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HRG histidine rich glycoprotein [ Homo sapiens (human) ]

Gene ID: 3273, updated on 7-Jun-2020

Summary

Official Symbol
HRGprovided by HGNC
Official Full Name
histidine rich glycoproteinprovided by HGNC
Primary source
HGNC:HGNC:5181
See related
Ensembl:ENSG00000113905 MIM:142640
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HPRG; HRGP; THPH11
Summary
This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. The encoded protein also has a peptide that displays antimicrobial activity against C. albicans, E. coli, S. aureus, P. aeruginosa, and E. faecalis. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels. [provided by RefSeq, Nov 2014]
Expression
Restricted expression toward liver (RPKM 1677.7) See more
Orthologs

Genomic context

See HRG in Genome Data Viewer
Location:
3q27.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (186665975..186678235)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (186383747..186396023)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene alpha 2-HS glycoprotein Neighboring gene uncharacterized LOC105374258 Neighboring gene fetuin B Neighboring gene histidine rich glycoprotein pseudogene Neighboring gene kininogen 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Thrombophilia, histidine-rich glycoprotein-related
MedGen: C2751090 OMIM: 613116 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Common variants of large effect in F12, KNG1, and HRG are associated with activated partial thromboplastin time.
NHGRI GWA Catalog
Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp779H1622

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cysteine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heme binding IDA
Inferred from Direct Assay
more info
PubMed 
heparan sulfate proteoglycan binding IDA
Inferred from Direct Assay
more info
PubMed 
heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
immunoglobulin binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signaling receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
antimicrobial humoral immune response mediated by antimicrobial peptide IDA
Inferred from Direct Assay
more info
PubMed 
chemotaxis IEA
Inferred from Electronic Annotation
more info
 
cytolysis by host of symbiont cells IDA
Inferred from Direct Assay
more info
PubMed 
defense response to fungus IDA
Inferred from Direct Assay
more info
PubMed 
fibrinolysis TAS
Traceable Author Statement
more info
 
heme transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of blood vessel endothelial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell adhesion mediated by integrin IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of endothelial cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of fibrinolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of lamellipodium assembly IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of vascular endothelial growth factor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
platelet activation IDA
Inferred from Direct Assay
more info
PubMed 
platelet degranulation TAS
Traceable Author Statement
more info
 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of blood vessel remodeling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of focal adhesion assembly IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of immune response to tumor cell IDA
Inferred from Direct Assay
more info
PubMed 
regulation of actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of blood coagulation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of platelet activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of platelet activation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of protein complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
blood microparticle HDA PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
collagen-containing extracellular matrix HDA PubMed 
endolysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular region HDA PubMed 
extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
platelet alpha granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
histidine-rich glycoprotein
Names
histidine-proline-rich glycoprotein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021485.2 RefSeqGene

    Range
    10737..23025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_601

mRNA and Protein(s)

  1. NM_000412.5NP_000403.1  histidine-rich glycoprotein precursor

    See identical proteins and their annotated locations for NP_000403.1

    Status: REVIEWED

    Source sequence(s)
    AI800281, BC150591
    Consensus CDS
    CCDS3280.1
    UniProtKB/Swiss-Prot
    P04196
    Related
    ENSP00000232003.4, ENST00000232003.5
    Conserved Domains (1) summary
    smart00043
    Location:21127
    CY; Cystatin-like domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    186665975..186678235
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247415.4XP_005247472.1  histidine-rich glycoprotein isoform X1

    Conserved Domains (1) summary
    smart00043
    Location:21127
    CY; Cystatin-like domain
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