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SPOCK2 SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2 [ Homo sapiens (human) ]

Gene ID: 9806, updated on 1-Aug-2020

Summary

Official Symbol
SPOCK2provided by HGNC
Official Full Name
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2provided by HGNC
Primary source
HGNC:HGNC:13564
See related
Ensembl:ENSG00000107742 MIM:607988
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
testican-2
Summary
This gene encodes a protein which binds with glycosaminoglycans to form part of the extracellular matrix. The protein contains thyroglobulin type-1, follistatin-like, and calcium-binding domains, and has glycosaminoglycan attachment sites in the acidic C-terminal region. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Expression
Biased expression in lung (RPKM 58.9), brain (RPKM 55.4) and 13 other tissues See more
Orthologs

Genomic context

See SPOCK2 in Genome Data Viewer
Location:
10q22.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (72059034..72095313, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (73818792..73848790, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene NFE2L2 motif-containing MPRA enhancers 43 and 138 Neighboring gene carbohydrate sulfotransferase 3 Neighboring gene activating signal cointegrator 1 complex subunit 1 Neighboring gene ribosomal protein L15 pseudogene 14 Neighboring gene anaphase promoting complex subunit 16

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3.
NHGRI GWA Catalog
Genome-wide meta-analyses of smoking behaviors in African Americans.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ97039

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
extracellular matrix binding IEA
Inferred from Electronic Annotation
more info
 
glycosaminoglycan binding IEA
Inferred from Electronic Annotation
more info
 
metalloendopeptidase inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix organization NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of endopeptidase activity TAS
Traceable Author Statement
more info
PubMed 
peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell motility TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cell-substrate adhesion IEA
Inferred from Electronic Annotation
more info
 
regulation of cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
synapse assembly NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular matrix NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
testican-2
Names
SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2
SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134434.1NP_001127906.1  testican-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001127906.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) shares only the two most-5' exons with variant 2 and has a distinct exon at its 3' end. This results in a protein (isoform 1) with a severely truncated C-terminus that lacks a SPARC_EC domain when compared to isoform 2.
    Source sequence(s)
    AA922448, AK307091, AW026489, DA150747, DC305070
    Consensus CDS
    CCDS44431.1
    UniProtKB/Swiss-Prot
    Q92563
    Related
    ENSP00000397715.1, ENST00000412663.5
  2. NM_001244950.2NP_001231879.1  testican-2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001231879.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has a different 5' UTR, compared to variant 2. Variants 2 and 3 encode the same protein (isoform 2).
    Source sequence(s)
    AC022392, BC023558, BQ029472
    Consensus CDS
    CCDS7313.1
    UniProtKB/Swiss-Prot
    Q92563
    Related
    ENSP00000362201.2, ENST00000373109.7
    Conserved Domains (4) summary
    smart00280
    Location:147180
    KAZAL; Kazal type serine protease inhibitors
    cd00191
    Location:312376
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd00252
    Location:198316
    SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
    pfam10591
    Location:197303
    SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region
  3. NM_014767.2NP_055582.1  testican-2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_055582.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer protein (isoform 2). Variants 2 and 3 encode the same protein.
    Source sequence(s)
    AC022392, AY358921, BP252465, BQ002304, D87465, DA150747, DC305070
    Consensus CDS
    CCDS7313.1
    UniProtKB/Swiss-Prot
    Q92563
    Related
    ENSP00000321108.4, ENST00000317376.8
    Conserved Domains (4) summary
    smart00280
    Location:147180
    KAZAL; Kazal type serine protease inhibitors
    cd00191
    Location:312376
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd00252
    Location:198316
    SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
    pfam10591
    Location:197303
    SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    72059034..72095313 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540404.3XP_011538706.1  testican-2 isoform X1

    See identical proteins and their annotated locations for XP_011538706.1

    UniProtKB/TrEMBL
    A0A024QZQ5
    Related
    ENSP00000439445.2, ENST00000536168.2
    Conserved Domains (4) summary
    smart00280
    Location:144177
    KAZAL; Kazal type serine protease inhibitors
    cd00191
    Location:309373
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd00252
    Location:195313
    SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
    pfam10591
    Location:194300
    SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region
  2. XM_017016985.2XP_016872474.1  testican-2 isoform X2

    UniProtKB/Swiss-Prot
    Q92563
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