Format

Send to:

Choose Destination

SELENOF selenoprotein F [ Homo sapiens (human) ]

Gene ID: 9403, updated on 5-Dec-2021

Summary

Official Symbol
SELENOFprovided by HGNC
Official Full Name
selenoprotein Fprovided by HGNC
Primary source
HGNC:HGNC:17705
See related
Ensembl:ENSG00000183291 MIM:606254
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SEP15
Summary
The protein encoded by this gene belongs to the SEP15/selenoprotein M family. The exact function of this protein is not known; however, it has been found to associate with UDP-glucose:glycoprotein glucosyltransferase (UGTR), an endoplasmic reticulum(ER)-resident protein, which is involved in the quality control of protein folding. The association with UGTR retains this protein in the ER, where it may play a role in protein folding. It has also been suggested to have a role in cancer etiology. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2016]
Expression
Ubiquitous expression in thyroid (RPKM 119.6), urinary bladder (RPKM 69.9) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See SELENOF in Genome Data Viewer
Location:
1p22.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (86862445..86914577, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (87328128..87380260, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L17 pseudogene 5 Neighboring gene uncharacterized LOC105378831 Neighboring gene heparan sulfate 2-O-sulfotransferase 1 Neighboring gene ubiquitin like modifier activating enzyme 2 pseudogene Neighboring gene ubiquitin like modifier activating enzyme 2 pseudogene Neighboring gene long intergenic non-protein coding RNA 1140

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables selenium binding IEA
Inferred from Electronic Annotation
more info
 
enables thioredoxin peroxidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in 'de novo' posttranslational protein folding TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
involved_in sperm DNA condensation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum lumen IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
selenoprotein F
Names
15 kDa selenoprotein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004261.5NP_004252.2  selenoprotein F isoform 1 precursor

    See identical proteins and their annotated locations for NP_004252.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK225640, BC016359, BU941543
    Consensus CDS
    CCDS76178.1
    UniProtKB/Swiss-Prot
    O60613
    Related
    ENSP00000328729.6, ENST00000331835.10
    Conserved Domains (1) summary
    pfam08806
    Location:88163
    Sep15_SelM; Sep15/SelM redox domain
  2. NM_203341.3NP_976086.1  selenoprotein F isoform 2 precursor

    See identical proteins and their annotated locations for NP_976086.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK225640, BC016359, BC021697
    Consensus CDS
    CCDS76177.1
    UniProtKB/Swiss-Prot
    O60613
    Related
    ENSP00000359585.2, ENST00000370554.5
    Conserved Domains (1) summary
    pfam08806
    Location:88105
    Sep15_SelM; Sep15/SelM redox domain

RNA

  1. NR_144512.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate 5' terminal exon compared to variant 1. It is represented as non-coding because it lacks an in-frame ORF.
    Source sequence(s)
    AK225640, BC016359, DB452758
  2. NR_144513.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an alternate 5' terminal exon compared to variant 1. It is represented as non-coding because it lacks an in-frame ORF.
    Source sequence(s)
    AK225640, BC016359, HY018581

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    86862445..86914577 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center