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MED21 mediator complex subunit 21 [ Homo sapiens (human) ]

Gene ID: 9412, updated on 1-Aug-2020

Summary

Official Symbol
MED21provided by HGNC
Official Full Name
mediator complex subunit 21provided by HGNC
Primary source
HGNC:HGNC:11473
See related
Ensembl:ENSG00000152944 MIM:603800
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SRB7; SURB7; hSrb7
Summary
This gene encodes a member of the mediator complex subunit 21 family. The encoded protein interacts with the human RNA polymerase II holoenzyme and is involved in transcriptional regulation of RNA polymerase II transcribed genes. A pseudogene of this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Expression
Ubiquitous expression in adrenal (RPKM 13.1), testis (RPKM 11.0) and 25 other tissues See more
Orthologs

Genomic context

See MED21 in Genome Data Viewer
Location:
12p11.23
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (27022522..27030673)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (27175455..27183606)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene integrator complex subunit 13 Neighboring gene FGFR1 oncogene partner 2 Neighboring gene transmembrane 7 superfamily member 3 Neighboring gene nontranscribed chromatin-defined enhancer upstream of C12orf71 Neighboring gene chromosome 12 open reading frame 71

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of mediator complex subunit 21 (MED21) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat interacts with the RNA polymerase II holoenzyme, which includes SRB7, during Tat-mediated transactivation of the HIV-1 LTR PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-directed 5'-3' RNA polymerase activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
RNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
blastocyst development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mediator complex IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mediator of RNA polymerase II transcription subunit 21
Names
RNA polymerase II holoenzyme component SRB7
RNAPII complex component SRB7
SRB7 suppressor of RNA polymerase B homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271811.1NP_001258740.1  mediator of RNA polymerase II transcription subunit 21 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC092747, DB024509, HY075642
    Conserved Domains (1) summary
    pfam11221
    Location:156
    Med21; Subunit 21 of Mediator complex
  2. NM_004264.5NP_004255.2  mediator of RNA polymerase II transcription subunit 21 isoform 1

    See identical proteins and their annotated locations for NP_004255.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC092747
    Consensus CDS
    CCDS8711.1
    UniProtKB/Swiss-Prot
    Q13503
    UniProtKB/TrEMBL
    A0A024RAW0
    Related
    ENSP00000282892.3, ENST00000282892.4
    Conserved Domains (1) summary
    pfam11221
    Location:1127
    Med21; Subunit 21 of Mediator complex

RNA

  1. NR_073463.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC092747, AK309064, DB024509
  2. NR_073464.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC092747, DA420057, DB024509

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    27022522..27030673
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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