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ACTR8 actin related protein 8 [ Homo sapiens (human) ]

Gene ID: 93973, updated on 26-Oct-2022

Summary

Official Symbol
ACTR8provided by HGNC
Official Full Name
actin related protein 8provided by HGNC
Primary source
HGNC:HGNC:14672
See related
Ensembl:ENSG00000113812 MIM:619716; AllianceGenome:HGNC:14672
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARP8; hArp8; INO80N
Summary
Predicted to enable ATP binding activity. Predicted to be involved in chromatin remodeling; double-strand break repair; and regulation of transcription, DNA-templated. Located in centrosome and nucleoplasm. Part of Ino80 complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 6.6), kidney (RPKM 6.1) and 25 other tissues See more
Orthologs
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Genomic context

See ACTR8 in Genome Data Viewer
Location:
3p21.1
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (53858992..53882152, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (53900306..53915392, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (53901093..53916179, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene calcium voltage-gated channel subunit alpha1 D Neighboring gene uncharacterized LOC124906242 Neighboring gene Sharpr-MPRA regulatory region 239 Neighboring gene choline dehydrogenase Neighboring gene interleukin 17 receptor B Neighboring gene selenoprotein K Neighboring gene uncharacterized LOC105377095

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12934, FLJ22579

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of Ino80 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Ino80 complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
actin-related protein 8
Names
ARP8 actin related protein 8 homolog
INO80 complex subunit N

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410774.1NP_001397703.1  actin-related protein 8 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC012467
    Consensus CDS
    CCDS93290.1
  2. NM_022899.5NP_075050.3  actin-related protein 8 isoform 1

    See identical proteins and their annotated locations for NP_075050.3

    Status: VALIDATED

    Source sequence(s)
    AC012467, AK022996
    Consensus CDS
    CCDS2875.1
    UniProtKB/Swiss-Prot
    Q9H663, Q9H981
    Related
    ENSP00000336842.3, ENST00000335754.8
    Conserved Domains (1) summary
    cl17037
    Location:162619
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    53858992..53882152 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005265587.6XP_005265644.1  actin-related protein 8 isoform X1

    See identical proteins and their annotated locations for XP_005265644.1

    UniProtKB/Swiss-Prot
    Q9H663, Q9H981
    Conserved Domains (1) summary
    cl17037
    Location:162619
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  2. XM_011534249.4XP_011532551.1  actin-related protein 8 isoform X2

    UniProtKB/Swiss-Prot
    Q9H981
    Related
    ENSP00000419429.1, ENST00000482349.5
    Conserved Domains (1) summary
    cl17037
    Location:51508
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  3. XM_047449238.1XP_047305194.1  actin-related protein 8 isoform X3

  4. XM_047449239.1XP_047305195.1  actin-related protein 8 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    53900306..53915392 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)