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ACTR8 actin related protein 8 [ Homo sapiens (human) ]

Gene ID: 93973, updated on 1-Jun-2020

Summary

Official Symbol
ACTR8provided by HGNC
Official Full Name
actin related protein 8provided by HGNC
Primary source
HGNC:HGNC:14672
See related
Ensembl:ENSG00000113812
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARP8; hArp8; INO80N
Expression
Ubiquitous expression in testis (RPKM 6.6), kidney (RPKM 6.1) and 25 other tissues See more
Orthologs

Genomic context

See ACTR8 in Genome Data Viewer
Location:
3p21.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (53858992..53882160, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (53898959..53916229, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 2578 Neighboring gene calcium voltage-gated channel subunit alpha1 D Neighboring gene choline dehydrogenase Neighboring gene interleukin 17 receptor B Neighboring gene selenoprotein K Neighboring gene uncharacterized LOC105377095

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12934, FLJ22579

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ATP-dependent chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA recombination IEA
Inferred from Electronic Annotation
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Ino80 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Ino80 complex IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
actin-related protein 8
Names
ARP8 actin related protein 8 homolog
INO80 complex subunit N

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022899.5NP_075050.3  actin-related protein 8

    See identical proteins and their annotated locations for NP_075050.3

    Status: VALIDATED

    Source sequence(s)
    AC012467, AK022996
    Consensus CDS
    CCDS2875.1
    UniProtKB/Swiss-Prot
    Q9H981
    Related
    ENSP00000336842.3, ENST00000335754.8
    Conserved Domains (1) summary
    cl25542
    Location:162619
    Actin; Actin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    53858992..53882160 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534249.3XP_011532551.1  actin-related protein 8 isoform X2

    See identical proteins and their annotated locations for XP_011532551.1

    UniProtKB/Swiss-Prot
    Q9H981
    Related
    ENSP00000419429.1, ENST00000482349.5
    Conserved Domains (1) summary
    cl25542
    Location:51508
    Actin; Actin
  2. XM_005265587.5XP_005265644.1  actin-related protein 8 isoform X1

    See identical proteins and their annotated locations for XP_005265644.1

    UniProtKB/Swiss-Prot
    Q9H981
    Conserved Domains (1) summary
    cl25542
    Location:162619
    Actin; Actin

RNA

  1. XR_940516.3 RNA Sequence

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