancer ABC_E5138 Neighboring gene STARR-seq mESC enhancer starr_26799 Neighboring gene predicted gene, 51802 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:59631170-59631353 Neighboring gene STARR-positive B cell enhancer ABC_E10611 Neighboring gene STARR-positive B cell enhancer mm9_chr10:59652431-59652731 Neighboring gene STARR-positive B cell enhancer ABC_E11440 Neighboring gene carbohydrate sulfotransferase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Overexpression of Spock2 in mice leads to altered lung alveolar development and worsens lesions induced by hyperoxia. Hadchouel A, et al. Am J Physiol Lung Cell Mol Physiol, 2020 Jul 1. PMID 32374670
  2. Mouse testican-2. Expression, glycosylation, and effects on neurite outgrowth. Schnepp A, et al. J Biol Chem, 2005 Mar 25. PMID 15657052
  3. Molecular cloning of testican-2: defining a novel calcium-binding proteoglycan family expressed in brain. Vannahme C, et al. J Neurochem, 1999 Jul. PMID 10386950
  4. Structural abnormalities of corpus callosum and cortical axonal tracts accompanied by decreased anxiety-like behavior and lowered sociability in spock3- mutant mice. Yamamoto A, et al. Dev Neurosci, 2014. PMID 25138526
  5. Cross-platform single cell analysis of kidney development shows stromal cells express Gdnf. Magella B, et al. Dev Biol, 2018 Feb 1. PMID 29183737, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables extracellular matrix binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables extracellular matrix structural constituent conferring compression resistance RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
enables glycosaminoglycan binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within extracellular matrix organization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cell-substrate adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
testican-2
Names
granule cell antiserum positive 26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052994.2 → NP_443720.1  testican-2 precursor

    See identical proteins and their annotated locations for NP_443720.1

    Status: PROVISIONAL

    Source sequence(s)
    BC057324
    Consensus CDS
    CCDS35910.1
    UniProtKB/Swiss-Prot
    Q9ER58
    UniProtKB/TrEMBL
    F6SLR4
    Related
    ENSMUSP00000113115.3, ENSMUST00000121820.9
    Conserved Domains (4) summary
    smart00280
    Location:147 → 180
    KAZAL; Kazal type serine protease inhibitors
    cd00191
    Location:311 → 375
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd00252
    Location:198 → 315
    SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
    pfam10591
    Location:197 → 302
    SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    59942079..59971020
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514347.5 → XP_006514410.1  testican-2 isoform X1

    UniProtKB/TrEMBL
    Q80U51
    Conserved Domains (4) summary
    cd00191
    Location:261 → 325
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd00252
    Location:195 → 226
    EFh_SPARC_EC; EF-hand motif [structural motif]
    cl25349
    Location:149 → 259
    EFh_SPARC_EC; EF-hand, extracellular calcium-binding (EC) motif, found in secreted protein acidic and rich in cysteine (SPARC)-like proteins
    pfam07648
    Location:84 → 130
    Kazal_2; Kazal-type serine protease inhibitor domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ER58.1 GenPept UniProtKB/Swiss-Prot:Q9ER58

Gene LinkOut

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