U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Selenof selenoprotein F [ Mus musculus (house mouse) ]

Gene ID: 93684, updated on 18-Apr-2024

Summary

Official Symbol
Selenofprovided by MGI
Official Full Name
selenoprotein Fprovided by MGI
Primary source
MGI:MGI:1927947
See related
Ensembl:ENSMUSG00000037072 AllianceGenome:MGI:1927947
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sep15; 9430015P09Rik
Summary
The protein encoded by this gene belongs to the SEP15/selenoprotein M family. The exact function of this protein is not known; however, it has been found to associate with UDP-glucose:glycoprotein glucosyltransferase (UGTR), an endoplasmic reticulum(ER)-resident protein, which is involved in the quality control of protein folding. The association with UGTR retains this protein in the ER, where it may play a role in protein folding. Knockout studies in mice also suggest a role for this gene in cataract formation and colon carcinogenesis. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Nov 2016]
Expression
Ubiquitous expression in placenta adult (RPKM 136.8), bladder adult (RPKM 131.5) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
3 H2; 3 68.94 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (144276188..144303438)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (144570427..144597677)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene heparan sulfate 2-O-sulfotransferase 1 Neighboring gene STARR-positive B cell enhancer mm9_chr3:144193966-144194266 Neighboring gene STARR-seq mESC enhancer starr_09180 Neighboring gene predicted gene 43560 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:144211269-144211545 Neighboring gene STARR-seq mESC enhancer starr_09181 Neighboring gene predicted gene, 46829 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:144233322-144233673 Neighboring gene STARR-seq mESC enhancer starr_09182 Neighboring gene ribosomal protein L9, pseudogene 8 Neighboring gene STARR-seq mESC enhancer starr_09183 Neighboring gene STARR-positive B cell enhancer ABC_E7949 Neighboring gene SH3-domain GRB2-like B1 (endophilin) Neighboring gene STARR-positive B cell enhancer mm9_chr3:144367228-144367528 Neighboring gene STARR-positive B cell enhancer ABC_E2099

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables selenium binding ISO
Inferred from Sequence Orthology
more info
 
enables thioredoxin peroxidase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in 'de novo' post-translational protein folding TAS
Traceable Author Statement
more info
PubMed 
involved_in sperm DNA condensation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum lumen IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum lumen ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum lumen ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
selenoprotein F
Names
15 kDa selenoprotein
selenoprotein 15

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053102.2NP_444332.1  selenoprotein F precursor

    See identical proteins and their annotated locations for NP_444332.1

    Status: REVIEWED

    Source sequence(s)
    AC123880, AF288740, AK159085, BY262067, CJ134973
    Consensus CDS
    CCDS17884.1
    UniProtKB/Swiss-Prot
    Q3TXW1, Q544W8, Q8VE40, Q9ERR7
    UniProtKB/TrEMBL
    A0A0R4J0K1
    Related
    ENSMUSP00000046910.7, ENSMUST00000082437.11
    Conserved Domains (1) summary
    pfam08806
    Location:85160
    Sep15_SelM; Sep15/SelM redox domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    144276188..144303438
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)