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ACTR8 actin related protein 8 [ Homo sapiens (human) ]

Gene ID: 93973, updated on 9-Sep-2025
Official Symbol
ACTR8provided by HGNC
Official Full Name
actin related protein 8provided by HGNC
Primary source
HGNC:HGNC:14672
See related
Ensembl:ENSG00000113812 MIM:619716; AllianceGenome:HGNC:14672
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARP8; hArp8; INO80N
Summary
Predicted to enable ATP binding activity. Involved in several processes, including chromatin remodeling; regulation of chromosome organization; and regulation of nucleobase-containing compound metabolic process. Located in centrosome and nucleoplasm. Part of Ino80 complex. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in testis (RPKM 6.6), kidney (RPKM 6.1) and 25 other tissues See more
Orthologs
mouse all
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See ACTR8 in Genome Data Viewer
Location:
3p21.1
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (53858992..53882152, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (53892233..53915392, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (53901093..53916179, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene calcium voltage-gated channel subunit alpha1 D Neighboring gene uncharacterized LOC124906242 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:53750142-53751341 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:53752305-53752885 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:53752886-53753466 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:53765682-53766222 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:53766223-53766761 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19969 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:53787515-53788014 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19972 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:53798133-53798649 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:53802933-53803434 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19973 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:53838519-53839320 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14466 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:53840931-53841432 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:53841433-53841932 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:53857324-53857923 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:53878721-53879561 Neighboring gene Sharpr-MPRA regulatory region 239 Neighboring gene choline dehydrogenase Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14468 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19974 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14469 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:53925074-53925974 Neighboring gene interleukin 17 receptor B Neighboring gene selenoprotein K Neighboring gene NANOG hESC enhancer GRCh37_chr3:54014583-54015161 Neighboring gene uncharacterized LOC105377095

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. The mammalian INO80 complex is recruited to DNA damage sites in an ARP8 dependent manner. Kashiwaba S, et al. Biochem Biophys Res Commun, 2010 Nov 26. PMID 20971067
  2. DNA binding properties of the actin-related protein Arp8 and its role in DNA repair. Osakabe A, et al. PLoS One, 2014. PMID 25299602, Free PMC Article
  3. The actin-related protein hArp8 accumulates on the mitotic chromosomes and functions in chromosome alignment. Aoyama N, et al. Exp Cell Res, 2008 Feb 15. PMID 18163988
  4. Distinct roles of ATM and ATR in the regulation of ARP8 phosphorylation to prevent chromosome translocations. Sun J, et al. Elife, 2018 May 8. PMID 29759113, Free PMC Article
  5. Yin Yang 1 extends the Myc-related transcription factors network in embryonic stem cells. Vella P, et al. Nucleic Acids Res, 2012 Apr. PMID 22210892, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Plays a regulatory role in the binding of Arp8 to DNA.
    Title: DNA binding properties of the actin-related protein Arp8 and its role in DNA repair.
  2. Binding studies reveal that Arp8 and the Arp8-Arp4-actin-HSA sub-complex of INO80 strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting that Arp8 functions as a nucleosome recognition module.
    Title: Structure of Actin-related protein 8 and its contribution to nucleosome binding.
  3. These results suggest that ARP8 is required for the recruitment of the mammalian INO80 complex to the laser-induced DNA damage sites.
    Title: The mammalian INO80 complex is recruited to DNA damage sites in an ARP8 dependent manner.
  4. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
  5. Expression of truncated hArp8 proteins and depletion of endogenous hArp8 by RNA interference caused misalignment of mitotic chromosomes, suggesting that chromosome-associated hArp8 has a role in chromosome behavior.
    Title: The actin-related protein hArp8 accumulates on the mitotic chromosomes and functions in chromosome alignment.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ12934, FLJ22579

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of macromolecule metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of nucleobase-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of telomere maintenance in response to DNA damage IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of telomere maintenance in response to DNA damage ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA strand elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of chromosome organization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of chromosome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of embryonic development IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in telomere maintenance IEA
Inferred from Electronic Annotation
more info
  
involved_in telomere maintenance ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Ino80 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ino80 complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
actin-related protein 8
Names
ARP8 actin related protein 8 homolog
INO80 complex subunit N

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410774.1 → NP_001397703.1  actin-related protein 8 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC012467
    Consensus CDS
    CCDS93290.1
    Related
    ENSP00000419429.1, ENST00000482349.5

  2. NM_022899.5 → NP_075050.3  actin-related protein 8 isoform 1

    See identical proteins and their annotated locations for NP_075050.3

    Status: VALIDATED

    Source sequence(s)
    AC012467, AK022996
    Consensus CDS
    CCDS2875.1
    UniProtKB/Swiss-Prot
    B3KSW7, Q8N566, Q9H663, Q9H981
    Related
    ENSP00000336842.3, ENST00000335754.8
    Conserved Domains (1) summary
    cl17037
    Location:162 → 619
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    53858992..53882152 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005265587.6 → XP_005265644.1  actin-related protein 8 isoform X1

    See identical proteins and their annotated locations for XP_005265644.1

    UniProtKB/Swiss-Prot
    B3KSW7, Q8N566, Q9H663, Q9H981
    Related
    ENSP00000633915.1, ENST00000963856.1
    Conserved Domains (1) summary
    cl17037
    Location:162 → 619
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  2. XM_047449238.1 → XP_047305194.1  actin-related protein 8 isoform X2

    UniProtKB/TrEMBL
    H0Y849

  3. XM_047449239.1 → XP_047305195.1  actin-related protein 8 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    53892233..53915392 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348447.1 → XP_054204422.1  actin-related protein 8 isoform X1

    UniProtKB/Swiss-Prot
    B3KSW7, Q8N566, Q9H663, Q9H981

  2. XM_054348448.1 → XP_054204423.1  actin-related protein 8 isoform X2

    UniProtKB/TrEMBL
    H0Y849

  3. XM_054348449.1 → XP_054204424.1  actin-related protein 8 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H981.2 GenPept UniProtKB/Swiss-Prot:Q9H981

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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