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TMPRSS11D transmembrane serine protease 11D [ Homo sapiens (human) ]

Gene ID: 9407, updated on 23-Nov-2021

Summary

Official Symbol
TMPRSS11Dprovided by HGNC
Official Full Name
transmembrane serine protease 11Dprovided by HGNC
Primary source
HGNC:HGNC:24059
See related
Ensembl:ENSG00000153802 MIM:605369
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ASP; HAT
Summary
This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. This protein facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. [provided by RefSeq, Aug 2021]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in SARS-CoV-2 infection.
Expression
Restricted expression toward esophagus (RPKM 30.2) See more
Orthologs
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Genomic context

See TMPRSS11D in Genome Data Viewer
Location:
4q13.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (67820876..67885063, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (68686594..68749720, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene transmembrane serine protease 11C, pseudogene Neighboring gene uncharacterized LOC102724780 Neighboring gene transmembrane serine protease 11A Neighboring gene transmembrane serine protease 11G, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC150587, MGC150588

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables peptidase activity TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in respiratory gaseous exchange by respiratory system TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
transmembrane protease serine 11D
Names
adrenal secretory serine protease
airway trypsin-like protease
transmembrane protease, serine 11D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004262.3NP_004253.1  transmembrane protease serine 11D

    See identical proteins and their annotated locations for NP_004253.1

    Status: REVIEWED

    Source sequence(s)
    AB002134, AC096653, AK094054, AL603214, BC033295
    Consensus CDS
    CCDS3518.1
    UniProtKB/Swiss-Prot
    O60235
    Related
    ENSP00000283916.6, ENST00000283916.11
    Conserved Domains (3) summary
    smart00020
    Location:186412
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:187415
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam01390
    Location:48143
    SEA; SEA domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    67820876..67885063 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005265710.4XP_005265767.1  transmembrane protease serine 11D isoform X1

    See identical proteins and their annotated locations for XP_005265767.1

    UniProtKB/TrEMBL
    B4DL57
    Conserved Domains (2) summary
    smart00020
    Location:69295
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:70298
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. XM_017008851.1XP_016864340.1  transmembrane protease serine 11D isoform X2

    Related
    ENST00000505533.1
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