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Hrg histidine-rich glycoprotein [ Mus musculus (house mouse) ]

Gene ID: 94175, updated on 14-May-2024

Summary

Official Symbol
Hrgprovided by MGI
Official Full Name
histidine-rich glycoproteinprovided by MGI
Primary source
MGI:MGI:2146636
See related
Ensembl:ENSMUSG00000022877 AllianceGenome:MGI:2146636
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hprg; Hrgp; D16jh2; D18020
Summary
Enables serine-type endopeptidase inhibitor activity. Involved in several processes, including negative regulation of blood vessel endothelial cell migration; positive regulation of blood vessel remodeling; and positive regulation of immune response to tumor cell. Acts upstream of or within several processes, including heme export; negative regulation of fibrinolysis; and regulation of transcription from RNA polymerase II promoter in response to iron. Located in endolysosome and phagolysosome membrane. Human ortholog(s) of this gene implicated in thrombophilia due to HRG deficiency and thrombosis. Orthologous to human HRG (histidine rich glycoprotein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward liver adult (RPKM 112.7) See more
Orthologs
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Genomic context

See Hrg in Genome Data Viewer
Location:
16 B1; 16 13.79 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (22769822..22780409)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (22951072..22961659)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30611 Neighboring gene fetuin beta Neighboring gene STARR-seq mESC enhancer starr_40421 Neighboring gene STARR-seq mESC enhancer starr_40422 Neighboring gene kininogen 2 Neighboring gene STARR-seq mESC enhancer starr_40423 Neighboring gene STARR-seq mESC enhancer starr_40424 Neighboring gene transportin 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40425 Neighboring gene tryptophan rich basic protein pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables heme binding ISO
Inferred from Sequence Orthology
more info
 
enables heparan sulfate proteoglycan binding ISO
Inferred from Sequence Orthology
more info
 
enables heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables heparin binding ISO
Inferred from Sequence Orthology
more info
 
enables immunoglobulin binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables serine-type endopeptidase inhibitor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within blood coagulation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in cytolysis by host of symbiont cells ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to fungus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to fungus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of fibrinolysis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hemostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of blood vessel endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of endothelial cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of fibrinolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of fibrinolysis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular endothelial growth factor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in platelet activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood vessel remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of blood vessel remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of immune response to tumor cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of immune response to tumor cell ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of blood coagulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of blood coagulation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of platelet activation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of platelet activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in collagen-containing extracellular matrix HDA PubMed 
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
histidine-rich glycoprotein
Names
histidine-proline-rich glycoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053176.2NP_444406.2  histidine-rich glycoprotein precursor

    See identical proteins and their annotated locations for NP_444406.2

    Status: VALIDATED

    Source sequence(s)
    AI182388, AI196096, AI303163, CB593922, CB946752
    Consensus CDS
    CCDS49800.1
    UniProtKB/Swiss-Prot
    Q6YK32, Q6YKA2, Q99PS5, Q99PS6, Q9ESB3
    UniProtKB/TrEMBL
    A0A0R4J039
    Related
    ENSMUSP00000023590.9, ENSMUST00000023590.9
    Conserved Domains (1) summary
    cl09238
    Location:30131
    CY; Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    22769822..22780409
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)