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Selenof selenoprotein F [ Mus musculus (house mouse) ]

Gene ID: 93684, updated on 26-Sep-2022


Official Symbol
Selenofprovided by MGI
Official Full Name
selenoprotein Fprovided by MGI
Primary source
See related
Ensembl:ENSMUSG00000037072 AllianceGenome:MGI:1927947
Gene type
protein coding
RefSeq status
Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sep15; 9430015P09Rik
The protein encoded by this gene belongs to the SEP15/selenoprotein M family. The exact function of this protein is not known; however, it has been found to associate with UDP-glucose:glycoprotein glucosyltransferase (UGTR), an endoplasmic reticulum(ER)-resident protein, which is involved in the quality control of protein folding. The association with UGTR retains this protein in the ER, where it may play a role in protein folding. Knockout studies in mice also suggest a role for this gene in cataract formation and colon carcinogenesis. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Nov 2016]
Ubiquitous expression in placenta adult (RPKM 136.8), bladder adult (RPKM 131.5) and 28 other tissues See more
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Genomic context

See Selenof in Genome Data Viewer
3; 3 H2
Exon count:
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (144276188..144303438)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (144570427..144597677)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene heparan sulfate 2-O-sulfotransferase 1 Neighboring gene predicted gene 43560 Neighboring gene predicted gene, 46829 Neighboring gene ribosomal protein L9, pseudogene 8 Neighboring gene SH3-domain GRB2-like B1 (endophilin)

Genomic regions, transcripts, and products


  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a


GeneRIFs: Gene References Into Functions

What's a GeneRIF?



Alleles of this type are documented at Mouse Genome Informatics  (MGI)


Products Interactant Other Gene Complex Source Pubs Description

General gene information


Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
enables protein binding IPI
Inferred from Physical Interaction
more info
enables selenium binding ISO
Inferred from Sequence Orthology
more info
enables thioredoxin peroxidase activity ISO
Inferred from Sequence Orthology
more info
Process Evidence Code Pubs
involved_in 'de novo' post-translational protein folding TAS
Traceable Author Statement
more info
involved_in sperm DNA condensation ISO
Inferred from Sequence Orthology
more info
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
is_active_in endoplasmic reticulum lumen IBA
Inferred from Biological aspect of Ancestor
more info
located_in endoplasmic reticulum lumen ISO
Inferred from Sequence Orthology
more info
located_in endoplasmic reticulum lumen ISS
Inferred from Sequence or Structural Similarity
more info

General protein information

Preferred Names
selenoprotein F
15 kDa selenoprotein
selenoprotein 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053102.2NP_444332.1  selenoprotein F precursor

    See identical proteins and their annotated locations for NP_444332.1

    Status: REVIEWED

    Source sequence(s)
    AC123880, AF288740, AK159085, BY262067, CJ134973
    Consensus CDS
    ENSMUSP00000046910.7, ENSMUST00000082437.11
    Conserved Domains (1) summary
    Sep15_SelM; Sep15/SelM redox domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J


  1. NC_000069.7 Reference GRCm39 C57BL/6J

    GenBank, FASTA, Sequence Viewer (Graphics)